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> Protein (NX_P43694)
Protein (NX_P43694)
Protein
Gene SymbolGATA4 to neXtProt (NX_P43694)
DescriptionTranscription factor GATA-4
Chromosome8
Location8p23.1 (11534468 ~ 11617511) to Ensembl
Sequene Features : Isoforms 2, Variants 65, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cardiac muscle cell contraction
.seminiferous tubule development
.epithelial cell fate commitment
  + 48 more...
.co-SMAD binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 10 more...
.RNA polymerase II transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 65 1
2014-09-19protein level
2 51 1
2014-05-27protein level
1 51 1
2014-02-25protein level
1 50 1
2013-12-09protein level
1 43 1
2013-11-01protein level
1 43 1
2013-09-12protein level
1 43 1
2013-08-17protein level
1 43 1
2013-07-15protein level
1 38 1
2013-06-11protein level
1 38 1
2013-02-12protein level
1 28 2
2012-12-20protein level
1 30 2
2012-10-30protein level
1 33 2
2012-10-07protein level
1 33 2
2012-08-24protein level
1 33 2
2012-07-28protein level
1 33 2
2012-06-08protein level
1 40 2
2012-05-07protein level
1 24 2
2012-04-10protein level
1 24 2
2012-01-13protein level
1 24 1
2011-12-20protein level
1 24 1
2011-11-11protein level
1 24 1
2011-08-23protein level
1 24 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43694-1
1 13 2 44537.3789
NX_P43694-2
1 13 2 44636.447
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7049352,EBI-1255893 KLF13  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
.negative regulation of cell proliferation
.transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain7
connective tissue53
embryonic tissue42
eye14
heart33
intestine8
liver34
lung11
ovary108
pancreas60
placenta17
prostate5
skin4
stomach62
testis71
thymus12
Health State
TissuesTPM*
normal20
gastrointestinal tumor33
germ cell tumor15
glioma9
liver tumor62
ovarian tumor131
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor63
Developmental Stage
TissuesTPM*
adult18
embryoid body42
blastocyst97
fetus37
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1
duodenum57.8
gallbladder9.4
heart muscle67.7
liver13
ovary81.7
pancreas18.4
placenta15.2
small intestine25.8
stomach35.9
testis34
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#187500, phenotype) Tetralogy of fallot; TOFOMIM
2(*600576, gene) Gata-binding protein 4; GATA4OMIM
3(#607941, phenotype) Atrial septal defect 2; ASD2OMIM
4(#614429, phenotype) Ventricular septal defect 1; VSD1OMIM
5(#614430, phenotype) Atrioventricular septal defect 4; AVSD4OMIM


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