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> Protein (NX_P43699)
Protein (NX_P43699)
Protein
Gene SymbolNKX2-1 to neXtProt (NX_P43699)
DescriptionHomeobox protein Nkx-2.1
Chromosome14
Location14q13.3 (36985602 ~ 36990354) to Ensembl
Sequene Features : Isoforms 2, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Type II pneumocyte differentiation
.Clara cell differentiation
.epithelial tube branching involved in lung morphogenesis
  + 32 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.enzyme binding
  + 5 more...
.transcription factor complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 37 0
2014-09-19protein level
2 24 0
2014-05-27protein level
2 24 0
2014-02-25protein level
2 21 0
2013-12-09protein level
2 17 0
2013-11-01protein level
2 17 0
2013-09-12protein level
2 17 0
2013-08-17protein level
2 17 0
2013-07-15protein level
2 12 0
2013-06-11protein level
2 12 0
2013-02-12protein level
2 8 0
2012-12-20protein level
2 9 0
2012-10-30protein level
2 8 0
2012-10-07protein level
2 8 0
2012-08-24protein level
2 5 0
2012-07-28protein level
2 5 0
2012-06-08protein level
2 9 0
2012-05-07protein level
2 9 0
2012-04-10protein level
2 9 0
2012-01-13protein level
2 9 0
2011-12-20protein level
2 9 0
2011-11-11protein level
2 9 0
2011-08-23protein level
2 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P43699-1
0 8 3 38571.7695
NX_P43699-3
2 8 3 41710.3829
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1391923,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-1391923,EBI-1047110 CCDC59  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood65
brain1
connective tissue20
embryonic tissue9
lung80
pituitary gland121
prostate15
stomach10
thyroid107
uterus4
Health State
TissuesTPM*
normal8
chondrosarcoma36
gastrointestinal tumor8
head and neck tumor7
leukemia84
lung tumor29
non-neoplasia10
prostate cancer28
uterine tumor11
Developmental Stage
TissuesTPM*
adult8
fetus16
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
lung50.6
thyroid gland39.8
Tissues
TissuesExpression level
bronchusLow
lungMedium
nasopharynxLow
thyroid glandHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#118700, phenotype) Chorea, benign hereditary; BHCOMIM
2(*600635, gene) Nk2 homeobox 1; NKX2-1OMIM
3(#610978, phenotype) Choreoathetosis, hypothyroidism, and neonatal respiratory distressOMIM


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