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> Protein (NX_P45880)
Protein (NX_P45880)
Protein
Gene SymbolVDAC2 to neXtProt (NX_P45880)
DescriptionVoltage-dependent anion-selective channel protein 2
Chromosome10
Location10q22.2 (76969912 ~ 76991206) to Ensembl
Sequene Features : Isoforms 3, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway
.regulation of anion transmembrane transport
.negative regulation of protein polymerization
.anion transport
.porin activity
.voltage-gated anion channel activity
.nucleotide binding
.extracellular exosome
.pore complex
.membrane raft
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 32 8
2014-09-19protein level
3 26 8
2014-05-27protein level
3 25 8
2014-02-25protein level
3 26 7
2013-12-09protein level
3 20 7
2013-11-01protein level
3 20 5
2013-09-12protein level
3 20 4
2013-08-17protein level
3 20 4
2013-07-15protein level
3 13 3
2013-06-11protein level
3 13 3
2013-02-12protein level
3 7 10
2012-12-20protein level
3 8 10
2012-10-30protein level
3 9 10
2012-10-07protein level
3 9 11
2012-08-24protein level
3 9 11
2012-07-28protein level
3 9 11
2012-06-08protein level
3 9 11
2012-05-07protein level
3 6 11
2012-04-10protein level
3 6 11
2012-01-13protein level
3 4 11
2011-12-20protein level
3 4 11
2011-11-11protein level
3 4 9
2011-08-23protein level
3 4 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P45880-1
2 15 0 33350.4526
NX_P45880-2
1 15 0 30392.9496
NX_P45880-3
1 15 0 31546.4584
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-354022,EBI-6123466 FAM162A  
  .positive regulation of release of cytochrome c from mitochondria
.cellular response to hypoxia
.neuron apoptotic process
  + 3 more...
.N/A .extracellular exosome
.integral component of membrane
.mitochondrion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland273
ascites150
bladder33
blood81
bone209
bone marrow102
brain146
cervix288
connective tissue160
ear186
embryonic tissue295
esophagus99
eye239
heart134
intestine206
kidney90
larynx42
liver141
lung209
lymph112
lymph node111
mammary gland178
mouth136
muscle394
nerve193
ovary68
pancreas206
parathyroid339
pharynx98
pituitary gland181
placenta144
prostate242
salivary gland296
skin213
spleen112
stomach459
testis124
thymus12
thyroid85
umbilical cord145
uterus189
vascular116
Health State
TissuesTPM*
normal139
adrenal tumor632
bladder carcinoma170
breast (mammary gland) tumor247
cervical tumor347
chondrosarcoma241
colorectal tumor204
esophageal tumor115
gastrointestinal tumor337
germ cell tumor121
glioma102
head and neck tumor134
kidney tumor58
leukemia84
liver tumor208
lung tumor243
lymphoma110
non-neoplasia82
ovarian tumor78
pancreatic tumor247
primitive neuroectodermal tumor of the CNS157
prostate cancer394
retinoblastoma366
skin tumor199
soft tissue/muscle tissue tumor335
uterine tumor199
Developmental Stage
TissuesTPM*
adult157
embryoid body314
blastocyst325
neonate64
fetus118
infant340
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.9
adrenal gland29.6
appendix23.6
bone marrow23
cerebral cortex24.4
colon42.7
duodenum35.1
esophagus37.2
gallbladder14.2
heart muscle52.1
kidney31.8
liver12.7
lung18.5
lymph node16.2
ovary24.1
pancreas14.6
placenta21
prostate25.5
salivary gland23.6
skin22.5
small intestine31.8
spleen15.8
stomach23.5
testis21.1
thyroid gland16.4
urinary bladder16.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Low
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
nasopharynxHigh
oral mucosaMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*193245, gene) Voltage-dependent anion channel 2; VDAC2OMIM


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