Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P45974)
Protein (NX_P45974)
Protein
Gene SymbolUSP5 to neXtProt (NX_P45974)
DescriptionUbiquitin carboxyl-terminal hydrolase 5
Chromosome12
Location12p13.31 (6961292 ~ 6975796) to Ensembl
Sequene Features : Isoforms 2, Variants 82, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked deubiquitination
.positive regulation of proteasomal ubiquitin-dependent protein catabolic process
.ubiquitin-dependent protein catabolic process
.zinc ion binding
.omega peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.lysosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 82 21
2014-09-19protein level
2 67 21
2014-05-27protein level
2 67 22
2014-02-25protein level
2 66 22
2013-12-09protein level
2 48 22
2013-11-01protein level
2 44 19
2013-09-12protein level
2 44 19
2013-08-17protein level
2 44 19
2013-07-15protein level
2 30 8
2013-06-11protein level
2 30 8
2013-02-12protein level
2 10 15
2012-12-20protein level
2 9 15
2012-10-30protein level
2 13 15
2012-10-07protein level
2 13 8
2012-08-24protein level
2 13 8
2012-07-28protein level
2 13 8
2012-06-08protein level
2 28 8
2012-05-07protein level
2 17 8
2012-04-10protein level
2 17 8
2012-01-13protein level
2 16 8
2011-12-20protein level
2 16 8
2011-11-11protein level
2 16 8
2011-08-23protein level
2 16 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P45974-1
1 37 1 95725.0652
NX_P45974-2
1 37 1 93248.0959
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741277,EBI-473249 TADA3  
  .regulation of tubulin deacetylation
.positive regulation of transcription, DNA-templated
.histone H3 acetylation
  + 9 more...
.ligand-dependent nuclear receptor transcription coactivator activity
.protein domain specific binding
.ligand-dependent nuclear receptor binding
  + 2 more...
.mitotic spindle
.transcription factor TFTC complex
.STAGA complex
  + 4 more...
2 EBI-741277,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
3 EBI-741277,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
4 EBI-741277,EBI-9675724 TMEM239  
  .N/A .N/A .integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood49
bone83
bone marrow20
brain68
cervix103
connective tissue33
embryonic tissue140
esophagus49
eye134
heart44
intestine112
kidney47
larynx42
liver24
lung59
lymph744
lymph node33
mammary gland52
mouth15
muscle131
nerve321
ovary98
pancreas37
pituitary gland60
placenta60
prostate153
salivary gland197
skin170
spleen37
stomach10
testis57
thyroid42
tonsil117
uterus116
Health State
TissuesTPM*
normal44
breast (mammary gland) tumor85
cervical tumor115
chondrosarcoma60
colorectal tumor159
esophageal tumor57
gastrointestinal tumor33
germ cell tumor91
glioma167
head and neck tumor44
kidney tumor116
leukemia31
liver tumor52
lung tumor97
lymphoma498
non-neoplasia72
ovarian tumor52
pancreatic tumor76
primitive neuroectodermal tumor of the CNS275
prostate cancer240
retinoblastoma236
skin tumor279
soft tissue/muscle tissue tumor271
uterine tumor55
Developmental Stage
TissuesTPM*
adult69
embryoid body100
blastocyst244
fetus30
infant127
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.8
adrenal gland29.4
appendix26.1
bone marrow15.5
cerebral cortex44.7
colon25.1
duodenum21.6
esophagus35.9
gallbladder21
heart muscle25.9
kidney23.2
liver14.1
lung21.4
lymph node28.2
ovary18.2
pancreas8.8
placenta25.2
prostate26.3
salivary gland12.4
skin43.1
small intestine21.6
spleen21.4
stomach19.6
testis52
thyroid gland29
urinary bladder27.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601447, gene) Ubiquitin-specific protease 5; USP5OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center