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> Protein (NX_P45983)
Protein (NX_P45983)
Protein
Gene SymbolMAPK8 to neXtProt (NX_P45983)
DescriptionMitogen-activated protein kinase 8
Chromosome10
Location10q11.22 (49514698 ~ 49647403) to Ensembl
Sequene Features : Isoforms 5, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 54 6
2014-09-19protein level
5 45 6
2014-05-27protein level
5 45 7
2014-02-25protein level
4 45 7
2013-12-09protein level
4 41 7
2013-11-01protein level
4 40 5
2013-09-12protein level
4 40 4
2013-08-17protein level
4 40 4
2013-07-15protein level
4 30 3
2013-06-11protein level
4 30 3
2013-02-12protein level
4 13 40
2012-12-20protein level
4 13 40
2012-10-30protein level
4 13 40
2012-10-07protein level
4 13 10
2012-08-24protein level
4 13 10
2012-07-28protein level
4 13 10
2012-06-08protein level
4 17 10
2012-05-07protein level
4 6 10
2012-04-10protein level
4 6 10
2012-01-13protein level
4 11 10
2011-12-20protein level
4 11 10
2011-11-11protein level
4 11 10
2011-08-23protein level
4 11 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P45983-1
0 12 10 48264.2235
NX_P45983-2
0 12 10 44200.4664
NX_P45983-3
0 13 9 43993.3839
NX_P45983-4
0 13 9 48057.141
NX_P45983-5
1 8 8 35310.033
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-286483,EBI-492605 MAP2K7  
  .cellular response to sorbitol
.stress-activated MAPK cascade
.innate immune response
  + 22 more...
.protein phosphatase binding
.protein kinase binding
.enzyme binding
  + 6 more...
.cytosol
.cytoplasm
.nucleus
.intracellular
2 EBI-286483,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
3 EBI-286483,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
4 EBI-286483,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
5 EBI-286483,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
6 EBI-286483,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
7 EBI-286483,EBI-700771 BAD  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
8 EBI-286483,EBI-78404 MAPK8IP1  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of JNK cascade
.negative regulation of JUN kinase activity
  + 3 more...
.kinesin binding
.MAP-kinase scaffold activity
.protein kinase inhibitor activity
.perinuclear region of cytoplasm
.synapse
.dentate gyrus mossy fiber
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone13
brain1
cervix82
connective tissue6
embryonic tissue9
eye9
heart11
intestine12
kidney18
lung8
lymph node11
mammary gland19
mouth75
ovary19
pancreas14
prostate5
skin9
spleen18
stomach10
testis32
trachea19
uterus21
vascular58
Health State
TissuesTPM*
normal2
bladder carcinoma56
breast (mammary gland) tumor32
colorectal tumor8
gastrointestinal tumor8
germ cell tumor3
glioma9
head and neck tumor37
lung tumor29
non-neoplasia20
ovarian tumor26
primitive neuroectodermal tumor of the CNS15
skin tumor7
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult2
blastocyst16
fetus8
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.5
adrenal gland18.4
appendix22.4
bone marrow19.3
cerebral cortex30.1
colon23.3
duodenum28.3
esophagus29.2
gallbladder30.7
heart muscle18.6
kidney30.1
liver21
lung17.9
lymph node20.1
ovary33.1
pancreas14.3
placenta19.5
prostate22.6
salivary gland21.8
skin13.1
small intestine31.6
spleen15.7
stomach22.8
testis39.3
thyroid gland45
urinary bladder27.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601158, gene) Mitogen-activated protein kinase 8; MAPK8OMIM


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