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> Protein (NX_P45984)
Protein (NX_P45984)
Protein
Gene SymbolMAPK9 to neXtProt (NX_P45984)
DescriptionMitogen-activated protein kinase 9
Chromosome5
Location5q35.3 (179660143 ~ 179719099) to Ensembl
Sequene Features : Isoforms 5, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 60 3
2014-09-19protein level
5 49 3
2014-05-27protein level
5 49 4
2014-02-25protein level
5 48 4
2013-12-09protein level
5 41 4
2013-11-01protein level
5 40 3
2013-09-12protein level
5 40 3
2013-08-17protein level
5 40 3
2013-07-15protein level
5 32 2
2013-06-11protein level
5 32 2
2013-02-12protein level
5 15 12
2012-12-20protein level
5 15 12
2012-10-30protein level
5 17 12
2012-10-07protein level
5 17 3
2012-08-24protein level
5 10 3
2012-07-28protein level
5 10 3
2012-06-08protein level
5 12 3
2012-05-07protein level
5 12 3
2012-04-10protein level
5 12 3
2012-01-13protein level
5 13 3
2011-12-20protein level
5 13 3
2011-11-11protein level
5 13 3
2011-08-23protein level
4 13 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P45984-1
0 14 8 48107.9688
NX_P45984-2
0 14 8 44022.182
NX_P45984-3
0 13 9 44194.3179
NX_P45984-4
0 13 9 48280.1047
NX_P45984-5
2 5 7 27315.9068
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713568,EBI-10173195 SMCO3  
  .N/A .N/A .integral component of membrane
2 EBI-713568,EBI-714790 WDR62  
  .neurogenesis
.cerebral cortex development
.N/A .cytoplasm
.nucleoplasm
.nucleus
.spindle pole
3 EBI-713568,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
4 EBI-713568,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
5 EBI-713568,EBI-715117 SHMT1  
  .protein homotetramerization
.protein tetramerization
.folic acid metabolic process
  + 9 more...
.protein homodimerization activity
.pyridoxal phosphate binding
.amino acid binding
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
6 EBI-713586,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
7 EBI-713568,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
8 EBI-713568,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
9 EBI-713568,EBI-10171858 CTBP1  
  .negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
10 EBI-713568,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
11 EBI-713568,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
12 EBI-713568,EBI-946029 C1orf94  
  .N/A .N/A .N/A
13 EBI-713568,EBI-742397 TEX11  
  .chiasma assembly
.negative regulation of apoptotic process
.fertilization
  + 6 more...
.N/A .central element
14 EBI-713568,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
15 EBI-713568,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
16 EBI-713568,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood40
bone69
bone marrow41
brain49
cervix61
connective tissue53
embryonic tissue37
eye67
intestine64
kidney47
larynx42
liver34
lung62
lymph22
lymph node77
mammary gland52
muscle37
nerve64
ovary19
pancreas37
parathyroid97
placenta70
prostate31
skin37
stomach31
testis29
thymus12
thyroid21
tonsil58
trachea19
umbilical cord72
uterus25
vascular19
Health State
TissuesTPM*
normal53
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma96
colorectal tumor71
gastrointestinal tumor8
germ cell tumor18
glioma18
head and neck tumor14
kidney tumor43
leukemia52
liver tumor20
lung tumor38
lymphoma27
non-neoplasia51
ovarian tumor13
pancreatic tumor57
primitive neuroectodermal tumor of the CNS70
prostate cancer28
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult55
embryoid body42
blastocyst32
neonate32
fetus44
infant255
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland21.6
appendix17.7
bone marrow12.6
cerebral cortex48.7
colon23.3
duodenum15.1
esophagus15.3
gallbladder16
heart muscle21.2
kidney18.5
liver8.8
lung19.2
lymph node19.5
ovary14.6
pancreas21.4
placenta20
prostate20
salivary gland13.2
skin10.4
small intestine17.5
spleen15.8
stomach20.7
testis19.7
thyroid gland29.7
urinary bladder18.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602896, gene) Mitogen-activated protein kinase 9; MAPK9OMIM


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