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> Protein (NX_P46108)
Protein (NX_P46108)
Protein
Gene SymbolCRK to neXtProt (NX_P46108)
DescriptionAdapter molecule crk
Chromosome17
Location17p13.3 (1323983 ~ 1366456) to Ensembl
Sequene Features : Isoforms 2, Variants 22, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 22 10
2014-09-19protein level
2 12 10
2014-05-27protein level
2 12 10
2014-02-25protein level
2 12 10
2013-12-09protein level
2 10 10
2013-11-01protein level
2 10 9
2013-09-12protein level
2 10 8
2013-08-17protein level
2 10 8
2013-07-15protein level
2 9 8
2013-06-11protein level
2 9 8
2013-02-12protein level
2 5 15
2012-12-20protein level
2 5 15
2012-10-30protein level
2 6 15
2012-10-07protein level
2 6 9
2012-08-24protein level
2 4 9
2012-07-28protein level
2 4 9
2012-06-08protein level
2 8 9
2012-05-07protein level
2 8 9
2012-04-10protein level
2 8 9
2012-01-13protein level
2 7 9
2011-12-20protein level
2 7 9
2011-11-11protein level
2 7 9
2011-08-23protein level
2 7 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P46108-1
5 11 0 33809.9233
NX_P46108-2
1 11 0 22891.4735
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-886,EBI-356594 IRS4  
  .regulation of lipid metabolic process
.positive regulation of signal transduction
.insulin receptor signaling pathway
.signal transduction
.phosphatidylinositol 3-kinase binding
.insulin receptor binding
.SH3/SH2 adaptor activity
.signal transducer activity
.intracellular membrane-bounded organelle
.plasma membrane
.cytosol
2 EBI-886,EBI-311099 ARHGEF11  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 14 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.G-protein coupled receptor binding
.membrane
.cytosol
.cytoplasm
.intracellular
3 EBI-886,EBI-727209 SNX3  
  .negative regulation of early endosome to late endosome transport
.intralumenal vesicle formation
.negative regulation of protein transport
  + 13 more...
.phosphatidylinositol-3,5-bisphosphate binding
.phosphatidylinositol-4-phosphate binding
.phosphatidylinositol-3-phosphate binding
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.early phagosome
  + 7 more...
4 EBI-886,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
5 EBI-886,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
6 EBI-886,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
7 EBI-886,EBI-1028277 FGFR1  
  .regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
.regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
  + 51 more...
.protein homodimerization activity
.identical protein binding
.fibroblast growth factor binding
  + 4 more...
.receptor complex
.cytoplasmic membrane-bounded vesicle
.integral component of membrane
  + 5 more...
8 EBI-886,EBI-2861522 PDGFRA  
  .regulation of mesenchymal stem cell differentiation
.regulation of actin cytoskeleton reorganization
.metanephric glomerular capillary formation
  + 47 more...
.platelet-derived growth factor binding
.protein homodimerization activity
.vascular endothelial growth factor binding
  + 6 more...
.protein complex
.intrinsic component of plasma membrane
.membrane
  + 6 more...
9 EBI-886,EBI-1753690 OGN  
  .negative regulation of smooth muscle cell proliferation
.small molecule metabolic process
.keratan sulfate catabolic process
  + 4 more...
.N/A .extracellular exosome
.lysosomal lumen
.vesicle
  + 4 more...
10 EBI-886,EBI-350432 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
11 EBI-886,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
12 EBI-886,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
13 EBI-886,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
14 EBI-886,EBI-710431 PTPN4  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity .cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
15 EBI-886,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
16 EBI-886,EBI-1005487 KDR  
  .positive regulation of vasculogenesis
.negative regulation of endothelial cell apoptotic process
.positive regulation of ERK1 and ERK2 cascade
  + 39 more...
.Hsp90 protein binding
.vascular endothelial growth factor binding
.growth factor binding
  + 6 more...
.sorting endosome
.membrane raft
.cell junction
  + 10 more...
17 EBI-886,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
18 EBI-886,EBI-286483 MAPK8  
  .positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
19 EBI-886,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
20 EBI-886,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
21 EBI-886,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
22 EBI-886,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
23 EBI-886,EBI-298181 SOS2  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
24 EBI-886,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
25 EBI-886,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
26 EBI-886,EBI-976876 RAPGEF1  
  .negative regulation of neural precursor cell proliferation
.cellular response to nerve growth factor stimulus
.regulation of cell junction assembly
  + 17 more...
.Rap guanyl-nucleotide exchange factor activity .cytosol
.early endosome
.endosome
27 EBI-886,EBI-489954 FLNC  
  .muscle fiber development
.cell junction assembly
.ankyrin binding
.cytoskeletal protein binding
.costamere
.sarcolemma
.Z disc
  + 6 more...
28 EBI-886,EBI-1570523 RIN3  
  .positive regulation of GTPase activity
.signal transduction
.endocytosis
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.GTPase activator activity
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
.early endosome
29 EBI-886,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
30 EBI-886,EBI-881 MAP4K1  
  .protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
31 EBI-886,EBI-745641 ASB9  
  .positive regulation of protein catabolic process
.intracellular signal transduction
.protein ubiquitination
.N/A .mitochondrion
32 EBI-886,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
33 EBI-886,EBI-1570571 SHANK2  
  .vocalization behavior
.long term synaptic depression
.long-term synaptic potentiation
  + 6 more...
.ionotropic glutamate receptor binding
.GKAP/Homer scaffold activity
.ciliary membrane
.postsynaptic membrane
.dendritic spine
  + 12 more...
34 EBI-886,EBI-1279 MAP4K5  
  .regulation of apoptotic process
.intracellular signal transduction
.regulation of mitotic cell cycle
  + 3 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites100
blood32
bone41
bone marrow20
brain48
cervix20
connective tissue13
embryonic tissue46
eye52
heart11
intestine43
kidney14
liver34
lung17
lymph22
lymph node22
mammary gland66
mouth60
muscle9
ovary49
pancreas32
pharynx24
pituitary gland60
placenta63
skin33
spleen56
stomach10
testis36
thymus37
thyroid42
trachea19
uterus43
vascular96
Health State
TissuesTPM*
normal35
breast (mammary gland) tumor107
cervical tumor28
colorectal tumor17
gastrointestinal tumor59
germ cell tumor53
glioma37
head and neck tumor37
kidney tumor29
leukemia31
liver tumor72
lung tumor48
lymphoma13
ovarian tumor65
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
retinoblastoma43
skin tumor23
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult30
embryoid body42
blastocyst32
neonate32
fetus37
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39
adrenal gland22.7
appendix20.6
bone marrow3.4
cerebral cortex26.4
colon35.8
duodenum24.1
esophagus27.7
gallbladder32.6
heart muscle21.1
kidney27.3
liver26.5
lung30.3
lymph node17
ovary23.4
pancreas13.1
placenta37.7
prostate20.8
salivary gland17.5
skin16.7
small intestine22.7
spleen18.2
stomach24.3
testis22.9
thyroid gland39
urinary bladder32.3
Tissues
TissuesExpression level
appendixLow
bronchusLow
cervix, uterineMedium
colonMedium
duodenumHigh
esophagusMedium
gallbladderMedium
heart muscleLow
kidneyHigh
liverHigh
nasopharynxLow
oral mucosaMedium
pancreasMedium
placentaLow
prostateLow
rectumLow
salivary glandHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
stomach 2Low
tonsilMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164762, gene) V-crk avian sarcoma virus ct10 oncogene homolog; CRKOMIM


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