Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P46109)
Protein (NX_P46109)
Protein
Gene SymbolCRKL to neXtProt (NX_P46109)
DescriptionCrk-like protein
Chromosome22
Location22q11.21 (21271714 ~ 21308037) to Ensembl
Sequene Features : Isoforms 1, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 35 5
2014-09-19protein level
1 27 5
2014-05-27protein level
1 27 5
2014-02-25protein level
1 27 5
2013-12-09protein level
1 23 5
2013-11-01protein level
1 23 4
2013-09-12protein level
1 23 7
2013-08-17protein level
1 23 7
2013-07-15protein level
1 16 7
2013-06-11protein level
1 16 7
2013-02-12protein level
1 3 8
2012-12-20protein level
1 3 8
2012-10-30protein level
1 3 8
2012-10-07protein level
1 3 8
2012-08-24protein level
1 3 8
2012-07-28protein level
1 3 8
2012-06-08protein level
1 3 8
2012-05-07protein level
1 1 8
2012-04-10protein level
1 1 8
2012-01-13protein level
1 3 8
2011-12-20protein level
1 3 8
2011-11-11protein level
1 3 7
2011-08-23protein level
1 3 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P46109-1
14 0 0 33755.8273
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-910,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-910,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-910,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
4 EBI-910,EBI-2861522 PDGFRA  
  .regulation of mesenchymal stem cell differentiation
.regulation of actin cytoskeleton reorganization
.metanephric glomerular capillary formation
  + 47 more...
.platelet-derived growth factor binding
.protein homodimerization activity
.vascular endothelial growth factor binding
  + 6 more...
.protein complex
.intrinsic component of plasma membrane
.membrane
  + 6 more...
5 EBI-910,EBI-1026718 FLT1  
  .embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
6 EBI-910,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
7 EBI-910,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
8 EBI-910,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
9 EBI-910,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
10 EBI-910,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
11 EBI-910,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
12 EBI-910,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
13 EBI-910,EBI-976876 RAPGEF1  
  .negative regulation of neural precursor cell proliferation
.cellular response to nerve growth factor stimulus
.regulation of cell junction assembly
  + 17 more...
.Rap guanyl-nucleotide exchange factor activity .cytosol
.early endosome
.endosome
14 EBI-910,EBI-881 MAP4K1  
  .protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
15 EBI-910,EBI-8536103 DCBLD2  
  .wound healing
.intracellular receptor signaling pathway
.negative regulation of cell growth
.N/A .cell surface
.integral component of plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites75
bladder133
blood32
bone69
bone marrow164
brain83
cervix20
connective tissue80
ear124
embryonic tissue112
eye86
heart44
intestine64
kidney61
liver29
lung59
lymph45
lymph node100
mammary gland72
mouth120
muscle56
nerve128
ovary19
pancreas65
parathyroid145
pharynx73
pituitary gland60
placenta56
prostate137
salivary gland98
skin71
spleen18
stomach292
testis59
thymus138
thyroid21
trachea77
uterus94
Health State
TissuesTPM*
normal90
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma108
colorectal tumor53
gastrointestinal tumor118
germ cell tumor68
glioma37
head and neck tumor82
kidney tumor101
leukemia74
liver tumor41
lung tumor9
lymphoma41
non-neoplasia41
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS55
prostate cancer221
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor87
uterine tumor66
Developmental Stage
TissuesTPM*
adult88
embryoid body57
blastocyst146
fetus82
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.7
adrenal gland14.8
appendix18.3
bone marrow32.5
cerebral cortex30.2
colon18.3
duodenum19.5
esophagus22.6
gallbladder16
heart muscle19.8
kidney14.9
liver13.7
lung19.8
lymph node25.1
ovary26.4
pancreas11.5
placenta26.6
prostate14.6
salivary gland11
skin17.9
small intestine17.5
spleen20.6
stomach14.2
testis15.3
thyroid gland15.7
urinary bladder21.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602007, gene) V-crk avian sarcoma virus ct10 oncogene homolog-like; CRKLOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center