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> Protein (NX_P46379)
Protein (NX_P46379)
Protein
Gene SymbolBAG6 to neXtProt (NX_P46379)
DescriptionLarge proline-rich protein BAG6
Chromosome6
Location6p21.33 (31606805 ~ 31620482) to Ensembl
Sequene Features : Isoforms 5, Variants 84, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.tail-anchored membrane protein insertion into ER membrane
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.protein stabilization
  + 17 more...
.proteasome binding
.ribosome binding
.ubiquitin protein ligase binding
.polyubiquitin binding
.BAT3 complex
.intracellular membrane-bounded organelle
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 84 15
2014-09-19protein level
5 57 15
2014-05-27protein level
5 57 15
2014-02-25protein level
5 30 15
2013-12-09protein level
5 11 15
2013-11-01protein level
5 11 12
2013-09-12protein level
5 11 12
2013-08-17protein level
5 11 12
2013-07-15protein level
5 11 7
2013-06-11protein level
5 11 7
2013-02-12protein level
3 11 28
2012-12-20protein level
3 14 28
2012-10-30protein level
3 19 28
2012-10-07protein level
3 19 10
2012-08-24protein level
3 19 10
2012-07-28protein level
3 19 14
2012-06-08protein level
3 28 10
2012-05-07protein level
3 28 10
2012-04-10protein level
3 19 10
2012-01-13protein level
3 13 10
2011-12-20protein level
3 13 10
2011-11-11protein level
3 13 10
2011-08-23protein level
3 13 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P46379-1
1 37 0 119333.6367
NX_P46379-2
0 37 0 118618.2482
NX_P46379-3
1 36 0 122265.113
NX_P46379-4
2 30 0 96738.6666
NX_P46379-5
0 34 0 113384.6208
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347552,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-347552,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
3 EBI-347552,EBI-536772 EFEMP1  
  .negative regulation of chondrocyte differentiation
.extracellular matrix organization
.peptidyl-tyrosine phosphorylation
  + 3 more...
.calcium ion binding
.epidermal growth factor receptor binding
.epidermal growth factor-activated receptor activity
.extracellular exosome
.extracellular space
.proteinaceous extracellular matrix
.extracellular region
4 EBI-347552,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
5 EBI-347552,EBI-995373 MAVS  
  .regulation of peroxisome organization
.positive regulation of IP-10 production
.positive regulation of chemokine (C-C motif) ligand 5 production
  + 22 more...
.CARD domain binding
.protein kinase binding
.signal transducer activity
.mitochondrial membrane
.integral component of membrane
.peroxisomal membrane
  + 2 more...
6 EBI-347552,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
7 EBI-347552,EBI-357322 RNF126  
  .cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 7 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites251
bladder66
blood171
bone153
bone marrow82
brain93
cervix288
connective tissue93
embryonic tissue352
eye258
heart178
intestine168
kidney113
liver116
lung200
lymph293
lymph node267
mammary gland171
mouth90
muscle103
nerve386
ovary374
pancreas103
parathyroid48
pharynx73
pituitary gland121
placenta144
prostate105
salivary gland49
skin313
spleen37
stomach41
testis436
thymus50
thyroid214
tonsil411
umbilical cord145
uterus112
vascular38
Health State
TissuesTPM*
normal123
adrenal tumor158
breast (mammary gland) tumor204
cervical tumor318
chondrosarcoma338
colorectal tumor186
gastrointestinal tumor135
germ cell tumor125
glioma158
head and neck tumor97
kidney tumor217
leukemia105
liver tumor197
lung tumor350
lymphoma290
non-neoplasia93
ovarian tumor406
pancreatic tumor190
primitive neuroectodermal tumor of the CNS322
prostate cancer154
retinoblastoma732
skin tumor398
soft tissue/muscle tissue tumor143
uterine tumor110
Developmental Stage
TissuesTPM*
adult155
embryoid body357
blastocyst471
fetus105
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75.1
adrenal gland73
appendix85.9
bone marrow72.5
cerebral cortex52.7
colon75.3
duodenum83.4
esophagus73.4
gallbladder69.7
heart muscle89.7
kidney64.5
liver51.7
lung87.2
lymph node92.5
ovary82.5
pancreas37.2
placenta79.9
prostate73.2
salivary gland75.3
skin106.4
small intestine81.9
spleen103.8
stomach64.7
testis214.5
thyroid gland75.6
urinary bladder68.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*142590, gene) Bcl2-associated athanogene 6; BAG6OMIM


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