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> Protein (NX_P46459)
Protein (NX_P46459)
Protein
Gene SymbolNSF to neXtProt (NX_P46459)
DescriptionVesicle-fusing ATPase
Chromosome17
Location17q21.31 (44668035 ~ 44834830) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Golgi vesicle docking
.ATP metabolic process
.positive regulation of protein catabolic process
  + 10 more...
.metal ion binding
.ATPase activity, coupled
.protein complex binding
  + 6 more...
.extracellular exosome
.dendritic shaft
.postsynaptic density
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 5
2014-09-19protein level
1 21 5
2014-05-27protein level
1 21 5
2014-02-25protein level
1 21 4
2013-12-09protein level
1 19 4
2013-11-01protein level
1 19 4
2013-09-12protein level
1 19 4
2013-08-17protein level
1 19 4
2013-07-15protein level
1 8 3
2013-06-11protein level
1 8 3
2013-02-12protein level
1 1 3
2012-12-20protein level
1 1 3
2012-10-30protein level
1 4 2
2012-10-07protein level
1 4 2
2012-08-24protein level
1 4 2
2012-07-28protein level
1 4 2
2012-06-08protein level
1 15 2
2012-05-07protein level
1 15 2
2012-04-10protein level
1 15 2
2012-01-13protein level
1 17 2
2011-12-20protein level
1 17 2
2011-11-11protein level
1 17 1
2011-08-23protein level
1 17 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P46459-1
6 33 0 82541.8379
NX_P46459-2
1 33 0 71538.3755
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712251,EBI-715469 GABBR2  
  .synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.neuron projection
.G-protein coupled receptor heterodimeric complex
  + 4 more...
2 EBI-712251,EBI-3909876 GRIA2  
  .synaptic transmission, glutamatergic
.ionotropic glutamate receptor signaling pathway
.ion transmembrane transport
  + 2 more...
.extracellular-glutamate-gated ion channel activity
.alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
.ionotropic glutamate receptor activity
.postsynaptic membrane
.alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
.endocytic vesicle membrane
  + 6 more...
3 EBI-712251,EBI-742898 PTPN9  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
4 EBI-712251,EBI-749652 NAPA  
  .membrane fusion
.membrane organization
.apical protein localization
  + 8 more...
.syntaxin binding
.soluble NSF attachment protein activity
.extracellular exosome
.synaptobrevin 2-SNAP-25-syntaxin-1a complex
.SNARE complex
  + 3 more...
5 EBI-712251,EBI-724156 GABBR1  
  .synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.presynaptic membrane
.G-protein coupled receptor heterodimeric complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites251
bladder66
blood57
bone41
bone marrow41
brain843
cervix103
connective tissue248
ear124
embryonic tissue14
eye81
heart122
intestine38
kidney66
liver38
lung68
lymph22
lymph node66
mammary gland52
mouth302
muscle9
nerve64
ovary9
pancreas14
parathyroid145
pharynx73
pituitary gland242
placenta52
prostate5
salivary gland49
skin90
spleen37
stomach31
testis147
thymus62
trachea193
uterus60
vascular19
Health State
TissuesTPM*
normal296
adrenal tumor79
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma84
colorectal tumor35
gastrointestinal tumor109
germ cell tumor117
glioma27
head and neck tumor134
kidney tumor101
leukemia42
liver tumor52
lung tumor97
lymphoma13
non-neoplasia124
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
retinoblastoma64
skin tumor23
soft tissue/muscle tissue tumor239
uterine tumor11
Developmental Stage
TissuesTPM*
adult83
embryoid body28
blastocyst16
neonate32
fetus86
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.6
adrenal gland19.4
appendix18.6
bone marrow6.5
cerebral cortex141.7
colon26.2
duodenum12.3
esophagus22.5
gallbladder15.6
heart muscle8.7
kidney15.5
liver7.5
lung11.9
lymph node16.4
ovary7.4
pancreas12
placenta14.6
prostate17
salivary gland15.9
skin11.7
small intestine15.2
spleen12.2
stomach18.4
testis20.1
thyroid gland17.9
urinary bladder19.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleHigh
liverLow
lungLow
lymph nodeLow
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601633, gene) N-ethylmaleimide-sensitive factor; NSFOMIM


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