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> Protein (NX_P46527)
Protein (NX_P46527)
Protein
Gene SymbolCDKN1B to neXtProt (NX_P46527)
DescriptionCyclin-dependent kinase inhibitor 1B
Chromosome12
Location12p13.1 (12867992 ~ 12875305) to Ensembl
Sequene Features : Isoforms 1, Variants 35, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 35 10
2014-09-19protein level
1 29 10
2014-05-27protein level
1 29 10
2014-02-25protein level
1 29 10
2013-12-09protein level
1 22 10
2013-11-01protein level
1 22 10
2013-09-12protein level
1 22 9
2013-08-17protein level
1 22 9
2013-07-15protein level
1 11 9
2013-06-11protein level
1 11 9
2013-02-12protein level
1 10 8
2012-12-20protein level
1 9 8
2012-10-30protein level
1 13 8
2012-10-07protein level
1 13 8
2012-08-24protein level
1 12 8
2012-07-28protein level
1 12 8
2012-06-08protein level
1 27 8
2012-05-07protein level
1 24 8
2012-04-10protein level
1 24 8
2012-01-13protein level
1 19 8
2011-12-20protein level
1 19 8
2011-11-11protein level
1 19 8
2011-08-23protein level
1 19 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P46527-1
11 0 0 22059.6659
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-519280,EBI-358297 KPNA3  
  .viral penetration into host nucleus
.viral entry into host cell
.cytokine-mediated signaling pathway
  + 2 more...
.protein transporter activity
.nuclear localization sequence binding
.cytosol
.nucleoplasm
.nuclear pore
2 EBI-519280,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-519280,EBI-540602 KPNA5  
  .cytokine-mediated signaling pathway
.NLS-bearing protein import into nucleus
.protein transporter activity .cytosol
.cytoplasm
.nucleoplasm
4 EBI-519280,EBI-375033 CCNE2  
  .cell division
.DNA replication initiation
.mitotic cell cycle
  + 3 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .cytosol
.nucleoplasm
5 EBI-519280,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
6 EBI-519280,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
7 EBI-519280,EBI-457097 CCNA2  
  .cell division
.positive regulation of fibroblast proliferation
.positive regulation of transcription, DNA-templated
  + 11 more...
.N/A .cytoplasm
.nucleoplasm
.nucleus
  + 2 more...
8 EBI-519280,EBI-375001 CCND1  
  .negative regulation of cell cycle arrest
.response to UV-A
.mammary gland alveolus development
  + 34 more...
.proline-rich region binding
.histone deacetylase binding
.protein kinase binding
  + 5 more...
.transcriptional repressor complex
.membrane
.tight junction
  + 5 more...
9 EBI-519280,EBI-519526 CCNE1  
  .regulation of cell cycle
.cell division
.positive regulation of transcription, DNA-templated
  + 7 more...
.androgen receptor binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.transcription coactivator activity
.cytosol
.nucleoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
10 EBI-519280,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
11 EBI-519280,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
12 EBI-519280,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
13 EBI-519280,EBI-1041567 CDK5  
  .positive regulation of actin cytoskeleton reorganization
.regulation of synaptic vesicle recycling
.negative regulation of neuron death
  + 63 more...
.tau-protein kinase activity
.ErbB-3 class receptor binding
.acetylcholine receptor activator activity
  + 6 more...
.postsynaptic membrane
.perikaryon
.neuronal cell body
  + 14 more...
14 EBI-519280,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
15 EBI-519280,EBI-456291 SKP2  
  .cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
16 EBI-519280,EBI-594661 COPS5  
  .exosomal secretion
.regulation of IRE1-mediated unfolded protein response
.regulation of cell cycle
  + 8 more...
.metal ion binding
.metallopeptidase activity
.ubiquitin-specific protease activity
  + 2 more...
.perinuclear region of cytoplasm
.cell junction
.COP9 signalosome
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites25
bladder133
blood89
bone55
bone marrow20
brain173
cervix144
connective tissue60
ear372
embryonic tissue32
esophagus248
eye52
heart78
intestine60
kidney104
liver53
lung35
lymph node44
mammary gland79
mouth136
muscle28
nerve193
ovary78
pancreas46
parathyroid48
pituitary gland121
placenta52
prostate36
skin18
spleen168
stomach41
testis55
thymus288
trachea212
uterus90
vascular96
Health State
TissuesTPM*
normal94
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor75
cervical tumor173
chondrosarcoma60
colorectal tumor44
esophageal tumor289
gastrointestinal tumor33
germ cell tumor113
glioma46
head and neck tumor44
kidney tumor174
leukemia21
liver tumor83
lymphoma13
non-neoplasia31
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS94
prostate cancer28
retinoblastoma21
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult60
embryoid body28
neonate96
fetus149
infant127
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.2
adrenal gland38.6
appendix33.7
bone marrow34.9
cerebral cortex36.6
colon28.6
duodenum34
esophagus18.9
gallbladder23.9
heart muscle22.1
kidney27.4
liver16.7
lung29.4
lymph node44
ovary52.1
pancreas9.4
placenta29.6
prostate32.2
salivary gland22.5
skin20.8
small intestine31.1
spleen43.2
stomach25.4
testis26.2
thyroid gland27.1
urinary bladder34.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600778, gene) Cyclin-dependent kinase inhibitor 1b; CDKN1BOMIM
2(#610755, phenotype) Multiple endocrine neoplasia, type iv; MEN4OMIM


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