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> Protein (NX_P46934)
Protein (NX_P46934)
Protein
Gene SymbolNEDD4 to neXtProt (NX_P46934)
DescriptionE3 ubiquitin-protein ligase NEDD4
Chromosome15
Location15q21.3 (56119120 ~ 56285944) to Ensembl
Sequene Features : Isoforms 4, Variants 164, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of sodium ion transmembrane transporter activity
.regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
  + 32 more...
.proline-rich region binding
.RNA polymerase binding
.ubiquitin protein ligase activity
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apicolateral plasma membrane
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 164 4
2014-09-19protein level
4 133 4
2014-05-27protein level
4 133 4
2014-02-25protein level
4 133 4
2013-12-09protein level
4 105 4
2013-11-01protein level
4 101 3
2013-09-12protein level
4 101 3
2013-08-17protein level
4 101 3
2013-07-15protein level
4 69 3
2013-06-11protein level
4 69 3
2013-02-12protein level
4 39 12
2012-12-20protein level
4 37 12
2012-10-30protein level
4 48 12
2012-10-07protein level
4 48 3
2012-08-24protein level
4 36 3
2012-07-28protein level
4 36 3
2012-06-08protein level
4 42 3
2012-05-07protein level
4 42 3
2012-04-10protein level
4 42 3
2012-01-13protein level
4 26 3
2011-12-20protein level
4 26 3
2011-11-11protein level
4 26 3
2011-08-23protein level
4 26 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P46934-1
0 56 5 149021.1277
NX_P46934-2
1 55 5 147291.3078
NX_P46934-3
1 52 5 140607.8857
NX_P46934-4
5 32 6 104151.8064
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-726944,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-726944,EBI-1028277 FGFR1  
  .regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
.regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
  + 51 more...
.protein homodimerization activity
.identical protein binding
.fibroblast growth factor binding
  + 4 more...
.receptor complex
.cytoplasmic membrane-bounded vesicle
.integral component of membrane
  + 5 more...
3 EBI-726944,EBI-2547187 SCNN1B  
  .transmembrane transport
.sodium ion homeostasis
.sensory perception of taste
  + 6 more...
.WW domain binding
.ligand-gated sodium channel activity
.extracellular exosome
.sodium channel complex
.cytoplasmic vesicle membrane
  + 4 more...
4 EBI-726944,EBI-696162 PTEN  
  .positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
5 EBI-726944,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
6 EBI-726944,EBI-725647 LITAF  
  .cellular response to lipopolysaccharide
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of NF-kappaB import into nucleus
  + 6 more...
.WW domain binding
.signal transducer activity
.intracellular membrane-bounded organelle
.plasma membrane
.Golgi apparatus
  + 3 more...
7 EBI-726944,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
8 EBI-726944,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder267
blood8
bone69
bone marrow20
brain7
connective tissue26
embryonic tissue56
esophagus49
eye19
heart22
intestine12
kidney33
liver189
lung14
lymph22
lymph node11
mammary gland66
mouth30
muscle84
pancreas4
pituitary gland60
placenta31
salivary gland49
skin28
stomach31
testis13
trachea19
uterus12
vascular193
Health State
TissuesTPM*
normal29
adrenal tumor79
breast (mammary gland) tumor32
chondrosarcoma96
colorectal tumor17
esophageal tumor57
gastrointestinal tumor33
germ cell tumor11
glioma37
head and neck tumor14
leukemia21
liver tumor343
lung tumor9
lymphoma27
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult30
embryoid body71
blastocyst48
neonate96
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.2
adrenal gland4.1
appendix5.4
bone marrow5.3
cerebral cortex2.3
colon4.6
duodenum5.1
esophagus6.1
gallbladder7.9
heart muscle4.9
kidney7.7
liver22.3
lung6.2
lymph node3.9
ovary4.9
placenta15.4
prostate6.6
salivary gland1.4
skin8.1
small intestine8.5
spleen4.3
stomach2.3
testis3.2
thyroid gland11.5
urinary bladder9.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602278, gene) Neural precursor cell expressed, developmentally downregulated 4;OMIM


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