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> Protein (NX_P46940)
Protein (NX_P46940)
Protein
Gene SymbolIQGAP1 to neXtProt (NX_P46940)
DescriptionRas GTPase-activating-like protein IQGAP1
Chromosome15
Location15q26.1 (90931450 ~ 91045475) to Ensembl
Sequene Features : Isoforms 1, Variants 158, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 158 21
2014-09-19protein level
1 129 21
2014-05-27protein level
1 129 23
2014-02-25protein level
1 130 23
2013-12-09protein level
1 110 23
2013-11-01protein level
1 103 15
2013-09-12protein level
1 103 15
2013-08-17protein level
1 103 15
2013-07-15protein level
1 77 12
2013-06-11protein level
1 77 12
2013-02-12protein level
1 43 9
2012-12-20protein level
1 41 9
2012-10-30protein level
1 52 9
2012-10-07protein level
1 52 9
2012-08-24protein level
1 47 9
2012-07-28protein level
1 47 9
2012-06-08protein level
1 52 9
2012-05-07protein level
1 32 9
2012-04-10protein level
1 32 9
2012-01-13protein level
1 11 9
2011-12-20protein level
1 11 9
2011-11-11protein level
1 11 9
2011-08-23protein level
1 11 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P46940-1
71 0 3 189133.2543
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297509,EBI-6897823 PODXL  
  .epithelial tube formation
.glomerular visceral epithelial cell development
.leukocyte migration
  + 7 more...
.N/A .extracellular exosome
.membrane raft
.cell body
  + 10 more...
2 EBI-297509,EBI-351526 ACTN4  
  .regulation of nucleic acid-templated transcription
.protein localization to tight junction
.tight junction assembly
  + 13 more...
.actin filament binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.protein complex
  + 13 more...
3 EBI-297509,EBI-8838062 PIP5K1C  
  .clathrin-mediated endocytosis
.platelet aggregation
.synaptic vesicle endocytosis
  + 11 more...
.1-phosphatidylinositol-4-phosphate 5-kinase activity
.ATP binding
.ruffle membrane
.endomembrane system
.focal adhesion
  + 4 more...
4 EBI-297509,EBI-996920 NPHS1  
  .glomerular visceral epithelial cell development
.regulation of excretion
.glomerular basement membrane development
  + 6 more...
.myosin binding .extracellular exosome
.membrane raft
.protein complex
  + 4 more...
5 EBI-297509,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
6 EBI-297509,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
7 EBI-297509,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
8 EBI-297509,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
9 EBI-297509,EBI-8390477 RNASEL  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.type I interferon signaling pathway
.transmembrane transport
  + 7 more...
.metal ion binding
.rRNA binding
.ATP binding
  + 3 more...
.nuclear matrix
.cytosol
.mitochondrial matrix
10 EBI-297509,EBI-924464 MAGI1  
  .neuron death
.cell surface receptor signaling pathway
.cell adhesion
.protein complex assembly
.alpha-actinin binding
.protein C-terminus binding
.ATP binding
.cell projection
.cell junction
.tight junction
  + 4 more...
11 EBI-297509,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
12 EBI-297509,EBI-6897706 NPHS2  
  .metanephric glomerular visceral epithelial cell development
.actin cytoskeleton reorganization
.excretion
.N/A .extracellular exosome
.membrane raft
.protein complex
  + 6 more...
13 EBI-297509,EBI-298152 CD2AP  
  .regulation of actin cytoskeleton reorganization
.positive regulation of protein localization to nucleus
.cell division
  + 5 more...
.SH3 domain binding
.structural constituent of cytoskeleton
.extracellular exosome
.filamentous actin
.actin cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland60
ascites125
bladder167
blood204
bone139
bone marrow82
brain54
cervix41
connective tissue221
embryonic tissue70
esophagus347
eye38
heart78
intestine176
kidney166
larynx383
liver185
lung125
lymph90
lymph node200
mammary gland502
mouth513
muscle235
ovary177
pancreas117
parathyroid97
pharynx392
pituitary gland121
placenta222
prostate126
skin118
spleen131
stomach125
testis39
thymus112
thyroid171
tonsil58
trachea289
uterus215
vascular348
Health State
TissuesTPM*
normal136
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor193
cervical tumor57
chondrosarcoma181
colorectal tumor213
esophageal tumor405
gastrointestinal tumor118
germ cell tumor79
glioma37
head and neck tumor418
kidney tumor130
leukemia158
liver tumor166
lung tumor126
lymphoma110
non-neoplasia155
ovarian tumor210
pancreatic tumor104
primitive neuroectodermal tumor of the CNS23
prostate cancer125
skin tumor111
soft tissue/muscle tissue tumor79
uterine tumor177
Developmental Stage
TissuesTPM*
adult203
embryoid body85
blastocyst81
neonate96
fetus87
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue64.5
adrenal gland54.6
appendix87.7
bone marrow61.1
cerebral cortex15.9
colon95
duodenum35.8
esophagus85.2
gallbladder78.3
heart muscle22.5
kidney40.6
liver19
lung87.4
lymph node85.7
ovary45.5
pancreas19.7
placenta84.6
prostate53.4
salivary gland82.4
skin92.5
small intestine45.5
spleen72.8
stomach64.5
testis21
thyroid gland76.5
urinary bladder72.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
kidneyMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603379, gene) Iq motif-containing gtpase-activating protein 1; IQGAP1OMIM


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