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> Protein (NX_P48023)
Protein (NX_P48023)
Protein
Gene SymbolFASLG to neXtProt (NX_P48023)
DescriptionTumor necrosis factor ligand superfamily member 6
Chromosome1
Location1q24.3 (172628154 ~ 172636014) to Ensembl
Sequene Features : Isoforms 2, Variants 61, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 61 4
2014-09-19protein level
2 39 4
2014-05-27protein level
2 39 4
2014-02-25protein level
2 39 4
2013-12-09protein level
2 39 4
2013-11-01protein level
2 38 4
2013-09-12protein level
2 38 4
2013-08-17protein level
2 38 4
2013-07-15protein level
2 27 4
2013-06-11protein level
2 27 4
2013-02-12protein level
2 12 4
2012-12-20protein level
2 8 4
2012-10-30protein level
2 10 4
2012-10-07protein level
2 10 4
2012-08-24protein level
2 10 4
2012-07-28protein level
2 10 4
2012-06-08protein level
2 13 4
2012-05-07protein level
2 10 4
2012-04-10protein level
2 10 4
2012-01-13protein level
2 12 4
2011-12-20protein level
2 12 4
2011-11-11protein level
2 12 4
2011-08-23protein level
2 12 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P48023-1
8 3 0 31464.0218
NX_P48023-2
1 3 0 13996.482
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-495538,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-495538,EBI-1051034 SRGAP2  
  .negative regulation of neuron migration
.dendritic spine development
.regulation of small GTPase mediated signal transduction
  + 9 more...
.Rac GTPase binding
.protein homodimerization activity
.GTPase activator activity
.phagocytic vesicle
.postsynaptic membrane
.dendritic spine head
  + 7 more...
3 EBI-495538,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
4 EBI-495538,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
5 EBI-495538,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
6 EBI-495538,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
7 EBI-495538,EBI-968552 ITK  
  .T cell receptor signaling pathway
.innate immune response
.regulation of cell proliferation
  + 13 more...
.metal ion binding
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
.cytosol
8 EBI-495538,EBI-494804 FADD  
  .positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 49 more...
.identical protein binding
.death effector domain binding
.tumor necrosis factor receptor superfamily binding
  + 2 more...
.ripoptosome
.membrane raft
.cell body
  + 4 more...
9 EBI-495538,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
10 EBI-495538,EBI-739936 TRIP10  
  .regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
.small GTPase mediated signal transduction
  + 3 more...
.identical protein binding
.lipid binding
.extracellular exosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 9 more...
11 EBI-495538,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
12 EBI-495538,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
13 EBI-495538,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
14 EBI-495538,EBI-2481535 SNX33  
  .positive regulation of protein localization to cell surface
.negative regulation of protein localization to cell surface
.membrane tubulation
  + 12 more...
.identical protein binding
.phosphatidylinositol binding
.cytoplasmic vesicle membrane
.extrinsic component of membrane
.cytoplasmic membrane-bounded vesicle
  + 3 more...
15 EBI-495538,EBI-1111248 FNBP1  
  .endocytosis .identical protein binding
.lipid binding
.cytoplasmic membrane-bounded vesicle
.cell cortex
.coated pit
  + 3 more...
16 EBI-495538,EBI-721769 PACSIN1  
  .positive regulation of dendrite development
.membrane tubulation
.establishment of protein localization to plasma membrane
  + 7 more...
.cytoskeletal protein binding
.phospholipid binding
.perinuclear region of cytoplasm
.synapse
.axon terminus
  + 11 more...
17 EBI-495538,EBI-77926 PACSIN3  
  .membrane tubulation
.negative regulation of calcium ion transport
.positive regulation of membrane protein ectodomain proteolysis
  + 4 more...
.calcium channel inhibitor activity
.lipid binding
.cytoskeletal protein binding
.phospholipid binding
.extracellular exosome
.membrane-bounded vesicle
.membrane
  + 4 more...
18 EBI-495538,EBI-742503 PACSIN2  
  .membrane tubulation
.caveolin-mediated endocytosis
.caveola assembly
  + 5 more...
.phosphatidic acid binding
.identical protein binding
.cytoskeletal protein binding
.transporter activity
.extracellular exosome
.recycling endosome membrane
.intracellular membrane-bounded organelle
  + 12 more...
19 EBI-495538,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone marrow20
intestine4
prostate5
spleen18
uterus4
Health State
TissuesTPM*
normal3
lymphoma13
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
bone marrow1.6
duodenum1.4
gallbladder1.1
lung2.2
lymph node4.9
small intestine1.3
spleen3.1
stomach1.4
urinary bladder1.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*134638, gene) Tumor necrosis factor ligand superfamily, member 6; TNFSF6OMIM
2(#601859, phenotype) Autoimmune lymphoproliferative syndrome; ALPSOMIM


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