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> Protein (NX_P48047)
Protein (NX_P48047)
Protein
Gene SymbolATP5O to neXtProt (NX_P48047)
DescriptionATP synthase subunit O, mitochondrial
Chromosome21
Location21q22.11 (35275757 ~ 35288284) to Ensembl
Sequene Features : Isoforms 1, Variants 33, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 33 27
2014-09-19protein level
1 26 27
2014-05-27protein level
1 26 27
2014-02-25protein level
1 25 23
2013-12-09protein level
1 14 23
2013-11-01protein level
1 14 10
2013-09-12protein level
1 14 9
2013-08-17protein level
1 14 9
2013-07-15protein level
1 11 9
2013-06-11protein level
1 11 9
2013-02-12protein level
1 9 9
2012-12-20protein level
1 9 9
2012-10-30protein level
1 14 9
2012-10-07protein level
1 14 9
2012-08-24protein level
1 12 9
2012-07-28protein level
1 12 9
2012-06-08protein level
1 12 9
2012-05-07protein level
1 12 9
2012-04-10protein level
1 12 9
2012-01-13protein level
1 4 9
2011-12-20protein level
1 4 9
2011-11-11protein level
1 4 9
2011-08-23protein level
1 4 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P48047-1
11 0 0 23262.5895
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355815,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-355815,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-355815,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-355815,EBI-742084 NT5C2  
  .nucleobase-containing small molecule metabolic process
.adenosine metabolic process
.IMP metabolic process
  + 6 more...
.nucleoside phosphotransferase activity
.metal ion binding
.5'-nucleotidase activity
.nucleotide binding
.cytosol
5 EBI-355815,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
6 EBI-355815,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
7 EBI-355815,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
8 EBI-355815,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
9 EBI-355815,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
10 EBI-355815,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
11 EBI-355815,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
12 EBI-355815,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland364
ascites225
bladder133
blood188
bone41
bone marrow246
brain81
cervix185
connective tissue46
ear124
embryonic tissue178
eye181
heart435
intestine99
kidney56
liver97
lung152
lymph112
lymph node89
mammary gland99
mouth75
muscle310
nerve128
ovary128
pancreas163
parathyroid485
pharynx245
pituitary gland302
placenta84
prostate121
salivary gland246
skin118
spleen37
stomach229
testis96
thymus50
thyroid42
tonsil470
umbilical cord799
uterus129
vascular212
Health State
TissuesTPM*
normal138
adrenal tumor395
bladder carcinoma170
breast (mammary gland) tumor118
cervical tumor202
chondrosarcoma60
colorectal tumor97
gastrointestinal tumor160
germ cell tumor125
glioma130
head and neck tumor82
kidney tumor58
leukemia127
liver tumor41
lung tumor126
lymphoma166
non-neoplasia62
ovarian tumor170
pancreatic tumor66
primitive neuroectodermal tumor of the CNS78
prostate cancer134
retinoblastoma172
skin tumor79
soft tissue/muscle tissue tumor127
uterine tumor110
Developmental Stage
TissuesTPM*
adult133
embryoid body142
blastocyst113
neonate354
fetus140
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue126.1
adrenal gland137.6
appendix112
bone marrow139
cerebral cortex118.5
colon207.7
duodenum226.5
esophagus181.6
gallbladder114.5
heart muscle553.5
kidney209.9
liver121.8
lung95.8
lymph node162.1
ovary180.2
pancreas68.6
placenta118
prostate102.5
salivary gland128.1
skin111
small intestine194.3
spleen94.9
stomach169.6
testis99
thyroid gland152.7
urinary bladder161
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600828, gene) Atp synthase, h+ transporting, mitochondrial f1 complex, o subunit;OMIM


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