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> Protein (NX_P48059)
Protein (NX_P48059)
Protein
Gene SymbolLIMS1 to neXtProt (NX_P48059)
DescriptionLIM and senescent cell antigen-like-containing domain protein 1
Chromosome2
Location2q12.3 (109150857 ~ 109303702) to Ensembl
Sequene Features : Isoforms 5, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of substrate adhesion-dependent cell spreading
.cellular response to transforming growth factor beta stimulus
.positive regulation of focal adhesion assembly
  + 7 more...
.protein kinase binding
.zinc ion binding
.perinuclear region of cytoplasm
.focal adhesion
.cell-cell junction
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 25 1
2014-09-19protein level
5 22 1
2014-05-27protein level
5 22 1
2014-02-25protein level
5 15 1
2013-12-09protein level
5 12 1
2013-11-01protein level
5 12 1
2013-09-12protein level
5 12 1
2013-08-17protein level
5 12 1
2013-07-15protein level
5 12 1
2013-06-11protein level
5 12 1
2013-02-12protein level
5 6 5
2012-12-20protein level
5 8 5
2012-10-30protein level
5 7 5
2012-10-07protein level
5 7 1
2012-08-24protein level
5 7 1
2012-07-28protein level
5 7 1
2012-06-08protein level
5 15 1
2012-05-07protein level
5 13 1
2012-04-10protein level
2 11 1
2012-01-13protein level
1 10 1
2011-12-20protein level
1 10 1
2011-11-11protein level
1 10 1
2011-08-23protein level
1 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P48059-1
1 6 10 37225.7393
NX_P48059-2
1 6 10 38395.2682
NX_P48059-3
0 6 14 44360.2382
NX_P48059-4
1 6 10 37674.8785
NX_P48059-5
2 6 10 41542.9776
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-306928,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-306928,EBI-747644 ILK  
  .negative regulation of neural precursor cell proliferation
.positive regulation of canonical Wnt signaling pathway
.platelet aggregation
  + 37 more...
.protein kinase binding
.ATP binding
.signal transducer activity
.protein serine/threonine kinase activity
.protein complex
.dendritic shaft
.terminal bouton
  + 13 more...
3 EBI-306928,EBI-1057132 RSU1  
  .positive regulation of neural precursor cell proliferation
.positive regulation of GTPase activity
.cell junction assembly
  + 3 more...
.N/A .extracellular exosome
.focal adhesion
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
bladder200
blood73
bone41
bone marrow307
brain25
cervix20
connective tissue80
embryonic tissue112
esophagus198
eye9
heart67
intestine25
kidney66
liver29
lung44
lymph node111
mammary gland26
mouth105
muscle18
ovary59
pancreas28
pharynx24
placenta52
prostate42
salivary gland49
skin85
stomach62
testis2
thymus50
trachea19
umbilical cord145
uterus60
vascular77
Health State
TissuesTPM*
normal40
bladder carcinoma227
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma84
colorectal tumor17
esophageal tumor231
gastrointestinal tumor50
germ cell tumor53
glioma74
head and neck tumor52
kidney tumor58
leukemia127
liver tumor41
lung tumor19
lymphoma13
non-neoplasia124
ovarian tumor52
pancreatic tumor38
primitive neuroectodermal tumor of the CNS23
prostate cancer77
skin tumor119
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult41
embryoid body114
blastocyst130
neonate96
fetus43
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue40.8
adrenal gland54.7
appendix37.3
bone marrow21.6
cerebral cortex13.8
colon23.1
duodenum19.3
esophagus33.9
gallbladder41
heart muscle34.7
kidney21.7
liver13.7
lung34.9
lymph node42.9
ovary20.9
pancreas7.8
placenta29.6
prostate26
salivary gland17.4
skin14.1
small intestine21.3
spleen23.5
stomach27.6
testis24.3
thyroid gland31.9
urinary bladder46.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602567, gene) Lim and senescent cell antigen-like domains 1; LIMS1OMIM


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