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> Protein (NX_P48357)
Protein (NX_P48357)
Protein
Gene SymbolLEPR to neXtProt (NX_P48357)
DescriptionLeptin receptor
Chromosome1
Location1p31.3 (65886248 ~ 66107242) to Ensembl
Sequene Features : Isoforms 5, Variants 173, PTMs 31 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of hydrolase activity
.negative regulation of gluconeogenesis
.cholesterol metabolic process
  + 3 more...
.identical protein binding
.cytokine receptor activity
.transmembrane signaling receptor activity
.receptor complex
.integral component of membrane
.plasma membrane
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 173 31
2014-09-19protein level
5 124 31
2014-05-27protein level
5 124 31
2014-02-25protein level
5 123 31
2013-12-09protein level
5 106 31
2013-11-01protein level
5 100 31
2013-09-12protein level
5 100 31
2013-08-17protein level
5 100 31
2013-07-15protein level
5 69 31
2013-06-11protein level
5 69 31
2013-02-12protein level
5 22 142
2012-12-20protein level
5 21 142
2012-10-30protein level
5 25 142
2012-10-07protein level
5 25 30
2012-08-24protein level
5 24 30
2012-07-28protein level
5 24 30
2012-06-08protein level
5 30 30
2012-05-07protein level
5 26 29
2012-04-10protein level
5 26 29
2012-01-13protein level
5 17 29
2011-12-20protein level
5 17 29
2011-11-11protein level
5 17 29
2011-08-23protein level
5 17 29
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P48357-1
12 45 0 132407.6154
NX_P48357-2
0 46 0 102423.1986
NX_P48357-3
4 46 0 109321.6732
NX_P48357-4
1 46 0 103393.6906
NX_P48357-5
0 43 0 95978.6799
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7886448,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-518596,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
bladder33
blood40
bone27
bone marrow143
brain31
cervix41
connective tissue60
ear62
embryonic tissue65
eye47
heart100
intestine30
kidney71
larynx42
liver58
lung92
lymph22
lymph node55
mammary gland79
mouth15
muscle84
nerve128
ovary59
pancreas140
parathyroid242
pharynx98
pituitary gland121
placenta120
prostate42
salivary gland148
skin90
spleen18
stomach83
testis34
thymus12
thyroid64
trachea38
umbilical cord217
uterus103
vascular212
Health State
TissuesTPM*
normal79
adrenal tumor237
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma169
colorectal tumor17
gastrointestinal tumor75
germ cell tumor53
glioma93
head and neck tumor29
kidney tumor43
leukemia63
liver tumor72
lung tumor19
lymphoma41
non-neoplasia41
ovarian tumor65
pancreatic tumor76
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
skin tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult23
embryoid body28
blastocyst32
neonate32
fetus28
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.2
adrenal gland8.8
appendix4.4
bone marrow3.2
cerebral cortex3.5
colon6.9
duodenum3.8
esophagus11
gallbladder17.7
heart muscle6.5
kidney8
liver65
lung24
lymph node10.3
ovary27.1
pancreas1.5
placenta4.6
prostate10.2
salivary gland3
skin13.5
small intestine5.9
spleen3.2
stomach6.8
testis4.7
thyroid gland4.4
urinary bladder11.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(+601007, gene/phenotype) Leptin receptor; LEPROMIM


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