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> Protein (NX_P49023)
Protein (NX_P49023)
Protein
Gene SymbolPXN to neXtProt (NX_P49023)
DescriptionPaxillin
Chromosome12
Location12q24.23 (120648250 ~ 120703574) to Ensembl
Sequene Features : Isoforms 4, Variants 49, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 49 27
2014-09-19protein level
4 42 27
2014-05-27protein level
4 42 27
2014-02-25protein level
4 42 27
2013-12-09protein level
4 25 27
2013-11-01protein level
4 25 27
2013-09-12protein level
4 25 27
2013-08-17protein level
4 25 27
2013-07-15protein level
4 18 27
2013-06-11protein level
4 18 27
2013-02-12protein level
4 11 73
2012-12-20protein level
4 9 73
2012-10-30protein level
4 16 73
2012-10-07protein level
4 16 23
2012-08-24protein level
4 13 23
2012-07-28protein level
4 13 23
2012-06-08protein level
4 17 23
2012-05-07protein level
4 17 23
2012-04-10protein level
4 17 23
2012-01-13protein level
4 12 23
2011-12-20protein level
4 12 23
2011-11-11protein level
4 12 17
2011-08-23protein level
4 12 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49023-1
2 25 0 64463.6723
NX_P49023-2
0 25 0 60927.0835
NX_P49023-3
3 25 0 66169.6767
NX_P49023-4
1 19 0 46573.2339
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-702209,EBI-6082935 ITGB1  
  .negative regulation of anoikis
.positive regulation of establishment of protein localization to plasma membrane
.response to transforming growth factor beta
  + 57 more...
.collagen binding involved in cell-matrix adhesion
.cell adhesion molecule binding
.protein heterodimerization activity
  + 5 more...
.synaptic membrane
.invadopodium membrane
.extracellular exosome
  + 32 more...
2 EBI-702209,EBI-703044 ITGA4  
  .negative regulation of protein homodimerization activity
.T cell migration
.chorio-allantoic fusion
  + 18 more...
.cell adhesion molecule binding
.metal ion binding
.extracellular exosome
.integrin alpha4-beta7 complex
.membrane
  + 5 more...
3 EBI-702209,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
4 EBI-702209,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
5 EBI-702209,EBI-1380630 CSK  
  .cellular response to peptide hormone stimulus
.negative regulation of ERK1 and ERK2 cascade
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 26 more...
.identical protein binding
.protein C-terminus binding
.ATP binding
  + 3 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 4 more...
6 EBI-702209,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
7 EBI-702209,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
8 EBI-702209,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
9 EBI-702209,EBI-1046878 GIT2  
  .behavioral response to pain
.regulation of G-protein coupled receptor protein signaling pathway
.zinc ion binding
.GTPase activator activity
.focal adhesion
.nucleoplasm
10 EBI-702209,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites150
bladder200
blood114
bone167
bone marrow225
brain109
cervix103
connective tissue87
embryonic tissue108
esophagus99
eye119
heart145
intestine94
kidney147
larynx85
liver58
lung176
lymph node89
mammary gland92
mouth105
muscle65
ovary108
pancreas192
parathyroid97
placenta219
prostate205
salivary gland98
skin303
spleen74
stomach125
testis227
thymus225
thyroid21
tonsil293
trachea463
umbilical cord145
uterus206
vascular193
Health State
TissuesTPM*
normal112
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor107
cervical tumor144
chondrosarcoma181
colorectal tumor133
esophageal tumor115
gastrointestinal tumor143
germ cell tumor136
glioma130
head and neck tumor89
kidney tumor43
leukemia105
liver tumor83
lung tumor243
lymphoma41
non-neoplasia72
ovarian tumor118
pancreatic tumor333
primitive neuroectodermal tumor of the CNS86
prostate cancer240
retinoblastoma21
skin tumor319
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult133
embryoid body142
blastocyst179
neonate321
fetus80
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue61
adrenal gland28.4
appendix45.7
bone marrow60.7
cerebral cortex12.5
colon51.3
duodenum46.4
esophagus26
gallbladder45.9
heart muscle35.3
kidney40.2
liver11.2
lung62.5
lymph node29.7
ovary18.7
pancreas15.9
placenta66.8
prostate34.3
salivary gland23.2
skin28
small intestine52.8
spleen46.7
stomach40.1
testis30.4
thyroid gland41.5
urinary bladder47.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumLow
endometrium 1Medium
endometrium 2Low
epididymisHigh
esophagusLow
fallopian tubeHigh
gallbladderMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleHigh
skin 1Medium
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602505, gene) Paxillin; PXNOMIM


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