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> Protein (NX_P49247)
Protein (NX_P49247)
Protein
Gene SymbolRPIA to neXtProt (NX_P49247)
DescriptionRibose-5-phosphate isomerase
Chromosome2
Location2p11.2 (88991162 ~ 89050452) to Ensembl
Sequene Features : Isoforms 1, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.pentose-phosphate shunt, non-oxidative branch
.pentose-phosphate shunt
.carbohydrate metabolic process
.monosaccharide binding
.ribose-5-phosphate isomerase activity
.intracellular membrane-bounded organelle
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 31 4
2014-09-19protein level
1 29 4
2014-05-27protein level
1 29 4
2014-02-25protein level
1 28 2
2013-12-09protein level
1 22 2
2013-11-01protein level
1 22 2
2013-09-12protein level
1 22 2
2013-08-17protein level
1 22 2
2013-07-15protein level
1 15 2
2013-06-11protein level
1 15 2
2013-02-12protein level
1 4 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 5 0
2012-07-28protein level
1 5 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49247-1
19 0 0 33247.8819
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744831,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
2 EBI-744831,EBI-353343 PCMT1  
  .protein repair
.protein methylation
.protein-L-isoaspartate (D-aspartate) O-methyltransferase activity .extracellular exosome
.vesicle
.endoplasmic reticulum
.cytoplasm
3 EBI-744831,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
4 EBI-744831,EBI-10250303 CENPP  
  .CENP-A containing nucleosome assembly
.small GTPase mediated signal transduction
.nucleosome assembly
.mitotic cell cycle
.N/A .cytosol
.nucleoplasm
.chromosome, centromeric region
5 EBI-744831,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
6 EBI-744831,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
7 EBI-744831,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
8 EBI-744831,EBI-751555 RNF208  
  .protein autoubiquitination .zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleoplasm
9 EBI-744831,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder33
blood65
bone27
bone marrow20
brain10
cervix144
connective tissue20
ear124
embryonic tissue61
eye9
intestine68
kidney9
liver14
lung44
lymph67
lymph node100
mammary gland33
ovary49
pancreas14
placenta91
prostate21
skin23
spleen18
stomach20
testis27
thyroid21
uterus17
Health State
TissuesTPM*
normal33
adrenal tumor158
breast (mammary gland) tumor21
chondrosarcoma60
colorectal tumor53
gastrointestinal tumor33
germ cell tumor34
head and neck tumor7
kidney tumor14
leukemia95
liver tumor10
lymphoma110
non-neoplasia10
ovarian tumor26
pancreatic tumor28
prostate cancer28
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult41
embryoid body28
blastocyst16
fetus53
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.7
adrenal gland10
appendix18.7
bone marrow48.4
cerebral cortex3.4
colon20.2
duodenum17.8
esophagus16.2
gallbladder12.1
heart muscle8.6
kidney7.2
liver3.6
lung10.8
lymph node24.9
ovary11.9
pancreas6.5
placenta28.1
prostate8.1
salivary gland7.4
skin6.3
small intestine16.1
spleen17.1
stomach15.5
testis9.5
thyroid gland8.6
urinary bladder13.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*180430, gene) Ribose 5-phosphate isomerase a; RPIAOMIM
2(#608611, phenotype) Ribose 5-phosphate isomerase deficiencyOMIM


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