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> Protein (NX_P49257)
Protein (NX_P49257)
Protein
Gene SymbolLMAN1 to neXtProt (NX_P49257)
DescriptionProtein ERGIC-53
Chromosome18
Location18q21.32 (56995055 ~ 57027194) to Ensembl
Sequene Features : Isoforms 1, Variants 63, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.post-translational protein modification
.protein N-linked glycosylation via asparagine
  + 7 more...
.unfolded protein binding
.metal ion binding
.mannose binding
.extracellular exosome
.host cell perinuclear region of cytoplasm
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 63 10
2014-09-19protein level
1 52 10
2014-05-27protein level
1 52 10
2014-02-25protein level
1 52 10
2013-12-09protein level
1 43 10
2013-11-01protein level
1 42 8
2013-09-12protein level
1 42 8
2013-08-17protein level
1 42 8
2013-07-15protein level
1 28 3
2013-06-11protein level
1 28 3
2013-02-12protein level
1 15 3
2012-12-20protein level
1 15 3
2012-10-30protein level
1 17 3
2012-10-07protein level
1 17 3
2012-08-24protein level
1 14 3
2012-07-28protein level
1 14 3
2012-06-08protein level
1 15 3
2012-05-07protein level
1 15 3
2012-04-10protein level
1 15 3
2012-01-13protein level
1 13 3
2011-12-20protein level
1 13 3
2011-11-11protein level
1 13 3
2011-08-23protein level
1 13 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49257-1
21 0 0 57512.8177
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1057738,EBI-1044848 SURF4  
  .positive regulation of organelle organization
.Golgi organization
.N/A .endoplasmic reticulum-Golgi intermediate compartment membrane
.integral component of membrane
.endoplasmic reticulum-Golgi intermediate compartment
  + 2 more...
2 EBI-1057738,EBI-541644 ERP44  
  .cell redox homeostasis
.response to endoplasmic reticulum stress
.glycoprotein metabolic process
  + 2 more...
.protein disulfide isomerase activity .extracellular exosome
.cell surface
.endoplasmic reticulum-Golgi intermediate compartment
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland151
ascites50
bladder133
blood32
bone125
bone marrow184
brain45
cervix41
connective tissue107
ear248
embryonic tissue155
esophagus396
eye134
heart89
intestine73
kidney132
liver160
lung62
lymph45
lymph node89
mammary gland79
mouth75
muscle65
ovary147
pancreas60
parathyroid242
pharynx24
pituitary gland181
placenta169
prostate63
skin75
spleen74
stomach62
testis66
thymus112
thyroid171
trachea289
umbilical cord72
uterus172
vascular193
Health State
TissuesTPM*
normal100
adrenal tumor316
bladder carcinoma284
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma156
colorectal tumor35
esophageal tumor463
gastrointestinal tumor109
germ cell tumor68
glioma55
head and neck tumor89
kidney tumor101
leukemia84
liver tumor124
lung tumor58
lymphoma55
non-neoplasia155
ovarian tumor157
pancreatic tumor47
primitive neuroectodermal tumor of the CNS78
prostate cancer57
retinoblastoma129
skin tumor55
soft tissue/muscle tissue tumor63
uterine tumor210
Developmental Stage
TissuesTPM*
adult108
embryoid body185
blastocyst146
neonate96
fetus73
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.5
adrenal gland41.3
appendix39.4
bone marrow16.2
cerebral cortex15.8
colon33.2
duodenum40.4
esophagus29.2
gallbladder32.5
heart muscle29.8
kidney49.3
liver78
lung32
lymph node27.7
ovary38.7
pancreas23
placenta45
prostate52.9
salivary gland45.7
skin17.8
small intestine43.1
spleen24.2
stomach46.6
testis23.9
thyroid gland79.6
urinary bladder40.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumLow
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#227300, phenotype) Factor v and factor viii, combined deficiency of, 1; F5F8D1OMIM
2(*601567, gene) Lectin, mannose-binding, 1; LMAN1OMIM


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