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> Protein (NX_P49366)
Protein (NX_P49366)
Protein
Gene SymbolDHPS to neXtProt (NX_P49366)
DescriptionDeoxyhypusine synthase
Chromosome19
Location19p13.2 (12786531 ~ 12792716) to Ensembl
Sequene Features : Isoforms 3, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homotetramerization
.deoxyhypusine biosynthetic process from spermidine
.cellular protein metabolic process
  + 6 more...
.deoxyhypusine synthase activity .cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 46 6
2014-09-19protein level
3 38 6
2014-05-27protein level
3 38 6
2014-02-25protein level
3 37 6
2013-12-09protein level
3 26 6
2013-11-01protein level
3 26 5
2013-09-12protein level
3 26 5
2013-08-17protein level
3 26 5
2013-07-15protein level
2 11 2
2013-06-11protein level
2 11 2
2013-02-12protein level
2 7 7
2012-12-20protein level
2 8 6
2012-10-30protein level
2 9 6
2012-10-07protein level
2 9 3
2012-08-24protein level
2 10 3
2012-07-28protein level
2 10 3
2012-06-08protein level
2 34 3
2012-05-07protein level
2 33 3
2012-04-10protein level
2 33 3
2012-01-13protein level
2 30 3
2011-12-20protein level
2 30 3
2011-11-11protein level
2 30 3
2011-08-23protein level
2 30 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49366-1
0 19 0 40944.4711
NX_P49366-2
1 14 0 35892.8446
NX_P49366-3
2 15 0 36559.1626
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741925,EBI-10179046 RAB27B  
  .multivesicular body sorting pathway
.positive regulation of exocytosis
.Rab protein signal transduction
  + 5 more...
.myosin V binding
.protein domain specific binding
.GDP binding
  + 2 more...
.extracellular exosome
.zymogen granule membrane
.melanosome
  + 5 more...
2 EBI-741925,EBI-73995 MAPK3  
  .negative regulation of apolipoprotein binding
.regulation of early endosome to late endosome transport
.regulation of cellular response to heat
  + 62 more...
.phosphatase binding
.ATP binding
.MAP kinase activity
.extracellular exosome
.pseudopodium
.microtubule cytoskeleton
  + 11 more...
3 EBI-741925,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
4 EBI-741925,EBI-10213071 ZNF138  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
5 EBI-741925,EBI-373150 EIF5A  
  .positive regulation of translational termination
.positive regulation of translational elongation
.cellular protein metabolic process
  + 8 more...
.protein N-terminus binding
.poly(A) RNA binding
.ribosome binding
  + 3 more...
.extracellular exosome
.membrane
.cytosol
  + 5 more...
6 EBI-741925,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
7 EBI-741925,EBI-740486 NUDT18  
  .nucleobase-containing small molecule metabolic process
.GDP catabolic process
.dGDP catabolic process
  + 3 more...
.8-hydroxy-dADP phosphatase activity
.8-oxo-GDP phosphatase activity
.8-oxo-dGDP phosphatase activity
.magnesium ion binding
.cytosol
8 EBI-741925,EBI-10256546 VASH1  
  .regulation of cellular senescence
.negative regulation of lymphangiogenesis
.negative regulation of blood vessel endothelial cell migration
  + 6 more...
.N/A .apical part of cell
.endoplasmic reticulum
.cytoplasm
.extracellular space
9 EBI-741925,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
10 EBI-741925,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
11 EBI-741925,EBI-748028 EIF5A2  
  .mRNA transport
.positive regulation of translational termination
.positive regulation of translational elongation
  + 8 more...
.ribosome binding
.translation elongation factor activity
.cytosol
.endoplasmic reticulum membrane
.nuclear pore
12 EBI-741925,EBI-1267176 PTPRH  
  .peptidyl-tyrosine dephosphorylation
.apoptotic process
.protein dephosphorylation
.transmembrane receptor protein tyrosine phosphatase activity .integral component of plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland212
ascites75
bladder100
blood114
bone153
bone marrow82
brain111
cervix20
connective tissue67
ear62
embryonic tissue51
eye167
heart11
intestine56
kidney56
liver38
lung113
lymph135
lymph node22
mammary gland59
mouth15
muscle103
nerve64
ovary167
pancreas70
pharynx24
pituitary gland121
placenta63
prostate58
salivary gland49
skin28
spleen262
stomach73
testis57
thymus338
thyroid64
tonsil58
uterus116
vascular19
Health State
TissuesTPM*
normal78
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma144
colorectal tumor71
gastrointestinal tumor33
germ cell tumor41
glioma149
head and neck tumor29
kidney tumor43
leukemia127
liver tumor41
lung tumor272
lymphoma193
non-neoplasia31
ovarian tumor183
pancreatic tumor76
primitive neuroectodermal tumor of the CNS157
prostate cancer28
retinoblastoma258
skin tumor39
soft tissue/muscle tissue tumor23
uterine tumor88
Developmental Stage
TissuesTPM*
adult72
embryoid body100
blastocyst32
fetus44
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.3
adrenal gland47.6
appendix46.4
bone marrow30.9
cerebral cortex44.3
colon36.2
duodenum49.9
esophagus29.9
gallbladder38.6
heart muscle36.5
kidney37.6
liver25.3
lung43.2
lymph node63
ovary60.8
pancreas30.8
placenta37.9
prostate48.9
salivary gland39
skin52.4
small intestine39.9
spleen58.3
stomach39
testis29
thyroid gland40.5
urinary bladder41
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungLow
lymph nodeLow
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasLow
parathyroid glandLow
placentaLow
prostateLow
rectumHigh
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600944, gene) Deoxyhypusine synthase; DHPSOMIM


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2014-2019 (C) Yonsei Proteome Research Center