Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P49407)
Protein (NX_P49407)
Protein
Gene SymbolARRB1 to neXtProt (NX_P49407)
DescriptionBeta-arrestin-1
Chromosome11
Location11q13.4 (74975226 ~ 75062873) to Ensembl
Sequene Features : Isoforms 2, Variants 47, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 47 3
2014-09-19protein level
2 33 3
2014-05-27protein level
2 33 3
2014-02-25protein level
2 33 3
2013-12-09protein level
2 24 3
2013-11-01protein level
2 22 3
2013-09-12protein level
2 22 3
2013-08-17protein level
2 22 3
2013-07-15protein level
2 13 3
2013-06-11protein level
2 13 3
2013-02-12protein level
2 8 6
2012-12-20protein level
2 6 6
2012-10-30protein level
2 10 6
2012-10-07protein level
2 10 3
2012-08-24protein level
2 6 3
2012-07-28protein level
2 6 3
2012-06-08protein level
2 17 3
2012-05-07protein level
2 17 3
2012-04-10protein level
2 17 3
2012-01-13protein level
2 19 3
2011-12-20protein level
2 19 3
2011-11-11protein level
2 19 4
2011-08-23protein level
2 19 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49407-1
1 16 1 47036.1533
NX_P49407-2
1 16 1 46279.7537
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743313,EBI-1047039 PPM1B  
  .negative regulation of defense response to virus
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of NF-kappaB import into nucleus
  + 5 more...
.manganese ion binding
.protein serine/threonine phosphatase activity
.magnesium ion binding
.membrane
.cytosol
2 EBI-743313,EBI-1051583 ZRANB2  
  .RNA splicing
.mRNA processing
.regulation of transcription, DNA-templated
.poly(A) RNA binding
.zinc ion binding
.RNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
3 EBI-743313,EBI-351506 GSN  
  .positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.amyloid fibril formation
.positive regulation of protein processing in phagocytic vesicle
  + 32 more...
.myosin II binding
.protein domain specific binding
.calcium ion binding
.actin binding
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
4 EBI-743313,EBI-1055001 S100A9  
  .positive regulation of intrinsic apoptotic signaling pathway
.neutrophil aggregation
.regulation of cytoskeleton organization
  + 24 more...
.RAGE receptor binding
.arachidonic acid binding
.Toll-like receptor 4 binding
  + 5 more...
.extracellular exosome
.plasma membrane
.cytoskeleton
  + 4 more...
5 EBI-743313,EBI-351896 HSPA8  
  .negative regulation of fibril organization
.regulation of cellular response to heat
.clathrin coat disassembly
  + 18 more...
.C3HC4-type RING finger domain binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.blood microparticle
.extracellular exosome
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
  + 13 more...
6 EBI-743313,EBI-353408 PKM  
  .canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
7 EBI-743313,EBI-346967 NCL  
  .positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.angiogenesis
.poly(A) RNA binding
.identical protein binding
.telomeric DNA binding
  + 3 more...
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 5 more...
8 EBI-743313,EBI-1165705 CD247  
  .T cell receptor signaling pathway
.regulation of immune response
.regulation of defense response to virus by virus
  + 4 more...
.protein homodimerization activity
.identical protein binding
.transmembrane signaling receptor activity
.alpha-beta T cell receptor complex
.T cell receptor complex
.integral component of membrane
  + 2 more...
9 EBI-743313,EBI-765538 YY1  
  .chromosome organization
.camera-type eye morphogenesis
.response to prostaglandin F
  + 12 more...
.SMAD binding
.transcription regulatory region DNA binding
.zinc ion binding
  + 8 more...
.PcG protein complex
.Ino80 complex
.nuclear matrix
  + 2 more...
10 EBI-743313,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
11 EBI-743313,EBI-989143 PPM1A  
  .positive regulation of transcription, DNA-templated
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 16 more...
.R-SMAD binding
.calmodulin-dependent protein phosphatase activity
.manganese ion binding
  + 3 more...
.neuron projection
.membrane
.voltage-gated calcium channel complex
  + 3 more...
12 EBI-743313,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
13 EBI-743313,EBI-3909604 GNAQ  
  .phospholipase C-activating dopamine receptor signaling pathway
.protein stabilization
.developmental pigmentation
  + 18 more...
.metal ion binding
.type 2A serotonin receptor binding
.G-protein beta/gamma-subunit complex binding
  + 4 more...
.extracellular exosome
.nuclear membrane
.plasma membrane
  + 3 more...
14 EBI-743313,EBI-713543 MAPK10  
  .stress-activated MAPK cascade
.regulation of sequence-specific DNA binding transcription factor activity
.rhythmic process
  + 21 more...
.ATP binding
.MAP kinase kinase activity
.JUN kinase activity
.plasma membrane
.cytosol
.mitochondrion
  + 2 more...
15 EBI-743313,EBI-397435 CALM2  
  .regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
16 EBI-743313,EBI-396105 TCOF1  
  .transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.skeletal system development
.poly(A) RNA binding
.transporter activity
.cytoplasm
.nucleolus
.nucleus
17 EBI-743313,EBI-395940 PRPF4B  
  .RNA splicing
.protein phosphorylation
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.catalytic step 2 spliceosome
.chromosome
.nucleoplasm
18 EBI-743313,EBI-744239 GNMT  
  .protein homotetramerization
.S-adenosylmethionine metabolic process
.one-carbon metabolic process
  + 4 more...
.glycine N-methyltransferase activity
.glycine binding
.folic acid binding
.cytoplasm
19 EBI-743313,EBI-396155 NOLC1  
  .mitotic nuclear division
.cell cycle
.nucleolus organization
.rRNA processing
.poly(A) RNA binding
.GTP binding
.ATP binding
.Cajal body
.cytoplasm
.nucleolus
.nucleoplasm
20 EBI-743313,EBI-458376 STK38  
  .negative regulation of MAP kinase activity
.intracellular signal transduction
.protein phosphorylation
.cellular protein modification process
.mitogen-activated protein kinase kinase kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.MLL5-L complex
.cytoplasm
.nucleus
21 EBI-743313,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
22 EBI-743313,EBI-4400880 GNAS  
  .genetic imprinting
.platelet aggregation
.hair follicle placode formation
  + 18 more...
.corticotropin-releasing hormone receptor 1 binding
.metal ion binding
.ionotropic glutamate receptor binding
  + 8 more...
.extracellular exosome
.dendrite
.membrane
  + 2 more...
23 EBI-743313,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites50
bladder33
blood73
bone13
bone marrow82
brain123
connective tissue33
ear62
embryonic tissue18
esophagus99
eye71
heart55
intestine125
kidney33
liver9
lung92
mammary gland99
muscle37
nerve64
ovary19
pancreas37
parathyroid48
pharynx49
placenta109
prostate100
skin33
spleen112
stomach31
testis9
thymus37
trachea57
umbilical cord290
uterus38
vascular19
Health State
TissuesTPM*
normal85
bladder carcinoma56
breast (mammary gland) tumor53
chondrosarcoma48
colorectal tumor97
esophageal tumor57
gastrointestinal tumor33
germ cell tumor53
glioma37
head and neck tumor14
kidney tumor72
leukemia31
lung tumor58
non-neoplasia93
ovarian tumor39
pancreatic tumor57
primitive neuroectodermal tumor of the CNS125
prostate cancer28
retinoblastoma64
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult68
embryoid body14
blastocyst48
neonate160
fetus93
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.4
adrenal gland6.7
appendix20.3
bone marrow9.8
cerebral cortex33.5
colon26.8
duodenum18.1
esophagus17
gallbladder12.9
heart muscle13.6
kidney12.8
liver5.8
lung54.1
lymph node15
ovary15.3
pancreas12.1
placenta24.9
prostate15.6
salivary gland9.8
skin13.9
small intestine22.9
spleen38.2
stomach20.5
testis5.5
thyroid gland6.5
urinary bladder19.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*107940, gene) Arrestin, beta, 1; ARRB1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center