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> Protein (NX_P49590)
Protein (NX_P49590)
Protein
Gene SymbolHARS2 to neXtProt (NX_P49590)
DescriptionProbable histidine--tRNA ligase, mitochondrial
Chromosome5
Location5q31.3 (140071011 ~ 140078889) to Ensembl
Sequene Features : Isoforms 2, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.histidyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.translation
.poly(A) RNA binding
.ATP binding
.histidine-tRNA ligase activity
.mitochondrial matrix
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 49 3
2014-09-19protein level
2 40 3
2014-05-27protein level
1 40 5
2014-02-25protein level
1 39 5
2013-12-09protein level
1 31 5
2013-11-01protein level
1 30 3
2013-09-12protein level
1 30 3
2013-08-17protein level
1 30 3
2013-07-15protein level
1 20 2
2013-06-11protein level
1 20 2
2013-02-12protein level
1 8 2
2012-12-20protein level
1 7 2
2012-10-30protein level
1 7 2
2012-10-07protein level
1 7 2
2012-08-24protein level
1 7 2
2012-07-28protein level
1 7 2
2012-06-08protein level
1 7 2
2012-05-07protein level
1 4 2
2012-04-10protein level
1 4 2
2012-01-13protein level
1 3 2
2011-12-20protein level
1 3 2
2011-11-11protein level
1 3 2
2011-08-23protein level
1 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49590-1
2 19 7 56851.499
NX_P49590-2
0 19 7 54079.9375
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3909030,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites100
bladder133
blood65
bone41
brain75
cervix61
connective tissue80
embryonic tissue46
esophagus49
eye67
heart33
intestine112
kidney71
larynx42
liver29
lung56
lymph293
lymph node11
mammary gland132
muscle28
nerve64
ovary39
pancreas14
pharynx122
placenta56
prostate31
salivary gland98
skin132
spleen74
stomach20
testis32
thymus100
trachea38
uterus99
vascular38
Health State
TissuesTPM*
normal60
breast (mammary gland) tumor107
cervical tumor57
chondrosarcoma60
colorectal tumor142
esophageal tumor57
gastrointestinal tumor67
germ cell tumor56
glioma83
head and neck tumor22
kidney tumor87
leukemia31
liver tumor52
lung tumor87
lymphoma221
non-neoplasia41
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS70
retinoblastoma86
skin tumor183
soft tissue/muscle tissue tumor55
uterine tumor77
Developmental Stage
TissuesTPM*
adult49
embryoid body57
blastocyst48
neonate96
fetus57
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.9
adrenal gland18.4
appendix17.8
bone marrow11.2
cerebral cortex12.3
colon20.9
duodenum18.8
esophagus14.7
gallbladder14.6
heart muscle19.3
kidney18.2
liver7.5
lung17.4
lymph node20.3
ovary19.1
pancreas5.5
placenta16.1
prostate18.3
salivary gland10
skin19
small intestine16.7
spleen20
stomach16.8
testis16.1
thyroid gland14.4
urinary bladder16.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600783, gene) Histidyl-trna synthetase 2; HARS2OMIM
2(#614926, phenotype) Perrault syndrome 2; PRLTS2OMIM


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