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> Protein (NX_P49639)
Protein (NX_P49639)
Protein
Gene SymbolHOXA1 to neXtProt (NX_P49639)
DescriptionHomeobox protein Hox-A1
Chromosome7
Location7p15.2 (27132612 ~ 27135615) to Ensembl
Sequene Features : Isoforms 3, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 67 0
2014-09-19protein level
3 51 0
2014-05-27protein level
3 50 0
2014-02-25protein level
3 48 0
2013-12-09protein level
3 44 0
2013-11-01protein level
3 43 0
2013-09-12protein level
3 43 0
2013-08-17protein level
3 43 0
2013-07-15protein level
3 26 0
2013-06-11protein level
3 26 0
2013-02-12protein level
3 11 0
2012-12-20protein level
3 11 0
2012-10-30protein level
3 12 0
2012-10-07protein level
3 12 0
2012-08-24protein level
3 6 0
2012-07-28protein level
3 6 0
2012-06-08protein level
3 2 0
2012-05-07protein level
3 2 0
2012-04-10protein level
3 2 0
2012-01-13protein level
3 2 0
2011-12-20protein level
3 5 0
2011-11-11protein level
3 5 0
2011-08-23protein level
3 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49639-1
4 4 0 36618.3214
NX_P49639-2
2 2 0 14806.7323
NX_P49639-3
1 4 0 24473.103
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740785,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-740785,EBI-349968 SUV39H1  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
3 EBI-740785,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
4 EBI-740785,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
5 EBI-740785,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
6 EBI-740785,EBI-977302 PRNP  
  .regulation of potassium ion transmembrane transport
.cellular response to copper ion
.negative regulation of calcineurin-NFAT signaling cascade
  + 17 more...
.identical protein binding
.tubulin binding
.microtubule binding
.copper ion binding
.extracellular exosome
.membrane raft
.anchored component of membrane
  + 7 more...
7 EBI-740785,EBI-1754109 GP9  
  .platelet activation
.blood coagulation, intrinsic pathway
.blood coagulation
.cell adhesion
.N/A .integral component of plasma membrane
.plasma membrane
8 EBI-740785,EBI-3909284 GATA1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of transcription regulatory region DNA binding
.cellular response to thyroid hormone stimulus
  + 26 more...
.C2H2 zinc finger domain binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 12 more...
.transcriptional repressor complex
.transcription factor complex
.nucleoplasm
.nucleus
9 EBI-740785,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
10 EBI-740785,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
11 EBI-740785,EBI-348489 PBX2  
  .positive regulation of transcription from RNA polymerase II promoter
.embryonic limb morphogenesis
.proximal/distal pattern formation
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.transcription factor complex
.nucleus
12 EBI-740785,EBI-10210845 KRTAP12-1  
  .N/A .N/A .keratin filament
13 EBI-740785,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
14 EBI-740785,EBI-10176396 KRTAP12-4  
  .N/A .N/A .keratin filament
15 EBI-740785,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
16 EBI-740785,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
17 EBI-740785,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
18 EBI-740785,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
19 EBI-740785,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
20 EBI-740785,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
21 EBI-740785,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
22 EBI-740785,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
23 EBI-740785,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
24 EBI-740785,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
25 EBI-740785,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
26 EBI-740785,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
27 EBI-740785,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
28 EBI-740785,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
29 EBI-740785,EBI-10261452 TBC1D10C  
  .negative regulation of ERK1 and ERK2 cascade
.negative regulation of NFAT protein import into nucleus
.negative regulation of B cell activation
.retrograde transport, endosome to Golgi
.GTPase activator activity .filopodium membrane
.membrane
.plasma membrane
30 EBI-740785,EBI-5235829 TRIM42  
  .N/A .zinc ion binding .intracellular
31 EBI-740785,EBI-2514973 N4BP2L2  
  .negative regulation of hematopoietic stem cell differentiation
.positive regulation of hematopoietic stem cell proliferation
.negative regulation of transcription from RNA polymerase II promoter
.enzyme binding
.RNA polymerase II transcription corepressor activity
.extracellular exosome
.transcriptional repressor complex
.nucleus
32 EBI-740785,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
33 EBI-740785,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
34 EBI-740785,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
35 EBI-740785,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
36 EBI-740785,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
37 EBI-740785,EBI-10302547 KRTAP4-7  
  .hair cycle
.aging
.N/A .keratin filament
38 EBI-740785,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
39 EBI-740785,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
40 EBI-740785,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
41 EBI-740785,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
42 EBI-740785,EBI-10186621 ALG13  
  .cellular protein metabolic process
.post-translational protein modification
.lipid glycosylation
  + 2 more...
.poly(A) RNA binding
.carbohydrate binding
.cysteine-type peptidase activity
.N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
.endoplasmic reticulum membrane
43 EBI-740785,EBI-3918154 RGS17  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.GTPase activator activity .plasma membrane
.cytoplasm
.nucleus
44 EBI-740785,EBI-3957707 LGALS13  
  .positive regulation of T cell apoptotic process
.apoptotic process
.phospholipid metabolic process
.carbohydrate binding
.lysophospholipase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood16
bone13
brain1
embryonic tissue14
kidney9
skin9
testis78
trachea19
uterus4
Health State
TissuesTPM*
normal3
bladder carcinoma56
gastrointestinal tumor8
germ cell tumor148
glioma9
kidney tumor14
skin tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult19
blastocyst48
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
colon1.1
esophagus1.8
lymph node1.3
ovary1.7
skin2.1
spleen1.1
urinary bladder8.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*142955, gene) Homeobox a1; HOXA1OMIM
2(#601536, phenotype) Athabaskan brainstem dysgenesis syndrome; ABDSOMIM


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2014-2019 (C) Yonsei Proteome Research Center