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> Protein (NX_P49760)
Protein (NX_P49760)
Protein
Gene SymbolCLK2 to neXtProt (NX_P49760)
DescriptionDual specificity protein kinase CLK2
Chromosome1
Location1q22 (155232659 ~ 155248282) to Ensembl
Sequene Features : Isoforms 3, Variants 90, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 90 7
2014-09-19protein level
3 61 7
2014-05-27protein level
3 61 7
2014-02-25protein level
3 61 7
2013-12-09protein level
3 46 7
2013-11-01protein level
3 43 7
2013-09-12protein level
3 43 7
2013-08-17protein level
3 43 7
2013-07-15protein level
3 34 7
2013-06-11protein level
3 34 7
2013-02-12protein level
3 13 37
2012-12-20protein level
3 14 37
2012-10-30protein level
3 18 37
2012-10-07protein level
3 18 14
2012-08-24protein level
3 12 14
2012-07-28protein level
3 12 14
2012-06-08protein level
3 12 14
2012-05-07protein level
3 12 14
2012-04-10protein level
3 12 14
2012-01-13protein level
3 3 14
2011-12-20protein level
3 3 14
2011-11-11protein level
3 3 15
2011-08-23protein level
3 3 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49760-1
1 16 1 60052.8104
NX_P49760-2
0 2 0 17558.5716
NX_P49760-3
0 16 1 59924.7522
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-750020,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-750020,EBI-744493 ZNF263  
  .negative regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-750020,EBI-746999 KLHL2  
  .protein ubiquitination .actin binding .Cul3-RING ubiquitin ligase complex
.lamellipodium
.actin cytoskeleton
  + 3 more...
4 EBI-750020,EBI-1049228 SNRNP70  
  .positive regulation of mRNA splicing, via spliceosome
.regulation of RNA splicing
.gene expression
  + 3 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.nuclear speck
.U1 snRNP
.spliceosomal complex
  + 2 more...
5 EBI-750020,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
6 EBI-750020,EBI-2859983 ECE1  
  .pharyngeal system development
.ear development
.embryonic digit morphogenesis
  + 11 more...
.metal ion binding
.protein homodimerization activity
.peptide hormone binding
  + 2 more...
.extracellular exosome
.perinuclear region of cytoplasm
.Weibel-Palade body
  + 9 more...
7 EBI-750020,EBI-745579 CLK3  
  .protein autophosphorylation
.regulation of RNA splicing
.protein phosphorylation
.poly(A) RNA binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.intermediate filament cytoskeleton
.nuclear speck
.membrane
  + 3 more...
8 EBI-750020,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
9 EBI-750020,EBI-10176676 U2AF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.metal ion binding
.poly(A) RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nuclear speck
.Cajal body
  + 2 more...
10 EBI-750020,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
11 EBI-750020,EBI-6657923 ZRSR2  
  .RNA splicing
.mRNA splicing, via spliceosome
.spliceosomal complex assembly
.metal ion binding
.pre-mRNA 3'-splice site binding
.nucleotide binding
.U12-type spliceosomal complex
12 EBI-750020,EBI-10211248 ZNF394  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
13 EBI-750020,EBI-1055880 SRRM1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.DNA binding
.catalytic step 2 spliceosome
.nuclear speck
.nuclear matrix
  + 3 more...
14 EBI-750020,EBI-746909 CPSF7  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
15 EBI-750020,EBI-715374 PRPF38A  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .precatalytic spliceosome
.nuclear membrane
.nucleus
16 EBI-750020,EBI-749336 SNIP1  
  .positive regulation of protein targeting to mitochondrion
.production of miRNAs involved in gene silencing by miRNA
.I-kappaB kinase/NF-kappaB signaling
.regulation of transcription, DNA-templated
.poly(A) RNA binding .cytoplasm
.nucleoplasm
17 EBI-750020,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
18 EBI-750020,EBI-8643207 ZNF398  
  .positive regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
19 EBI-750020,EBI-751409 ZNF473  
  .mRNA 3'-end processing
.gene expression
.histone mRNA metabolic process
  + 4 more...
.metal ion binding
.DNA binding
.Cajal body
.nucleoplasm
20 EBI-750020,EBI-2849854 YTHDC1  
  .mRNA splice site selection .N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.RNA binding
.nuclear body
.nucleus
21 EBI-750020,EBI-745604 RSRP1  
  .N/A .N/A .N/A
22 EBI-750020,EBI-721368 MRPL4  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.cytosolic ribosome
.mitochondrial inner membrane
23 EBI-750020,EBI-10198848 LUZP4  
  .N/A .N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites25
bladder33
blood98
bone97
brain32
cervix103
connective tissue40
embryonic tissue108
esophagus49
eye47
heart55
intestine25
kidney52
larynx85
liver48
lung47
lymph45
lymph node44
mammary gland52
mouth105
muscle47
ovary167
pancreas46
parathyroid48
pharynx24
placenta31
prostate47
skin18
spleen18
stomach62
testis45
thymus62
thyroid85
uterus73
vascular19
Health State
TissuesTPM*
normal44
adrenal tumor79
breast (mammary gland) tumor53
chondrosarcoma96
colorectal tumor26
esophageal tumor57
gastrointestinal tumor50
germ cell tumor45
glioma46
head and neck tumor89
kidney tumor72
leukemia95
liver tumor62
lung tumor68
lymphoma27
non-neoplasia72
ovarian tumor170
pancreatic tumor57
primitive neuroectodermal tumor of the CNS47
prostate cancer19
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor39
uterine tumor99
Developmental Stage
TissuesTPM*
adult59
embryoid body85
blastocyst113
neonate32
fetus46
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.7
adrenal gland28.7
appendix43.7
bone marrow18.4
cerebral cortex13.4
colon18.7
duodenum33.5
esophagus21.3
gallbladder25.5
heart muscle14.8
kidney19
liver9.8
lung30.2
lymph node48.1
ovary36.6
pancreas14.1
placenta30.3
prostate29.9
salivary gland25.7
skin34.6
small intestine31.1
spleen49.4
stomach29.6
testis20
thyroid gland28.9
urinary bladder27.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602989, gene) Cdc-like kinase 2; CLK2OMIM


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