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> Protein (NX_P49761)
Protein (NX_P49761)
Protein
Gene SymbolCLK3 to neXtProt (NX_P49761)
DescriptionDual specificity protein kinase CLK3
Chromosome15
Location15q24.1 (74890841 ~ 74932057) to Ensembl
Sequene Features : Isoforms 4, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein autophosphorylation
.regulation of RNA splicing
.protein phosphorylation
.poly(A) RNA binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.intermediate filament cytoskeleton
.nuclear speck
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 66 7
2014-09-19protein level
4 44 7
2014-05-27protein level
4 41 7
2014-02-25protein level
4 41 7
2013-12-09protein level
4 37 7
2013-11-01protein level
4 37 7
2013-09-12protein level
4 37 7
2013-08-17protein level
4 37 7
2013-07-15protein level
4 23 6
2013-06-11protein level
4 23 6
2013-02-12protein level
4 12 31
2012-12-20protein level
4 11 31
2012-10-30protein level
4 13 31
2012-10-07protein level
4 13 8
2012-08-24protein level
4 12 8
2012-07-28protein level
4 12 8
2012-06-08protein level
4 13 8
2012-05-07protein level
4 9 8
2012-04-10protein level
4 9 8
2012-01-13protein level
4 6 8
2011-12-20protein level
4 6 8
2011-11-11protein level
4 6 8
2011-08-23protein level
4 6 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49761-1
0 19 0 58551.2026
NX_P49761-2
2 2 0 18959.4404
NX_P49761-3
1 17 0 56170.9774
NX_P49761-4
7 19 0 73468.8595
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745579,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-745579,EBI-744493 ZNF263  
  .negative regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-745579,EBI-349968 SUV39H1  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
4 EBI-745579,EBI-1248457 HOXB7  
  .positive regulation of branching involved in ureteric bud morphogenesis
.embryonic skeletal system morphogenesis
.myeloid cell differentiation
  + 4 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-745579,EBI-8638511 RBMY1A1  
  .RNA splicing
.mRNA processing
.regulation of alternative mRNA splicing, via spliceosome
.mRNA binding
.nucleotide binding
.nucleus
6 EBI-745579,EBI-741308 HOXB6  
  .embryonic skeletal system morphogenesis
.erythrocyte homeostasis
.anterior/posterior pattern specification
.transcription, DNA-templated
.poly(A) RNA binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleus
7 EBI-745579,EBI-10211452 OAS2  
  .type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
.defense response to virus
  + 7 more...
.metal ion binding
.zinc ion binding
.ATP binding
  + 2 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 5 more...
8 EBI-745579,EBI-743526 RBMX  
  .cellular response to interleukin-1
.protein homooligomerization
.positive regulation of mRNA splicing, via spliceosome
  + 10 more...
.poly(A) RNA binding
.mRNA binding
.single-stranded RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.supraspliceosomal complex
  + 6 more...
9 EBI-745579,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
10 EBI-745579,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
11 EBI-745579,EBI-8642021 RBMY1F  
  .RNA splicing
.spermatogenesis
.mRNA processing
.RNA binding
.nucleotide binding
.nucleus
12 EBI-745579,EBI-745604 RSRP1  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder133
blood106
bone111
brain74
cervix103
connective tissue26
embryonic tissue61
esophagus99
eye57
heart55
intestine150
kidney52
larynx85
liver102
lung68
lymph203
lymph node66
mammary gland119
mouth166
muscle56
nerve64
ovary39
pancreas70
placenta123
prostate73
salivary gland49
skin61
spleen74
stomach41
testis96
thymus75
thyroid236
tonsil58
trachea38
uterus94
vascular38
Health State
TissuesTPM*
normal63
bladder carcinoma227
breast (mammary gland) tumor150
cervical tumor86
chondrosarcoma84
colorectal tumor204
esophageal tumor57
gastrointestinal tumor42
germ cell tumor91
glioma46
head and neck tumor141
kidney tumor145
leukemia63
liver tumor156
lung tumor58
lymphoma124
non-neoplasia20
ovarian tumor52
pancreatic tumor123
primitive neuroectodermal tumor of the CNS173
prostate cancer67
retinoblastoma64
skin tumor95
soft tissue/muscle tissue tumor31
uterine tumor110
Developmental Stage
TissuesTPM*
adult94
embryoid body42
blastocyst81
fetus55
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.6
adrenal gland28.7
appendix42.1
bone marrow167.1
cerebral cortex18.8
colon36
duodenum35.1
esophagus47.3
gallbladder44.2
heart muscle30.8
kidney25.1
liver16.3
lung42
lymph node57.2
ovary43.2
pancreas24.2
placenta41.4
prostate42.2
salivary gland46.6
skin39
small intestine36.2
spleen54.8
stomach38.5
testis53
thyroid gland39.5
urinary bladder41.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastHigh
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602990, gene) Cdc-like kinase 3; CLK3OMIM


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