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> Protein (NX_P49792)
Protein (NX_P49792)
Protein
Gene SymbolRANBP2 to neXtProt (NX_P49792)
DescriptionE3 SUMO-protein ligase RanBP2
Chromosome2
Location2q12.3 (109335937 ~ 109402267) to Ensembl
Sequene Features : Isoforms 1, Variants 365, PTMs 58 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to heat
.regulation of gluconeogenesis involved in cellular glucose homeostasis
.transmembrane transport
  + 21 more...
.ligase activity
.Ran GTPase binding
.zinc ion binding
  + 2 more...
.nuclear pore nuclear basket
.nuclear inclusion body
.nuclear membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 365 58
2014-09-19protein level
1 271 58
2014-05-27protein level
1 270 83
2014-02-25protein level
1 268 80
2013-12-09protein level
1 231 80
2013-11-01protein level
1 223 75
2013-09-12protein level
1 223 75
2013-08-17protein level
1 223 75
2013-07-15protein level
1 158 69
2013-06-11protein level
1 158 69
2013-02-12protein level
1 81 72
2012-12-20protein level
1 79 72
2012-10-30protein level
1 82 72
2012-10-07protein level
1 82 72
2012-08-24protein level
1 77 72
2012-07-28protein level
1 77 72
2012-06-08protein level
1 103 72
2012-05-07protein level
1 91 72
2012-04-10protein level
1 91 72
2012-01-13protein level
1 68 72
2011-12-20protein level
1 68 72
2011-11-11protein level
1 68 65
2011-08-23protein level
1 68 65
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49792-1
107 0 51 357973.0484
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-973138,EBI-716346 PARK2  
  .negative regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.negative regulation of spontaneous neurotransmitter secretion
  + 78 more...
.F-box domain binding
.ubiquitin-specific protease binding
.cullin family protein binding
  + 21 more...
.Parkin-FBXW7-Cul1 ubiquitin ligase complex
.Lewy body
.perinuclear region of cytoplasm
  + 9 more...
2 EBI-973138,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-973138,EBI-5658852 PDLIM3  
  .heart development
.actin filament organization
.structural constituent of muscle
.zinc ion binding
.Z disc
.actin cytoskeleton
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites25
bladder167
blood106
bone55
bone marrow61
brain53
connective tissue53
ear62
embryonic tissue89
esophagus99
eye95
heart67
intestine86
kidney75
larynx42
liver102
lung83
lymph node233
mammary gland119
mouth136
muscle65
nerve64
ovary118
pancreas65
pharynx49
pituitary gland302
placenta109
prostate89
skin52
spleen56
stomach146
testis98
thymus62
thyroid42
trachea231
umbilical cord145
uterus129
vascular58
Health State
TissuesTPM*
normal88
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor75
chondrosarcoma96
colorectal tumor124
esophageal tumor115
gastrointestinal tumor75
germ cell tumor98
glioma46
head and neck tumor82
kidney tumor58
leukemia95
liver tumor83
lung tumor19
non-neoplasia124
ovarian tumor118
pancreatic tumor9
prostate cancer67
retinoblastoma107
skin tumor47
uterine tumor177
Developmental Stage
TissuesTPM*
adult110
embryoid body142
blastocyst65
neonate96
fetus61
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.2
adrenal gland25.7
appendix18
bone marrow29.7
cerebral cortex15.6
colon18.5
duodenum12.6
esophagus15.2
gallbladder16.6
heart muscle11.2
kidney18.2
liver10.1
lung13.4
lymph node18.7
ovary18.8
pancreas10.3
placenta16
prostate20.7
salivary gland13.3
skin15.3
small intestine13.2
spleen13.3
stomach17
testis23.7
thyroid gland29.8
urinary bladder16.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601181, gene) Ran-binding protein 2; RANBP2OMIM
2(#608033, phenotype) Encephalopathy, acute, infection-induced, susceptibility to, 3; IIAE3OMIM


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