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> Protein (NX_P49815)
Protein (NX_P49815)
Protein
Gene SymbolTSC2 to neXtProt (NX_P49815)
DescriptionTuberin
Chromosome16
Location16p13.3 (2097466 ~ 2138716) to Ensembl
Sequene Features : Isoforms 8, Variants 364, PTMs 32 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein kinase B signaling
.regulation of cell cycle
.protein heterooligomerization
  + 39 more...
.protein homodimerization activity
.phosphatase binding
.GTPase activator activity
.perinuclear region of cytoplasm
.neuronal cell body
.TSC1-TSC2 complex
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 364 32
2014-09-19protein level
8 323 32
2014-05-27protein level
7 323 32
2014-02-25protein level
6 320 31
2013-12-09protein level
6 339 31
2013-11-01protein level
6 336 30
2013-09-12protein level
6 336 31
2013-08-17protein level
6 336 31
2013-07-15protein level
6 295 22
2013-06-11protein level
6 295 22
2013-02-12protein level
6 271 140
2012-12-20protein level
6 170 140
2012-10-30protein level
6 204 140
2012-10-07protein level
6 204 24
2012-08-24protein level
6 198 24
2012-07-28protein level
6 203 24
2012-06-08protein level
6 226 24
2012-05-07protein level
6 209 24
2012-04-10protein level
6 209 24
2012-01-13protein level
6 263 24
2011-12-20protein level
6 263 24
2011-11-11protein level
6 263 24
2011-08-23protein level
6 261 21
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49815-1
0 89 0 200480.8115
NX_P49815-2
0 86 0 195722.3005
NX_P49815-3
0 86 0 195635.2687
NX_P49815-4
0 88 0 197971.6376
NX_P49815-5
0 85 0 193126.0948
NX_P49815-6
0 81 0 189177.849
NX_P49815-7
1 82 0 187836.183
NX_P49815-8
5 7 0 25756.056
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396587,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
2 EBI-396587,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
3 EBI-396587,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
4 EBI-396587,EBI-1047085 TSC1  
  .activation of GTPase activity
.cardiac muscle cell differentiation
.positive regulation of focal adhesion assembly
  + 29 more...
.chaperone binding
.protein N-terminus binding
.GTPase regulator activity
.protein complex
.intracellular membrane-bounded organelle
.TSC1-TSC2 complex
  + 8 more...
5 EBI-396587,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites50
bladder66
blood57
bone41
bone marrow41
brain97
cervix103
connective tissue53
ear62
embryonic tissue89
eye110
heart11
intestine99
kidney66
larynx468
liver9
lung80
lymph609
lymph node167
mammary gland39
mouth196
muscle75
nerve257
ovary108
pancreas93
parathyroid97
pituitary gland121
placenta74
prostate110
skin132
spleen131
stomach73
testis130
thymus464
thyroid107
trachea96
uterus56
Health State
TissuesTPM*
normal82
bladder carcinoma113
breast (mammary gland) tumor42
cervical tumor144
chondrosarcoma72
colorectal tumor97
gastrointestinal tumor92
germ cell tumor64
glioma111
head and neck tumor186
kidney tumor87
leukemia63
liver tumor10
lung tumor126
lymphoma387
non-neoplasia82
ovarian tumor91
pancreatic tumor123
primitive neuroectodermal tumor of the CNS31
prostate cancer96
retinoblastoma129
skin tumor151
uterine tumor66
Developmental Stage
TissuesTPM*
adult90
embryoid body100
blastocyst162
neonate32
fetus68
infant85
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22
adrenal gland45.8
appendix23.2
bone marrow20.7
cerebral cortex28.5
colon21.4
duodenum23.7
esophagus19.1
gallbladder25
heart muscle16.7
kidney22.6
liver13.3
lung30.5
lymph node22.9
ovary33.4
pancreas13.7
placenta18
prostate27.3
salivary gland35
skin43.2
small intestine22.3
spleen35.4
stomach33.4
testis46.4
thyroid gland31.7
urinary bladder18.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191092, gene) Tsc2 gene; TSC2OMIM
2(#606690, phenotype) Lymphangioleiomyomatosis; LAMOMIM
3(#613254, phenotype) Tuberous sclerosis 2; TSC2OMIM
4hamartoma;renal cell;Tuberous sclerosis 2CGP


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