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> Protein (NX_P49841)
Protein (NX_P49841)
Protein
Gene SymbolGSK3B to neXtProt (NX_P49841)
DescriptionGlycogen synthase kinase-3 beta
Chromosome3
Location3q13.33 (119540170 ~ 119813264) to Ensembl
Sequene Features : Isoforms 2, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 57 5
2014-09-19protein level
2 46 5
2014-05-27protein level
2 46 10
2014-02-25protein level
2 46 10
2013-12-09protein level
2 35 10
2013-11-01protein level
2 33 8
2013-09-12protein level
2 33 10
2013-08-17protein level
2 33 10
2013-07-15protein level
2 19 9
2013-06-11protein level
2 19 9
2013-02-12protein level
2 8 34
2012-12-20protein level
2 8 34
2012-10-30protein level
2 12 34
2012-10-07protein level
2 12 17
2012-08-24protein level
2 5 17
2012-07-28protein level
2 5 17
2012-06-08protein level
2 10 17
2012-05-07protein level
2 10 17
2012-04-10protein level
2 10 17
2012-01-13protein level
2 9 17
2011-12-20protein level
2 9 17
2011-11-11protein level
2 9 17
2011-08-23protein level
2 7 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49841-1
0 15 6 46714.8056
NX_P49841-2
1 15 6 48003.3816
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373586,EBI-710484 AXIN1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
2 EBI-373586,EBI-718185 DEAF1  
  .embryonic skeletal system development
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 8 more...
.metal ion binding
.DNA binding
.cytoplasm
.nucleolus
.transcription factor complex
  + 3 more...
3 EBI-373586,EBI-910915 LRP6  
  .negative regulation of planar cell polarity pathway involved in neural tube closure
.negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
.negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
  + 77 more...
.coreceptor activity involved in Wnt signaling pathway
.Wnt-activated receptor activity
.protein homodimerization activity
  + 8 more...
.synapse
.receptor complex
.neuronal cell body
  + 7 more...
4 EBI-373586,EBI-358329 UBR5  
  .negative regulation of double-strand break repair
.negative regulation of histone H2A K63-linked ubiquitination
.positive regulation of canonical Wnt signaling pathway
  + 9 more...
.ubiquitin-ubiquitin ligase activity
.ligase activity
.zinc ion binding
  + 2 more...
.membrane
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-373586,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
6 EBI-373586,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
7 EBI-373586,EBI-366182 MAPT  
  .regulation of microtubule-based movement
.generation of neurons
.axon extension
  + 13 more...
.lipoprotein particle binding
.apolipoprotein binding
.enzyme binding
  + 3 more...
.tubulin complex
.cytoplasmic ribonucleoprotein granule
.nuclear periphery
  + 7 more...
8 EBI-373586,EBI-740553 GYS1  
  .small molecule metabolic process
.heart development
.glucose metabolic process
  + 2 more...
.glycogen synthase activity, transferring glucose-1-phosphate
.protein kinase binding
.glucose binding
.glycogen (starch) synthase activity
.inclusion body
.membrane
.cytosol
.cytoplasm
9 EBI-373586,EBI-476586 PRKACA  
  .regulation of tight junction assembly
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.cell communication by electrical coupling involved in cardiac conduction
  + 47 more...
.protein kinase A regulatory subunit binding
.ubiquitin protein ligase binding
.protein kinase binding
  + 3 more...
.ciliary base
.sperm midpiece
.extracellular exosome
  + 11 more...
10 EBI-373586,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
11 EBI-373586,EBI-296058 AKT2  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of cell motility
.positive regulation of protein targeting to membrane
  + 24 more...
.kinase activity
.ATP binding
.protein serine/threonine kinase activity
.ruffle membrane
.cell cortex
.plasma membrane
  + 3 more...
12 EBI-373586,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
13 EBI-373586,EBI-985879 SNCA  
  .regulation of reactive oxygen species biosynthetic process
.regulation of synaptic vesicle recycling
.positive regulation of hydrogen peroxide catabolic process
  + 63 more...
.phosphoprotein binding
.tau protein binding
.dynein binding
  + 14 more...
.perinuclear region of cytoplasm
.fibril
.terminal bouton
  + 21 more...
14 EBI-373586,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
15 EBI-373586,EBI-357837 RELB  
  .cellular response to osmotic stress
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 12 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.I-kappaB/NF-kappaB complex
.cytosol
.microtubule organizing center
  + 3 more...
16 EBI-373586,EBI-702370 TRIM29  
  .negative regulation of protein localization to nucleus
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
17 EBI-373586,EBI-1567153 SMAD1  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.positive regulation of cartilage development
  + 28 more...
.I-SMAD binding
.co-SMAD binding
.metal ion binding
  + 8 more...
.protein complex
.integral component of membrane
.cytosol
  + 6 more...
18 EBI-373586,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
19 EBI-373586,EBI-2871881 DAB2IP  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron migration
.negative regulation of cyclin catabolic process
  + 69 more...
.14-3-3 protein binding
.phosphatidylinositol-4-phosphate binding
.protein phosphatase 2A binding
  + 15 more...
.AIP1-IRE1 complex
.parallel fiber
.extracellular exosome
  + 10 more...
20 EBI-373586,EBI-6424915 STYK1  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 2 more...
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.integral component of membrane
.plasma membrane
21 EBI-373586,EBI-3942619 ZFPM1  
  .transcriptional activation by promoter-enhancer looping
.atrial septum morphogenesis
.ventricular septum morphogenesis
  + 24 more...
.metal ion binding
.transcription factor binding
.DNA binding
  + 2 more...
.transcriptional repressor complex
.cytoplasm
.transcription factor complex
  + 2 more...
22 EBI-373586,EBI-1164022 NIN  
  .centrosome-templated microtubule nucleation
.centrosome localization
.microtubule anchoring at centrosome
.GTP binding
.calcium ion binding
.microtubule
.centriole
.centrosome
  + 2 more...
23 EBI-373586,EBI-1104509 BICD1  
  .negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
.regulation of proteinase activated receptor activity
.negative regulation of phospholipase C activity
  + 9 more...
.dynein binding
.dynactin binding
.proteinase activated receptor binding
  + 3 more...
.host cell viral assembly compartment
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 5 more...
24 EBI-373586,EBI-3951744 DACT1  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of Wnt signaling pathway, planar cell polarity pathway
.negative regulation of canonical Wnt signaling pathway
  + 14 more...
.delta-catenin binding
.protein kinase A binding
.beta-catenin binding
.protein kinase C binding
.synapse
.beta-catenin destruction complex
.cell junction
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
blood49
bone13
brain21
cervix61
connective tissue174
embryonic tissue32
esophagus49
eye57
heart33
intestine43
kidney33
liver24
lung20
lymph node122
mammary gland39
mouth15
muscle28
ovary39
pancreas42
parathyroid194
pharynx49
pituitary gland121
placenta42
prostate42
skin71
stomach31
testis39
thymus25
thyroid21
trachea19
uterus17
Health State
TissuesTPM*
normal37
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma12
colorectal tumor44
esophageal tumor57
gastrointestinal tumor42
germ cell tumor45
glioma18
head and neck tumor14
kidney tumor29
leukemia74
lung tumor19
non-neoplasia31
ovarian tumor13
primitive neuroectodermal tumor of the CNS15
prostate cancer57
retinoblastoma64
skin tumor95
soft tissue/muscle tissue tumor215
uterine tumor11
Developmental Stage
TissuesTPM*
adult56
embryoid body71
blastocyst32
neonate32
fetus35
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.5
adrenal gland16.7
appendix16.1
bone marrow18.3
cerebral cortex24.5
colon18.7
duodenum16.9
esophagus21.6
gallbladder18.7
heart muscle20.1
kidney12.1
liver13.4
lung16.1
lymph node15.2
ovary13
pancreas8.5
placenta23.6
prostate10.3
salivary gland12.5
skin14.4
small intestine18.1
spleen14.9
stomach13.7
testis33.3
thyroid gland23.3
urinary bladder19.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605004, gene) Glycogen synthase kinase 3-beta; GSK3BOMIM


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