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> Protein (NX_P49959)
Protein (NX_P49959)
Protein
Gene SymbolMRE11A to neXtProt (NX_P49959)
DescriptionDouble-strand break repair protein MRE11A
Chromosome11
Location11q21 (94152895 ~ 94227074) to Ensembl
Sequene Features : Isoforms 3, Variants 93, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleic acid phosphodiester bond hydrolysis
.innate immune response
.positive regulation of kinase activity
  + 22 more...
.manganese ion binding
.3'-5' exonuclease activity
.protein C-terminus binding
  + 5 more...
.site of double-strand break
.Mre11 complex
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 93 13
2014-09-19protein level
2 79 13
2014-05-27protein level
2 79 13
2014-02-25protein level
2 78 13
2013-12-09protein level
2 65 13
2013-11-01protein level
2 65 6
2013-09-12protein level
2 65 5
2013-08-17protein level
2 65 5
2013-07-15protein level
2 44 4
2013-06-11protein level
2 44 4
2013-02-12protein level
2 28 10
2012-12-20protein level
2 28 10
2012-10-30protein level
2 31 10
2012-10-07protein level
2 31 5
2012-08-24protein level
2 25 5
2012-07-28protein level
2 25 5
2012-06-08protein level
2 26 5
2012-05-07protein level
2 26 5
2012-04-10protein level
2 26 5
2012-01-13protein level
2 16 5
2011-12-20protein level
2 16 5
2011-11-11protein level
2 16 5
2011-08-23protein level
2 16 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P49959-1
0 32 0 80543.0884
NX_P49959-2
0 30 0 77593.6397
NX_P49959-3
1 31 0 81019.3587
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396513,EBI-494844 NBN  
  .intrinsic apoptotic signaling pathway
.meiotic cell cycle
.neuromuscular process controlling balance
  + 16 more...
.protein N-terminus binding
.transcription factor binding
.damaged DNA binding
.nuclear inclusion body
.site of double-strand break
.Mre11 complex
  + 6 more...
2 EBI-396513,EBI-968231 RAD17  
  .regulation of phosphorylation
.negative regulation of DNA replication
.mitotic cell cycle checkpoint
  + 5 more...
.ATP binding
.DNA clamp loader activity
.Rad17 RFC-like complex
.nucleoplasm
.nucleus
3 EBI-396513,EBI-494830 H2AFX  
  .meiotic cell cycle
.positive regulation of DNA repair
.response to ionizing radiation
  + 7 more...
.histone binding
.enzyme binding
.damaged DNA binding
.DNA binding
.extracellular exosome
.site of double-strand break
.replication fork
  + 7 more...
4 EBI-396513,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-396513,EBI-359343 FANCD2  
  .response to gamma radiation
.gamete generation
.synapsis
.DNA repair
.DNA polymerase binding .intracellular membrane-bounded organelle
.Golgi apparatus
.nucleoplasm
.condensed chromosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood16
bone41
bone marrow41
brain11
cervix41
connective tissue13
embryonic tissue61
esophagus99
eye19
intestine30
kidney23
larynx85
liver34
lung29
lymph node55
mammary gland26
mouth105
muscle37
nerve64
ovary19
parathyroid97
pharynx24
placenta35
prostate21
skin28
spleen37
stomach10
testis20
thymus25
thyroid21
uterus25
Health State
TissuesTPM*
normal26
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma36
colorectal tumor17
esophageal tumor115
gastrointestinal tumor8
germ cell tumor56
glioma18
head and neck tumor74
kidney tumor14
liver tumor20
lymphoma27
non-neoplasia10
primitive neuroectodermal tumor of the CNS23
prostate cancer28
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult27
embryoid body42
blastocyst65
neonate32
fetus39
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.6
adrenal gland6.4
appendix12.1
bone marrow11.3
cerebral cortex5.1
colon7.9
duodenum6.5
esophagus7.5
gallbladder10
heart muscle4.2
kidney6.4
liver3.7
lung7.3
lymph node12.3
ovary10
pancreas2.8
placenta9.4
prostate8.9
salivary gland5.6
skin12
small intestine6.6
spleen11.3
stomach7
testis8.5
thyroid gland7.2
urinary bladder11.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600814, gene) Meiotic recombination 11, s. cerevisiae, homolog of, a; MRE11AOMIM
2(#604391, phenotype) Ataxia-telangiectasia-like disorder; ATLDOMIM


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