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> Protein (NX_P50221)
Protein (NX_P50221)
Protein
Gene SymbolMEOX1 to neXtProt (NX_P50221)
DescriptionHomeobox protein MOX-1
Chromosome17
Location17q21.31 (41717756 ~ 41739322) to Ensembl
Sequene Features : Isoforms 3, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 54 0
2014-09-19protein level
3 38 0
2014-05-27transcript level
3 37 0
2014-02-25transcript level
3 36 0
2013-12-09transcript level
3 29 0
2013-11-01transcript level
3 28 0
2013-09-12transcript level
3 28 0
2013-08-17transcript level
3 28 0
2013-07-15transcript level
2 21 0
2013-06-11transcript level
2 21 0
2013-02-12transcript level
2 10 0
2012-12-20transcript level
2 10 0
2012-10-30transcript level
2 12 0
2012-10-07transcript level
2 12 0
2012-08-24transcript level
2 11 0
2012-07-28transcript level
2 11 0
2012-06-08transcript level
2 11 0
2012-05-07transcript level
2 11 0
2012-04-10transcript level
1 9 0
2012-01-13transcript level
1 4 0
2011-12-20transcript level
1 4 0
2011-11-11transcript level
1 4 0
2011-08-23transcript level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P50221-1
0 9 1 27979.5261
NX_P50221-2
3 5 0 19545.2079
NX_P50221-3
1 4 1 15618.7418
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2864512,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
2 EBI-2864512,EBI-8646694 DCX  
  .dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
3 EBI-2864512,EBI-725145 CIAO1  
  .small molecule metabolic process
.iron-sulfur cluster assembly
.positive regulation of cell proliferation
  + 2 more...
.N/A .CIA complex
.MMXD complex
4 EBI-2864512,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
5 EBI-2864512,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
6 EBI-2864512,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
7 EBI-2864512,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
8 EBI-2864512,EBI-1993619 UBXN2B  
  .membrane fusion
.regulation of catalytic activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin binding
.protein phosphatase type 1 regulator activity
.cytosol
.Golgi apparatus
.endoplasmic reticulum
.nucleus
9 EBI-2864512,EBI-2798044 QRICH1  
  .N/A .N/A .nucleoplasm
10 EBI-2864512,EBI-10244544 PAGE3  
  .N/A .N/A .N/A
11 EBI-2864512,EBI-2340879 UBE2R2  
  .protein K48-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.protein monoubiquitination
.ubiquitin conjugating enzyme activity
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.cytoplasm
12 EBI-2864512,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
13 EBI-2864512,EBI-10281234 NEIL2  
  .depyrimidination
.nucleotide-excision repair
.base-excision repair, AP site formation
  + 2 more...
.hydrolase activity, hydrolyzing N-glycosyl compounds
.zinc ion binding
.DNA-(apurinic or apyrimidinic site) lyase activity
.damaged DNA binding
.spindle microtubule
.cytoplasm
.nucleoplasm
14 EBI-2864512,EBI-10292696 CIB3  
  .N/A .calcium ion binding .N/A
15 EBI-2864512,EBI-745392 SYT17  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.plasma membrane
.trans-Golgi network
16 EBI-2864512,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
17 EBI-2864512,EBI-372578 NAGK  
  .carbohydrate phosphorylation
.N-acetylneuraminate catabolic process
.N-acetylmannosamine metabolic process
.N-acetylglucosamine metabolic process
.N-acetylglucosamine kinase activity
.N-acylmannosamine kinase activity
.ATP binding
.extracellular exosome
18 EBI-2864512,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood8
connective tissue13
heart11
intestine12
kidney9
liver9
lung2
mouth15
muscle65
ovary68
placenta3
prostate15
skin9
testis13
uterus12
vascular19
Health State
TissuesTPM*
normal10
chondrosarcoma12
germ cell tumor30
kidney tumor29
liver tumor20
non-neoplasia10
ovarian tumor91
skin tumor15
soft tissue/muscle tissue tumor55
uterine tumor11
Developmental Stage
TissuesTPM*
adult6
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.3
appendix4.3
colon3
duodenum1.4
esophagus3.8
gallbladder6.8
heart muscle18.1
lung1.5
lymph node7.2
prostate1.9
salivary gland1.2
skin4.4
spleen9.4
testis1.7
urinary bladder9.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(%214300, phenotype) Klippel-feil syndrome 2, autosomal recessive; KFS2OMIM
2(*600147, gene) Mesenchyme homeobox 1; MEOX1OMIM


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