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> Protein (NX_P50281)
Protein (NX_P50281)
Protein
Gene SymbolMMP14 to neXtProt (NX_P50281)
DescriptionMatrix metalloproteinase-14
Chromosome14
Location14q11.2 (23305766 ~ 23318236) to Ensembl
Sequene Features : Isoforms 1, Variants 63, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.craniofacial suture morphogenesis
.negative regulation of focal adhesion assembly
.tissue remodeling
  + 22 more...
.peptidase activator activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.melanosome
.extracellular matrix
.focal adhesion
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 63 8
2014-09-19protein level
1 49 8
2014-05-27protein level
1 49 8
2014-02-25protein level
1 48 8
2013-12-09protein level
1 38 9
2013-11-01protein level
1 36 9
2013-09-12protein level
1 36 9
2013-08-17protein level
1 36 8
2013-07-15protein level
1 27 2
2013-06-11protein level
1 27 2
2013-02-12protein level
1 18 2
2012-12-20protein level
1 18 2
2012-10-30protein level
1 22 2
2012-10-07protein level
1 22 2
2012-08-24protein level
1 21 2
2012-07-28protein level
1 21 2
2012-06-08protein level
1 23 2
2012-05-07protein level
1 18 2
2012-04-10protein level
1 18 2
2012-01-13protein level
1 10 2
2011-12-20protein level
1 10 2
2011-11-11protein level
1 10 2
2011-08-23protein level
1 10 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P50281-1
21 0 0 65851.7726
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-992788,EBI-1033507 TIMP2  
  .cellular response to organic substance
.negative regulation of membrane protein ectodomain proteolysis
.negative regulation of metalloenzyme activity
  + 15 more...
.metal ion binding
.metalloendopeptidase inhibitor activity
.enzyme activator activity
.protease binding
.extracellular exosome
.neuronal cell body
.growth cone
  + 5 more...
2 EBI-992788,EBI-725780 LUM  
  .response to growth factor
.cartilage development
.positive regulation of transcription from RNA polymerase II promoter
  + 10 more...
.collagen binding
.extracellular matrix structural constituent
.extracellular exosome
.lysosomal lumen
.Golgi lumen
  + 4 more...
3 EBI-992788,EBI-444403 LIMK1  
  .positive regulation of stress fiber assembly
.negative regulation of ubiquitin-protein transferase activity
.ephrin receptor signaling pathway
  + 11 more...
.heat shock protein binding
.zinc ion binding
.ATP binding
  + 2 more...
.neuron projection
.focal adhesion
.cytosol
  + 2 more...
4 EBI-992788,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
5 EBI-992788,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
6 EBI-992788,EBI-992807 ADI1  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.L-methionine biosynthetic process from methylthioadenosine
  + 2 more...
.oxidoreductase activity
.acireductone dioxygenase [iron(II)-requiring] activity
.iron ion binding
.plasma membrane
.cytosol
.Golgi apparatus
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone125
brain24
connective tissue53
embryonic tissue108
esophagus248
eye28
heart11
intestine43
kidney47
larynx809
lung104
mammary gland92
mouth166
muscle18
nerve64
pancreas14
pharynx98
placenta28
prostate21
skin113
spleen18
stomach10
testis20
thymus50
thyroid214
trachea19
uterus73
vascular174
Health State
TissuesTPM*
normal35
bladder carcinoma170
breast (mammary gland) tumor118
chondrosarcoma181
colorectal tumor35
esophageal tumor289
germ cell tumor22
glioma149
head and neck tumor261
kidney tumor58
lung tumor155
non-neoplasia20
pancreatic tumor28
skin tumor119
soft tissue/muscle tissue tumor63
uterine tumor99
Developmental Stage
TissuesTPM*
adult68
embryoid body271
blastocyst16
neonate64
fetus37
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue51.4
adrenal gland17.4
appendix51.7
bone marrow1.1
cerebral cortex7.4
colon37
duodenum35.1
esophagus40.5
gallbladder153
heart muscle13.7
kidney20
liver7.2
lung42.1
lymph node24.3
ovary54
pancreas14.1
placenta114.2
prostate32.5
salivary gland21.8
skin58.6
small intestine35.9
spleen21.9
stomach39
testis17.6
thyroid gland20.2
urinary bladder122.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(^277950, moved/removed) Moved to 259600OMIM
2(*600754, gene) Matrix metalloproteinase 14; MMP14OMIM


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