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> Protein (NX_P50402)
Protein (NX_P50402)
Protein
Gene SymbolEMD to neXtProt (NX_P50402)
DescriptionEmerin
ChromosomeX
LocationXq28 (153607557 ~ 153609883) to Ensembl
Sequene Features : Isoforms 1, Variants 40, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to growth factor stimulus
.regulation of canonical Wnt signaling pathway
.negative regulation of fibroblast proliferation
  + 8 more...
.beta-tubulin binding
.actin binding
.nuclear membrane
.integral component of membrane
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 40 16
2014-09-19protein level
1 31 16
2014-05-27protein level
1 31 16
2014-02-25protein level
1 29 16
2013-12-09protein level
1 25 16
2013-11-01protein level
1 24 15
2013-09-12protein level
1 24 15
2013-08-17protein level
1 24 15
2013-07-15protein level
1 13 15
2013-06-11protein level
1 13 15
2013-02-12protein level
1 9 24
2012-12-20protein level
1 9 24
2012-10-30protein level
1 9 24
2012-10-07protein level
1 9 24
2012-08-24protein level
1 9 24
2012-07-28protein level
1 9 24
2012-06-08protein level
1 13 24
2012-05-07protein level
1 13 24
2012-04-10protein level
1 13 24
2012-01-13protein level
1 10 24
2011-12-20protein level
1 10 24
2011-11-11protein level
1 10 24
2011-08-23protein level
1 10 23
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P50402-1
13 0 0 28975.8465
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-489887,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
2 EBI-489887,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
3 EBI-489887,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
4 EBI-489887,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
5 EBI-489887,EBI-10268010 MAB21L3  
  .N/A .N/A .N/A
6 EBI-489887,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
7 EBI-489887,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
8 EBI-489887,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
9 EBI-489887,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
10 EBI-489887,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
11 EBI-489887,EBI-437804 BCLAF1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of response to DNA damage stimulus
.positive regulation of DNA-templated transcription, initiation
  + 5 more...
.poly(A) RNA binding
.DNA binding
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
12 EBI-489887,EBI-10198848 LUZP4  
  .N/A .N/A .nucleus
13 EBI-489887,EBI-1044964 SUN2  
  .nuclear matrix anchoring at nuclear membrane
.cytoskeletal anchoring at nuclear membrane
.centrosome localization
  + 5 more...
.identical protein binding
.microtubule binding
.lamin binding
.LINC complex
.nuclear membrane
.endosome membrane
  + 4 more...
14 EBI-489887,EBI-2602396 ABT1  
  .small-subunit processome assembly
.spinal cord motor neuron differentiation
.transcription from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.transcription coactivator activity
.DNA binding
.nucleotide binding
.nucleolus
.transcription factor complex
.nucleus
15 EBI-489887,EBI-749023 ZNF232  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
16 EBI-489887,EBI-765817 TRAF3IP3  
  .N/A .N/A .integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood24
bone181
brain17
cervix82
connective tissue26
embryonic tissue61
eye62
heart11
intestine25
kidney66
larynx85
liver24
lung23
lymph135
lymph node77
mammary gland79
muscle18
nerve64
ovary128
pancreas98
parathyroid145
pituitary gland60
placenta74
prostate121
skin256
testis9
thyroid21
tonsil117
uterus64
vascular19
Health State
TissuesTPM*
normal27
adrenal tumor79
breast (mammary gland) tumor107
cervical tumor57
chondrosarcoma144
colorectal tumor8
gastrointestinal tumor16
germ cell tumor72
glioma18
head and neck tumor22
kidney tumor43
liver tumor41
lung tumor48
lymphoma124
ovarian tumor144
pancreatic tumor133
primitive neuroectodermal tumor of the CNS125
prostate cancer202
retinoblastoma43
skin tumor414
soft tissue/muscle tissue tumor7
uterine tumor144
Developmental Stage
TissuesTPM*
adult52
embryoid body57
blastocyst81
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.3
adrenal gland46
appendix38.3
bone marrow58.5
cerebral cortex23.8
colon30.3
duodenum28
esophagus38.8
gallbladder45.2
heart muscle45
kidney33.2
liver21.3
lung39.7
lymph node40.4
ovary67.1
pancreas29.5
placenta33.8
prostate47
salivary gland43.2
skin32.6
small intestine26.2
spleen41.4
stomach31
testis30.1
thyroid gland62.6
urinary bladder39.9
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineLow
smooth muscleHigh
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300384, gene) Emerin; EMDOMIM
2(#310300, phenotype) Emery-dreifuss muscular dystrophy 1, x-linked; EDMD1OMIM


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2014-2019 (C) Yonsei Proteome Research Center