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> Protein (NX_P50570)
Protein (NX_P50570)
Protein
Gene SymbolDNM2 to neXtProt (NX_P50570)
DescriptionDynamin-2
Chromosome19
Location19p13.2 (10828755 ~ 10944164) to Ensembl
Sequene Features : Isoforms 5, Variants 133, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of membrane tubulation
.membrane organization
.regulation of nitric-oxide synthase activity
  + 16 more...
.enzyme binding
.SH3 domain binding
.microtubule binding
  + 2 more...
.extracellular exosome
.postsynaptic membrane
.endocytic vesicle membrane
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 133 9
2014-09-19protein level
5 104 9
2014-05-27protein level
5 104 12
2014-02-25protein level
5 100 11
2013-12-09protein level
5 88 11
2013-11-01protein level
5 82 7
2013-09-12protein level
5 82 10
2013-08-17protein level
5 82 10
2013-07-15protein level
3 61 10
2013-06-11protein level
3 61 10
2013-02-12protein level
3 41 27
2012-12-20protein level
3 41 27
2012-10-30protein level
3 45 27
2012-10-07protein level
3 45 9
2012-08-24protein level
2 42 9
2012-07-28protein level
2 33 9
2012-06-08protein level
2 36 9
2012-05-07protein level
2 28 9
2012-04-10protein level
2 28 9
2012-01-13protein level
2 21 9
2011-12-20protein level
2 21 9
2011-11-11protein level
2 21 6
2011-08-23protein level
2 21 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P50570-1
0 29 11 98002.8821
NX_P50570-2
0 29 11 97590.6511
NX_P50570-3
0 28 12 97492.6286
NX_P50570-4
0 28 12 97904.8596
NX_P50570-5
1 28 11 97915.8503
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346547,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
2 EBI-346547,EBI-4279548 MYO1E  
  .glomerular visceral epithelial cell development
.platelet-derived growth factor receptor signaling pathway
.post-embryonic hemopoiesis
  + 7 more...
.actin filament binding
.ATPase activity, coupled
.phosphatidylinositol binding
  + 4 more...
.extracellular exosome
.clathrin-coated vesicle
.myosin complex
  + 5 more...
3 EBI-346547,EBI-351886 CTTN  
  .negative regulation of extrinsic apoptotic signaling pathway
.lamellipodium organization
.dendritic spine maintenance
  + 12 more...
.profilin binding .mitotic spindle midzone
.extracellular exosome
.dendritic spine
  + 10 more...
4 EBI-346547,EBI-602041 ITSN1  
  .apoptotic signaling pathway
.positive regulation of protein kinase B signaling
.regulation of small GTPase mediated signal transduction
  + 8 more...
.proline-rich region binding
.protein complex scaffold
.kinase activator activity
  + 3 more...
.synapse
.neuron projection
.endocytic vesicle
  + 5 more...
5 EBI-346547,EBI-1049056 AHI1  
  .otic vesicle development
.left/right axis specification
.Kupffer's vesicle development
  + 22 more...
.identical protein binding .primary cilium
.ciliary basal body
.TCTN-B9D complex
  + 7 more...
6 EBI-346547,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
7 EBI-346547,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
8 EBI-346547,EBI-1049513 SH3BP4  
  .cellular response to amino acid stimulus
.protein localization to lysosome
.regulation of catalytic activity
  + 6 more...
.identical protein binding
.Ras GTPase binding
.GDP-dissociation inhibitor activity
.extracellular exosome
.clathrin-coated vesicle
.coated pit
  + 2 more...
9 EBI-346547,EBI-742503 PACSIN2  
  .membrane tubulation
.caveolin-mediated endocytosis
.caveola assembly
  + 5 more...
.phosphatidic acid binding
.identical protein binding
.cytoskeletal protein binding
.transporter activity
.extracellular exosome
.recycling endosome membrane
.intracellular membrane-bounded organelle
  + 12 more...
10 EBI-346547,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder100
blood212
bone41
bone marrow41
brain81
cervix82
connective tissue20
embryonic tissue79
eye47
intestine245
kidney109
larynx553
liver63
lung44
lymph225
lymph node44
mammary gland112
mouth105
muscle37
nerve128
ovary206
pancreas84
pharynx24
pituitary gland60
placenta95
prostate52
salivary gland197
skin80
spleen56
stomach31
testis209
thymus263
thyroid64
trachea173
uterus73
vascular19
Health State
TissuesTPM*
normal68
bladder carcinoma113
breast (mammary gland) tumor139
cervical tumor57
chondrosarcoma36
colorectal tumor319
gastrointestinal tumor25
germ cell tumor136
glioma93
head and neck tumor209
kidney tumor203
leukemia201
liver tumor114
lung tumor97
lymphoma166
non-neoplasia62
ovarian tumor52
pancreatic tumor95
primitive neuroectodermal tumor of the CNS125
prostate cancer48
retinoblastoma86
skin tumor103
soft tissue/muscle tissue tumor87
uterine tumor77
Developmental Stage
TissuesTPM*
adult124
embryoid body114
blastocyst81
neonate32
fetus14
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue42.9
adrenal gland49.3
appendix82.7
bone marrow92
cerebral cortex35.7
colon103.1
duodenum75.6
esophagus61.7
gallbladder60.1
heart muscle64.3
kidney68.9
liver23
lung72.8
lymph node79.7
ovary35.4
pancreas30.7
placenta55
prostate43.9
salivary gland46.1
skin88
small intestine87
spleen86.4
stomach115.8
testis62.2
thyroid gland52.4
urinary bladder71.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
lungLow
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
pancreasMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineHigh
spleenHigh
stomach 1High
stomach 2High
testisMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#160150, phenotype) Myopathy, centronuclear, 1; CNM1OMIM
2(*602378, gene) Dynamin 2; DNM2OMIM
3(#606482, phenotype) Charcot-marie-tooth disease, dominant intermediate b; CMTDIBOMIM
4ETP ALLCGP


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