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> Protein (NX_P50616)
Protein (NX_P50616)
Protein
Gene SymbolTOB1 to neXtProt (NX_P50616)
DescriptionProtein Tob1
Chromosome17
Location17q21.33 (48939584 ~ 48945339) to Ensembl
Sequene Features : Isoforms 1, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 6 more...
.receptor tyrosine kinase binding
.SH3/SH2 adaptor activity
.transcription corepressor activity
.CCR4-NOT complex
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 48 1
2014-09-19protein level
1 41 1
2014-05-27protein level
1 41 1
2014-02-25protein level
1 41 1
2013-12-09protein level
1 30 1
2013-11-01protein level
1 27 1
2013-09-12protein level
1 27 1
2013-08-17protein level
1 27 1
2013-07-15protein level
1 14 1
2013-06-11protein level
1 14 1
2013-02-12protein level
1 11 1
2012-12-20protein level
1 13 1
2012-10-30protein level
1 15 1
2012-10-07protein level
1 15 1
2012-08-24protein level
1 11 1
2012-07-28protein level
1 11 1
2012-06-08protein level
1 11 1
2012-05-07protein level
1 11 1
2012-04-10protein level
1 11 1
2012-01-13protein level
1 4 1
2011-12-20protein level
1 4 1
2011-11-11protein level
1 4 1
2011-08-23protein level
1 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P50616-1
14 0 0 38130.8772
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-723281,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-723281,EBI-743073 CNOT3  
  .regulation of stem cell maintenance
.gene silencing by RNA
.gene expression
  + 6 more...
.N/A .CCR4-NOT complex
.cytosol
.nucleus
.cytoplasmic mRNA processing body
3 EBI-723281,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
4 EBI-723281,EBI-2848203 CPEB4  
  .cellular response to amino acid stimulus
.negative regulation of neuron apoptotic process
.cellular response to glucose starvation
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.dendrite
.postsynaptic density
.endoplasmic reticulum
  + 2 more...
5 EBI-723281,EBI-8596191 CPEB3  
  .positive regulation of mRNA polyadenylation
.negative regulation of cytoplasmic translational elongation
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  + 10 more...
.poly(A) RNA binding
.mRNA 3'-UTR AU-rich region binding
.RNA stem-loop binding
  + 5 more...
.apical dendrite
.synapse
.neuron projection
  + 4 more...
6 EBI-723281,EBI-1046635 CNOT6L  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.mRNA destabilization
.gene silencing by RNA
  + 8 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.CCR4-NOT complex
.cytosol
.cytoplasm
.nucleus
7 EBI-723281,EBI-2105113 CNOT7  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
  + 17 more...
.metal ion binding
.signal transducer activity
.poly(A)-specific ribonuclease activity
  + 4 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites25
bladder33
bone marrow61
brain5
connective tissue13
embryonic tissue4
eye33
intestine60
kidney14
liver24
lung11
mammary gland39
mouth15
muscle9
ovary19
pancreas4
placenta3
prostate5
skin28
stomach52
Health State
TissuesTPM*
normal12
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma48
colorectal tumor35
esophageal tumor57
gastrointestinal tumor16
head and neck tumor7
leukemia21
liver tumor20
lung tumor9
non-neoplasia31
ovarian tumor26
primitive neuroectodermal tumor of the CNS7
Developmental Stage
TissuesTPM*
adult26
embryoid body14
blastocyst16
fetus19
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36
adrenal gland188.6
appendix21.1
bone marrow40.2
cerebral cortex18.4
colon48.1
duodenum46.9
esophagus72.3
gallbladder48
heart muscle32.5
kidney52.3
liver71.6
lung34.5
lymph node15.8
ovary56.9
pancreas91.8
placenta11.2
prostate74.1
salivary gland54.8
skin34.9
small intestine41.1
spleen16.8
stomach56.6
testis25.6
thyroid gland77.3
urinary bladder62.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605523, gene) Transducer of erbb2, 1; TOB1OMIM


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