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> Protein (NX_P50750)
Protein (NX_P50750)
Protein
Gene SymbolCDK9 to neXtProt (NX_P50750)
DescriptionCyclin-dependent kinase 9
Chromosome9
Location9q34.11 (130547958 ~ 130553066) to Ensembl
Sequene Features : Isoforms 2, Variants 29, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of histone H2B ubiquitination
.positive regulation of mRNA 3'-UTR binding
.negative regulation of mRNA polyadenylation
  + 18 more...
.transcription regulatory region DNA binding
.snRNA binding
.RNA polymerase II carboxy-terminal domain kinase activity
  + 5 more...
.intracellular membrane-bounded organelle
.PML body
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 29 20
2014-09-19protein level
2 21 20
2014-05-27protein level
2 21 25
2014-02-25protein level
2 19 25
2013-12-09protein level
2 16 26
2013-11-01protein level
2 16 24
2013-09-12protein level
2 16 24
2013-08-17protein level
2 16 24
2013-07-15protein level
2 11 18
2013-06-11protein level
2 11 18
2013-02-12protein level
2 3 32
2012-12-20protein level
2 4 32
2012-10-30protein level
2 4 32
2012-10-07protein level
2 4 19
2012-08-24protein level
2 4 19
2012-07-28protein level
2 4 19
2012-06-08protein level
2 13 19
2012-05-07protein level
2 12 19
2012-04-10protein level
2 12 19
2012-01-13protein level
2 12 19
2011-12-20protein level
2 12 19
2011-11-11protein level
2 12 21
2011-08-23protein level
2 6 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P50750-1
0 16 1 42750.0293
NX_P50750-2
3 16 1 53331.3363
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1383449,EBI-2479671 CCNT1  
  .negative regulation of mRNA polyadenylation
.cell division
.positive regulation of viral transcription
  + 11 more...
.transcription regulatory region DNA binding
.snRNA binding
.chromatin binding
.DNA binding
.positive transcription elongation factor complex b
.nucleoplasm
.nucleus
2 EBI-1383449,EBI-2832510 HEXIM1  
  .positive regulation of signal transduction by p53 class mediator
.negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 3 more...
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-1383449,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
4 EBI-1383449,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
5 EBI-1383449,EBI-306914 FKBP5  
  .chaperone-mediated protein folding
.protein folding
.protein peptidyl-prolyl isomerization
.heat shock protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.extracellular exosome
.membrane
.endoplasmic reticulum membrane
.nucleoplasm
6 EBI-1383449,EBI-968983 ATR  
  .regulation of cellular response to heat
.replicative senescence
.cellular response to gamma radiation
  + 15 more...
.protein dimerization activity
.MutSalpha complex binding
.MutLalpha complex binding
  + 4 more...
.PML body
.Golgi apparatus
.chromosome
  + 2 more...
7 EBI-1383449,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
8 EBI-1383449,EBI-2371923 LARP7  
  .RNA processing .poly(A) RNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.cytoplasm
  + 2 more...
9 EBI-1383449,EBI-8464037 JMJD6  
  .histone H4-R3 demethylation
.histone H3-R2 demethylation
.retina development in camera-type eye
  + 15 more...
.peptidyl-lysine 5-dioxygenase activity
.identical protein binding
.histone demethylase activity (H4-R3 specific)
  + 5 more...
.plasma membrane
.nucleolus
.nucleoplasm
.nucleus
10 EBI-1383449,EBI-1211456 DHX30  
  .RNA processing .poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
  + 2 more...
.mitochondrial nucleoid
.mitochondrion
.cytoplasm
.nucleus
11 EBI-1383449,EBI-747353 ATRIP  
  .DNA repair
.DNA replication
.DNA damage checkpoint
.K63-linked polyubiquitin binding .nucleoplasm
.nucleus
12 EBI-1383449,EBI-1369377 CLSPN  
  .mitotic DNA replication checkpoint
.activation of protein kinase activity
.G2 DNA damage checkpoint
  + 7 more...
.anaphase-promoting complex binding
.DNA binding
.nucleoplasm
13 EBI-1383449,EBI-7216962 NR2E3  
  .retina development in camera-type eye
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of rhodopsin gene expression
  + 10 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
.steroid hormone receptor activity
.transcription factor complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood24
bone41
bone marrow20
brain17
cervix123
embryonic tissue46
esophagus49
eye19
heart22
intestine73
kidney37
liver19
lung38
lymph node77
mammary gland46
muscle9
nerve128
ovary68
pancreas14
parathyroid48
pharynx73
placenta42
prostate31
skin52
stomach20
testis9
thymus62
thyroid171
uterus64
vascular19
Health State
TissuesTPM*
normal32
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor144
chondrosarcoma12
colorectal tumor88
esophageal tumor57
gastrointestinal tumor25
germ cell tumor53
glioma37
head and neck tumor52
kidney tumor14
leukemia10
liver tumor31
lung tumor29
lymphoma13
non-neoplasia10
ovarian tumor39
prostate cancer9
uterine tumor44
Developmental Stage
TissuesTPM*
adult45
embryoid body57
blastocyst65
fetus34
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue41.1
adrenal gland52.2
appendix38
bone marrow50.7
cerebral cortex45.6
colon28
duodenum26.8
esophagus30.6
gallbladder39.7
heart muscle29
kidney30.8
liver29.4
lung52.9
lymph node53.3
ovary80.9
pancreas23.5
placenta34
prostate36.4
salivary gland24.6
skin30.2
small intestine26.1
spleen54.7
stomach31.5
testis42.4
thyroid gland33.6
urinary bladder33.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603251, gene) Cyclin-dependent kinase 9; CDK9OMIM


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