Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P51116)
Protein (NX_P51116)
Protein
Gene SymbolFXR2 to neXtProt (NX_P51116)
DescriptionFragile X mental retardation syndrome-related protein 2
Chromosome17
Location17p13.1 (7494548 ~ 7518189) to Ensembl
Sequene Features : Isoforms 1, Variants 52, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 52 10
2014-09-19protein level
1 41 10
2014-05-27protein level
1 41 12
2014-02-25protein level
1 40 11
2013-12-09protein level
1 30 11
2013-11-01protein level
1 29 11
2013-09-12protein level
1 29 11
2013-08-17protein level
1 29 11
2013-07-15protein level
1 21 10
2013-06-11protein level
1 21 10
2013-02-12protein level
1 8 10
2012-12-20protein level
1 8 10
2012-10-30protein level
1 9 10
2012-10-07protein level
1 9 10
2012-08-24protein level
1 5 10
2012-07-28protein level
1 5 10
2012-06-08protein level
1 6 10
2012-05-07protein level
1 6 10
2012-04-10protein level
1 6 10
2012-01-13protein level
1 5 10
2011-12-20protein level
1 5 10
2011-11-11protein level
1 5 10
2011-08-23protein level
1 5 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P51116-1
30 0 4 74177.7989
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740459,EBI-723574 ZBTB22  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-740459,EBI-7543896 SCEL  
  .keratinocyte differentiation
.embryo development
.epidermis development
.zinc ion binding .extracellular exosome
.cytoplasm
.cornified envelope
3 EBI-740459,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
4 EBI-740459,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
5 EBI-740459,EBI-696621 PIM1  
  .vitamin D receptor signaling pathway
.protein autophosphorylation
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 9 more...
.ribosomal small subunit binding
.manganese ion binding
.transcription factor binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
6 EBI-740459,EBI-712261 PAICS  
  .nucleobase-containing small molecule metabolic process
.small molecule metabolic process
.purine ribonucleoside monophosphate biosynthetic process
  + 3 more...
.identical protein binding
.ATP binding
.phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
.phosphoribosylaminoimidazole carboxylase activity
.extracellular exosome
.membrane
.cytosol
7 EBI-740459,EBI-742084 NT5C2  
  .nucleobase-containing small molecule metabolic process
.adenosine metabolic process
.IMP metabolic process
  + 6 more...
.nucleoside phosphotransferase activity
.metal ion binding
.5'-nucleotidase activity
.nucleotide binding
.cytosol
8 EBI-740459,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
9 EBI-740459,EBI-740475 PCBD1  
  .protein heterooligomerization
.protein homotetramerization
.positive regulation of transcription, DNA-templated
  + 6 more...
.identical protein binding
.4-alpha-hydroxytetrahydrobiopterin dehydratase activity
.phenylalanine 4-monooxygenase activity
.transcription coactivator activity
.extracellular exosome
.cytosol
.cytoplasm
.nucleoplasm
10 EBI-740459,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
11 EBI-740459,EBI-10224470 FMR1  
  .mRNA transport
.negative regulation of translational initiation
.negative regulation of translation
.central nervous system development
.poly(A) RNA binding
.mRNA binding
.RNA binding
.neuronal ribonucleoprotein granule
.synapse
.cell body
  + 11 more...
12 EBI-740459,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
13 EBI-740459,EBI-351018 CAMK2D  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of generation of L-type calcium current
.negative regulation of sodium ion transmembrane transport
  + 41 more...
.ion channel binding
.protein homodimerization activity
.titin binding
  + 5 more...
.perinuclear region of cytoplasm
.axon initial segment
.neuronal cell body
  + 12 more...
14 EBI-740459,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
15 EBI-740459,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
16 EBI-740459,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
17 EBI-740459,EBI-10244342 MIA3  
  .wound healing
.positive regulation of bone mineralization
.negative regulation of cell migration
  + 6 more...
.N/A .intracellular membrane-bounded organelle
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
18 EBI-740459,EBI-744052 C10orf62  
  .N/A .N/A .N/A
19 EBI-740459,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
20 EBI-740459,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
21 EBI-740459,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
22 EBI-740459,EBI-3919850 CDKL3  
  .dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
23 EBI-740459,EBI-2607770 PAF1  
  .cellular response to lipopolysaccharide
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of myeloid cell differentiation
  + 13 more...
.chromatin binding
.RNA polymerase II core binding
.Cdc73/Paf1 complex
.membrane
.cytoplasm
24 EBI-740459,EBI-1043145 MRPL43  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
25 EBI-740459,EBI-747142 SYTL4  
  .multivesicular body sorting pathway
.positive regulation of protein secretion
.calcium ion-dependent exocytosis of neurotransmitter
  + 6 more...
.neurexin family protein binding
.clathrin binding
.syntaxin binding
  + 4 more...
.exocytic vesicle
.transport vesicle membrane
.secretory granule
  + 6 more...
26 EBI-740459,EBI-739990 POM121  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.N/A .nuclear membrane
.endoplasmic reticulum membrane
.nuclear pore
.nuclear envelope
27 EBI-740459,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
28 EBI-740459,EBI-2860740 PRAM1  
  .regulation of neutrophil degranulation
.integrin-mediated signaling pathway
.lipid binding .N/A
29 EBI-740459,EBI-742459 MMTAG2  
  .N/A .poly(A) RNA binding .N/A
30 EBI-740459,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
31 EBI-740459,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
32 EBI-740459,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
33 EBI-740459,EBI-399266 MEAF6  
  .histone H3-K14 acetylation
.histone H4-K12 acetylation
.histone H4-K8 acetylation
  + 5 more...
.N/A .MOZ/MORF histone acetyltransferase complex
.NuA4 histone acetyltransferase complex
.centrosome
  + 3 more...
34 EBI-740459,EBI-741953 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
35 EBI-740459,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
36 EBI-740459,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
37 EBI-740459,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
38 EBI-740459,EBI-747632 LCMT1  
  .regulation of mitotic cell cycle spindle assembly checkpoint
.regulation of apoptotic process
.negative regulation of protein complex assembly
  + 4 more...
.S-adenosylmethionine-dependent methyltransferase activity
.protein C-terminal carboxyl O-methyltransferase activity
.cytosol
39 EBI-740459,EBI-10321972 BAZ2B  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites100
blood16
bone41
bone marrow20
brain23
cervix103
connective tissue20
embryonic tissue28
eye71
heart33
intestine64
kidney47
liver19
lung62
lymph112
lymph node100
mammary gland66
muscle37
nerve128
ovary59
pancreas42
placenta56
prostate15
salivary gland148
skin28
spleen18
stomach20
testis59
thymus37
uterus47
Health State
TissuesTPM*
normal32
adrenal tumor79
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma60
colorectal tumor8
gastrointestinal tumor101
germ cell tumor56
glioma74
head and neck tumor22
kidney tumor29
leukemia42
liver tumor31
lung tumor68
lymphoma110
non-neoplasia31
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma86
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult38
embryoid body71
blastocyst16
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland20.8
appendix12.2
bone marrow7.7
cerebral cortex21.5
colon13.2
duodenum13.9
esophagus17.4
gallbladder13.9
heart muscle39
kidney17.2
liver9.6
lung19
lymph node15.5
ovary14.8
pancreas7.9
placenta17.6
prostate17.6
salivary gland13.6
skin14.3
small intestine14
spleen16.9
stomach11.5
testis27.7
thyroid gland16.1
urinary bladder16.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605339, gene) Fragile x mental retardation, autosomal homolog 2; FXR2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center