Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P51451)
Protein (NX_P51451)
Protein
Gene SymbolBLK to neXtProt (NX_P51451)
DescriptionTyrosine-protein kinase Blk
Chromosome8
Location8p23.1 (11351510 ~ 11422113) to Ensembl
Sequene Features : Isoforms 1, Variants 99, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to peptide hormone stimulus
.B cell receptor signaling pathway
.innate immune response
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 99 2
2014-09-19protein level
1 77 2
2014-05-27protein level
1 77 3
2014-02-25protein level
1 75 3
2013-12-09protein level
1 58 3
2013-11-01protein level
1 51 3
2013-09-12protein level
1 51 3
2013-08-17protein level
1 51 3
2013-07-15protein level
1 40 3
2013-06-11protein level
1 40 3
2013-02-12protein level
1 26 2
2012-12-20protein level
1 26 2
2012-10-30protein level
1 25 2
2012-10-07protein level
1 25 2
2012-08-24protein level
1 21 2
2012-07-28protein level
1 21 2
2012-06-08protein level
1 23 2
2012-05-07protein level
1 19 2
2012-04-10protein level
1 19 2
2012-01-13protein level
1 10 2
2011-12-20protein level
1 10 2
2011-11-11protein level
1 10 2
2011-08-23protein level
1 10 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P51451-1
24 0 1 57669.4156
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2105445,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-2105445,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
3 EBI-2105445,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
4 EBI-2105445,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
5 EBI-2105445,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
bone marrow20
connective tissue20
intestine4
lung5
lymph451
lymph node133
mammary gland6
pancreas14
pharynx49
salivary gland148
spleen337
testis2
thymus87
thyroid42
tonsil352
Health State
TissuesTPM*
normal16
breast (mammary gland) tumor10
germ cell tumor15
leukemia158
lung tumor19
lymphoma318
non-neoplasia31
pancreatic tumor19
Developmental Stage
TissuesTPM*
adult5
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix19
bone marrow4.1
colon2.1
gallbladder1.7
liver1.1
lymph node56.4
salivary gland1.5
small intestine2
spleen35.1
stomach5.7
urinary bladder5.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191305, gene) Tyrosine kinase, b-lymphocyte specific; BLKOMIM
2(#613375, phenotype) Maturity-onset diabetes of the young, type 11; MODY11OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2020 (C) Yonsei Proteome Research Center