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> Protein (NX_P51610)
Protein (NX_P51610)
Protein
Gene SymbolHCFC1 to neXtProt (NX_P51610)
DescriptionHost cell factor 1
ChromosomeX
LocationXq28 (153213004 ~ 153237258) to Ensembl
Sequene Features : Isoforms 4, Variants 172, PTMs 38 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 172 38
2014-09-19protein level
4 119 38
2014-05-27protein level
4 119 38
2014-02-25protein level
4 117 35
2013-12-09protein level
4 99 35
2013-11-01protein level
4 98 33
2013-09-12protein level
4 98 33
2013-08-17protein level
4 98 33
2013-07-15protein level
3 52 24
2013-06-11protein level
3 52 24
2013-02-12protein level
3 12 61
2012-12-20protein level
3 10 61
2012-10-30protein level
3 15 61
2012-10-07protein level
3 15 27
2012-08-24protein level
3 9 27
2012-07-28protein level
3 9 27
2012-06-08protein level
3 60 27
2012-05-07protein level
3 60 27
2012-04-10protein level
3 60 27
2012-01-13protein level
3 61 27
2011-12-20protein level
3 61 27
2011-11-11protein level
3 61 25
2011-08-23protein level
3 61 25
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P51610-1
0 70 1 208601.5745
NX_P51610-2
1 67 1 201722.9403
NX_P51610-3
0 21 0 47158.9715
NX_P51610-4
4 69 1 213270.9847
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-396176,EBI-540779 SETD1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.stem cell maintenance
  + 3 more...
.histone methyltransferase activity (H3-K4 specific)
.RNA binding
.nucleotide binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nuclear speck
  + 3 more...
2 EBI-396176,EBI-539828 OGT  
  .regulation of gluconeogenesis involved in cellular glucose homeostasis
.histone H3-K4 trimethylation
.cellular response to retinoic acid
  + 21 more...
.protein O-GlcNAc transferase activity
.protein N-acetylglucosaminyltransferase activity
.acetylglucosaminyltransferase activity
  + 2 more...
.MLL5-L complex
.plasma membrane
.cytosol
  + 6 more...
3 EBI-396176,EBI-1644164 FOXO3  
  .regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
.extrinsic apoptotic signaling pathway in absence of ligand
  + 24 more...
.sequence-specific DNA binding
.chromatin DNA binding
.protein kinase binding
  + 5 more...
.membrane
.cytosol
.cytoplasm
  + 2 more...
4 EBI-396176,EBI-625002 CREB3  
  .negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
.negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.positive regulation of deacetylase activity
  + 19 more...
.protein dimerization activity
.protein homodimerization activity
.cAMP response element binding
  + 9 more...
.neuronal cell body
.integral component of endoplasmic reticulum membrane
.nuclear body
  + 9 more...
5 EBI-396176,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
6 EBI-396176,EBI-540834 WDR5  
  .histone H3-K4 methylation
.histone H4-K16 acetylation
.histone H4-K8 acetylation
  + 6 more...
.N/A .MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 4 more...
7 EBI-396176,EBI-638925 GABPA  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of megakaryocyte differentiation
.cell differentiation
  + 5 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.transcription coactivator activity
  + 6 more...
.nucleoplasm
.nucleus
.nuclear chromatin
8 EBI-396176,EBI-618165 GABPB1  
  .positive regulation of transcription from RNA polymerase II promoter
.mitochondrion organization
.organelle organization
  + 2 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
9 EBI-396176,EBI-372156 ZBTB17  
  .positive regulation of transcription, DNA-templated
.negative regulation of cell cycle
.cellular protein metabolic process
  + 5 more...
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleoplasm
10 EBI-396176,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
11 EBI-396176,EBI-1791447 BAP1  
  .positive regulation of protein targeting to mitochondrion
.protein K48-linked deubiquitination
.regulation of cell cycle
  + 7 more...
.peptidase activity
.ubiquitin-specific protease activity
.chromatin binding
.PR-DUB complex
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-396176,EBI-301821 HDAC2  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of protein deacetylation
.negative regulation of canonical Wnt signaling pathway
  + 44 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 14 more...
.protein complex
.ESC/E(Z) complex
.NuRD complex
  + 8 more...
13 EBI-396176,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
14 EBI-396176,EBI-1790529 THAP11  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.intercellular bridge
.cytoplasm
.nucleoplasm
15 EBI-396176,EBI-347218 SIN3A  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of histone H3-K27 acetylation
.negative regulation of protein localization to nucleus
  + 27 more...
.protein deacetylase activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.intercellular bridge
.transcriptional repressor complex
.Sin3 complex
  + 6 more...
16 EBI-396176,EBI-540496 SUDS3  
  .negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
.positive regulation of apoptotic process
  + 8 more...
.histone deacetylase binding
.enzyme binding
.Sin3-type complex
.Sin3 complex
.cytoplasm
  + 2 more...
17 EBI-396176,EBI-632965 CREBZF  
  .regulation of sequence-specific DNA binding transcription factor activity
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
18 EBI-396176,EBI-540797 ASH2L  
  .histone H3-K4 methylation
.positive regulation of transcription from RNA polymerase II promoter
.response to estrogen
  + 7 more...
.metal ion binding
.transcription regulatory region DNA binding
.DNA binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
bladder66
blood73
bone41
bone marrow20
brain22
cervix82
connective tissue13
ear62
embryonic tissue93
eye67
heart11
intestine81
kidney37
larynx42
liver14
lung53
lymph541
lymph node133
mammary gland125
mouth105
muscle37
ovary137
pancreas56
pituitary gland60
placenta24
prostate36
salivary gland49
skin42
stomach62
testis6
thymus50
thyroid64
uterus51
vascular19
Health State
TissuesTPM*
normal39
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor182
cervical tumor57
chondrosarcoma36
colorectal tumor88
gastrointestinal tumor84
germ cell tumor60
glioma111
head and neck tumor82
kidney tumor43
leukemia84
lung tumor68
lymphoma360
non-neoplasia20
ovarian tumor157
pancreatic tumor38
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma129
skin tumor31
soft tissue/muscle tissue tumor55
uterine tumor88
Developmental Stage
TissuesTPM*
adult63
embryoid body100
blastocyst97
fetus43
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.7
adrenal gland9.4
appendix14.1
bone marrow23.2
cerebral cortex10
colon9.9
duodenum9.8
esophagus8.6
gallbladder8.6
heart muscle6.8
kidney9.1
liver3.1
lung10.9
lymph node17.5
ovary11.3
pancreas4.9
placenta9
prostate11.2
salivary gland10.4
skin10.7
small intestine8.9
spleen16.2
stomach10.3
testis11.6
thyroid gland7.9
urinary bladder9.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300019, gene) Host cell factor c1; HCFC1OMIM
2(#309541, phenotype) Mental retardation, x-linked 3; MRX3OMIM


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