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> Protein (NX_P51668)
Protein (NX_P51668)
Protein
Gene SymbolUBE2D1 to neXtProt (NX_P51668)
DescriptionUbiquitin-conjugating enzyme E2 D1
Chromosome10
Location10q21.1 (60094735 ~ 60130513) to Ensembl
Sequene Features : Isoforms 1, Variants 10, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 10 0
2014-09-19protein level
1 7 0
2014-05-27protein level
1 7 1
2014-02-25protein level
1 7 1
2013-12-09protein level
1 6 1
2013-11-01protein level
1 5 1
2013-09-12protein level
1 5 1
2013-08-17protein level
1 5 1
2013-07-15protein level
1 5 0
2013-06-11protein level
1 5 0
2013-02-12protein level
1 2 0
2012-12-20protein level
1 2 0
2012-10-30protein level
1 2 0
2012-10-07protein level
1 2 0
2012-08-24protein level
1 1 0
2012-07-28protein level
1 1 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P51668-1
2 0 2 16591.2977
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743540,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
2 EBI-743540,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-743540,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
4 EBI-743540,EBI-2129175 RNF111  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of protein ubiquitination
  + 9 more...
.ubiquitin protein ligase activity
.SUMO polymer binding
.ligase activity
.zinc ion binding
.protein complex
.cytoplasm
.nucleolus
  + 2 more...
5 EBI-743540,EBI-2129250 ZNRF1  
  .protein K48-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.synaptic vesicle membrane
.cell junction
.membrane
  + 3 more...
6 EBI-743540,EBI-1058491 OTUB1  
  .negative regulation of double-strand break repair
.negative regulation of histone H2A K63-linked ubiquitination
.protein K48-linked deubiquitination
  + 3 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.NEDD8-specific protease activity
.ubiquitin-specific protease activity
.extracellular exosome
.cytoplasm
7 EBI-743540,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
8 EBI-743540,EBI-357322 RNF126  
  .cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 7 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.cytoplasm
.nucleus
9 EBI-743540,EBI-2341005 MKRN2  
  .protein ubiquitination .poly(A) RNA binding
.ligase activity
.zinc ion binding
.intracellular
10 EBI-743540,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
11 EBI-743540,EBI-2130308 RNF14  
  .regulation of androgen receptor signaling pathway
.positive regulation of transcription, DNA-templated
.response to estradiol
  + 6 more...
.androgen receptor binding
.ubiquitin-like protein transferase activity
.ligase activity
  + 2 more...
.cytoplasm
.nucleus
12 EBI-743540,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
13 EBI-743540,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
14 EBI-743540,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
15 EBI-743540,EBI-2129242 RNF115  
  .protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 2 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder66
blood65
bone55
bone marrow41
brain18
connective tissue120
embryonic tissue56
esophagus49
eye19
heart22
intestine17
kidney14
larynx42
liver24
lung35
lymph node11
mammary gland39
mouth15
muscle94
pancreas9
placenta52
prostate10
salivary gland49
skin23
spleen18
stomach20
testis16
thymus12
umbilical cord217
uterus34
Health State
TissuesTPM*
normal27
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor35
esophageal tumor57
gastrointestinal tumor16
germ cell tumor15
head and neck tumor14
kidney tumor14
leukemia52
liver tumor31
lymphoma13
non-neoplasia10
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor135
uterine tumor66
Developmental Stage
TissuesTPM*
adult35
embryoid body14
blastocyst81
neonate96
fetus21
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.1
adrenal gland20.4
appendix32.2
bone marrow42.3
cerebral cortex12.4
colon15.3
duodenum11
esophagus14.6
gallbladder14.1
heart muscle34.7
kidney9
liver6.7
lung11.8
lymph node19.3
ovary10.4
pancreas4.3
placenta11.6
prostate12.3
salivary gland5.4
skin6.3
small intestine11.8
spleen17.5
stomach9
testis6.1
thyroid gland9.5
urinary bladder23.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602961, gene) Ubiquitin-conjugating enzyme e2d 1; UBE2D1OMIM


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