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> Protein (NX_P51946)
Protein (NX_P51946)
Protein
Gene SymbolCCNH to neXtProt (NX_P51946)
DescriptionCyclin-H
Chromosome5
Location5q14.3 (86687311 ~ 86708836) to Ensembl
Sequene Features : Isoforms 1, Variants 47, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 47 6
2014-09-19protein level
1 43 6
2014-05-27protein level
1 43 6
2014-02-25protein level
1 43 6
2013-12-09protein level
1 34 6
2013-11-01protein level
1 33 6
2013-09-12protein level
1 33 6
2013-08-17protein level
1 33 6
2013-07-15protein level
1 19 5
2013-06-11protein level
1 19 5
2013-02-12protein level
1 12 6
2012-12-20protein level
1 12 6
2012-10-30protein level
1 13 6
2012-10-07protein level
1 13 6
2012-08-24protein level
1 8 6
2012-07-28protein level
1 8 6
2012-06-08protein level
1 10 6
2012-05-07protein level
1 10 6
2012-04-10protein level
1 10 6
2012-01-13protein level
1 9 6
2011-12-20protein level
1 9 6
2011-11-11protein level
1 9 6
2011-08-23protein level
1 9 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P51946-1
19 0 0 37619.0917
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741406,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-741406,EBI-741415 SSSCA1  
  .cell division
.mitotic nuclear division
.N/A .N/A
3 EBI-741406,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
4 EBI-741406,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
5 EBI-741406,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
6 EBI-741406,EBI-741533 CTBP2  
  .white fat cell differentiation
.positive regulation of retinoic acid receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.NAD binding
.oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
.transcription corepressor activity
  + 2 more...
.synapse
.cell junction
.transcriptional repressor complex
.nucleus
7 EBI-741406,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
8 EBI-741406,EBI-745426 PPFIA1  
  .negative regulation of establishment of protein localization to plasma membrane
.negative regulation of stress fiber assembly
.glutamate secretion
  + 4 more...
.signal transducer activity .presynaptic active zone
.focal adhesion
.cytosol
.cytoplasm
9 EBI-741406,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
10 EBI-741406,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
11 EBI-741406,EBI-2808089 CCDC170  
  .N/A .N/A .N/A
12 EBI-741406,EBI-715161 DUSP12  
  .peptidyl-tyrosine dephosphorylation
.positive regulation of glucokinase activity
.protein dephosphorylation
.cellular protein modification process
.zinc ion binding
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
.nucleus
13 EBI-741406,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites50
bladder100
blood49
bone195
bone marrow307
brain45
cervix41
connective tissue13
ear62
embryonic tissue37
esophagus49
eye47
intestine43
kidney66
liver38
lung83
lymph node22
mammary gland26
muscle56
nerve128
ovary9
pancreas65
pharynx98
pituitary gland181
placenta77
prostate31
salivary gland49
skin99
stomach52
testis167
thymus12
thyroid21
uterus12
vascular77
Health State
TissuesTPM*
normal57
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma72
colorectal tumor17
esophageal tumor57
gastrointestinal tumor59
germ cell tumor37
glioma18
leukemia95
liver tumor10
lung tumor19
non-neoplasia31
ovarian tumor13
pancreatic tumor57
primitive neuroectodermal tumor of the CNS23
prostate cancer19
retinoblastoma21
skin tumor151
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult40
embryoid body28
blastocyst48
fetus46
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue37.3
adrenal gland42.6
appendix30.6
bone marrow52.8
cerebral cortex28.6
colon23.1
duodenum19.2
esophagus18.7
gallbladder34.7
heart muscle18.9
kidney27.8
liver27.8
lung20.5
lymph node33.9
ovary17
pancreas13
placenta22
prostate32.9
salivary gland19.8
skin16.4
small intestine21.8
spleen23.6
stomach22
testis65.6
thyroid gland32.9
urinary bladder27.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601953, gene) Cyclin h; CCNHOMIM


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