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	> Protein (NX_P51946) Protein (NX_P51946) Protein Gene Symbol CCNH to neXtProt (NX_P51946) Description Cyclin-H Chromosome 5 Location 5q14.3 (86687311 ~ 86708836) to Ensembl Sequene Features : Isoforms 1, Variants 47, PTMs 6 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .positive regulation of viral transcription .positive regulation of transcription from RNA polymerase II promoter .negative regulation of gene expression, epigenetic   + 20 more... .cyclin-dependent protein serine/threonine kinase regulator activity .kinase activity .TFIIK complex .cyclin-dependent protein kinase activating kinase holoenzyme complex .holo TFIIH complex   + 2 more... Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 1 47 6 2014-09-19 protein level 1 43 6 2014-05-27 protein level 1 43 6 2014-02-25 protein level 1 43 6 2013-12-09 protein level 1 34 6 2013-11-01 protein level 1 33 6 2013-09-12 protein level 1 33 6 2013-08-17 protein level 1 33 6 2013-07-15 protein level 1 19 5 2013-06-11 protein level 1 19 5 2013-02-12 protein level 1 12 6 2012-12-20 protein level 1 12 6 2012-10-30 protein level 1 13 6 2012-10-07 protein level 1 13 6 2012-08-24 protein level 1 8 6 2012-07-28 protein level 1 8 6 2012-06-08 protein level 1 10 6 2012-05-07 protein level 1 10 6 2012-04-10 protein level 1 10 6 2012-01-13 protein level 1 9 6 2011-12-20 protein level 1 9 6 2011-11-11 protein level 1 9 6 2011-08-23 protein level 1 9 6 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_P51946-1 19 0 0 37619.0917 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-741406,EBI-715849 NDC80     .attachment of mitotic spindle microtubules to kinetochore .cell division .attachment of spindle microtubules to kinetochore   + 7 more... .identical protein binding .structural constituent of cytoskeleton .Ndc80 complex .membrane .cytosol   + 5 more... 2 EBI-741406,EBI-741415 SSSCA1     .cell division .mitotic nuclear division .N/A .N/A 3 EBI-741406,EBI-375096 CDK2     .cellular response to nitric oxide .regulation of gene silencing .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle   + 20 more... .metal ion binding .cyclin binding .ATP binding .cyclin-dependent protein serine/threonine kinase activity .Cajal body .cytosol .centrosome   + 10 more... 4 EBI-741406,EBI-359352 PSMA1     .positive regulation of canonical Wnt signaling pathway .negative regulation of canonical Wnt signaling pathway .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle   + 23 more... .threonine-type endopeptidase activity .endopeptidase activity .RNA binding .extracellular exosome .proteasome core complex, alpha-subunit complex .polysome   + 7 more... 5 EBI-741406,EBI-476295 SFN     .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway .intrinsic apoptotic signaling pathway .negative regulation of protein serine/threonine kinase activity   + 20 more... .protein kinase C inhibitor activity .extracellular exosome .cytoplasmic vesicle membrane .cytosol   + 3 more... 6 EBI-741406,EBI-741533 CTBP2     .white fat cell differentiation .positive regulation of retinoic acid receptor signaling pathway .positive regulation of transcription from RNA polymerase II promoter   + 5 more... .NAD binding .oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor .transcription corepressor activity   + 2 more... .synapse .cell junction .transcriptional repressor complex .nucleus 7 EBI-741406,EBI-618309 GOLGA2     .negative regulation of protein binding .mitotic cell cycle .syntaxin binding .protein kinase binding .Golgi cisterna membrane .ER to Golgi transport vesicle .cis-Golgi network   + 4 more... 8 EBI-741406,EBI-745426 PPFIA1     .negative regulation of establishment of protein localization to plasma membrane .negative regulation of stress fiber assembly .glutamate secretion   + 4 more... .signal transducer activity .presynaptic active zone .focal adhesion .cytosol .cytoplasm 9 EBI-741406,EBI-739580 CALCOCO2     .response to interferon-gamma .viral process .protein homodimerization activity .perinuclear region of cytoplasm .intracellular membrane-bounded organelle .membrane   + 4 more... 10 EBI-741406,EBI-1643885 KLC3     .axon cargo transport .microtubule motor activity .neuron projection .ciliary rootlet .motile cilium   + 3 more... 11 EBI-741406,EBI-2808089 CCDC170     .N/A .N/A .N/A 12 EBI-741406,EBI-715161 DUSP12     .peptidyl-tyrosine dephosphorylation .positive regulation of glucokinase activity .protein dephosphorylation .cellular protein modification process .zinc ion binding .protein tyrosine/serine/threonine phosphatase activity .protein tyrosine phosphatase activity .cytoplasm .nucleus 13 EBI-741406,EBI-2212028 SSX2IP     .regulation of cell motility .centrosome organization .cilium assembly   + 3 more... .N/A .protein complex .ciliary basal body .centriolar satellite   + 3 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adipose tissue 77 adrenal gland 91 ascites 50 bladder 100 blood 49 bone 195 bone marrow 307 brain 45 cervix 41 connective tissue 13 ear 62 embryonic tissue 37 esophagus 49 eye 47 intestine 43 kidney 66 liver 38 lung 83 lymph node 22 mammary gland 26 muscle 56 nerve 128 ovary 9 pancreas 65 pharynx 98 pituitary gland 181 placenta 77 prostate 31 salivary gland 49 skin 99 stomach 52 testis 167 thymus 12 thyroid 21 uterus 12 vascular 77 Health State Tissues TPM* normal 57 adrenal tumor 158 bladder carcinoma 113 breast (mammary gland) tumor 32 cervical tumor 57 chondrosarcoma 72 colorectal tumor 17 esophageal tumor 57 gastrointestinal tumor 59 germ cell tumor 37 glioma 18 leukemia 95 liver tumor 10 lung tumor 19 non-neoplasia 31 ovarian tumor 13 pancreatic tumor 57 primitive neuroectodermal tumor of the CNS 23 prostate cancer 19 retinoblastoma 21 skin tumor 151 soft tissue/muscle tissue tumor 31 uterine tumor 11 Developmental Stage Tissues TPM* adult 40 embryoid body 28 blastocyst 48 fetus 46 juvenile 89 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 37.3 adrenal gland 42.6 appendix 30.6 bone marrow 52.8 cerebral cortex 28.6 colon 23.1 duodenum 19.2 esophagus 18.7 gallbladder 34.7 heart muscle 18.9 kidney 27.8 liver 27.8 lung 20.5 lymph node 33.9 ovary 17 pancreas 13 placenta 22 prostate 32.9 salivary gland 19.8 skin 16.4 small intestine 21.8 spleen 23.6 stomach 22 testis 65.6 thyroid gland 32.9 urinary bladder 27.5 Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*601953, gene) Cyclin h; CCNH OMIM

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