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> Protein (NX_P51965)
Protein (NX_P51965)
Protein
Gene SymbolUBE2E1 to neXtProt (NX_P51965)
DescriptionUbiquitin-conjugating enzyme E2 E1
Chromosome3
Location3p24.2 (23847394 ~ 23932807) to Ensembl
Sequene Features : Isoforms 3, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.cytosol
.nucleoplasm
.nucleus
.ubiquitin ligase complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 15 3
2014-09-19protein level
3 12 3
2014-05-27protein level
3 12 5
2014-02-25protein level
3 12 5
2013-12-09protein level
3 11 5
2013-11-01protein level
3 11 5
2013-09-12protein level
3 11 5
2013-08-17protein level
3 11 5
2013-07-15protein level
2 6 4
2013-06-11protein level
2 6 4
2013-02-12protein level
1 2 6
2012-12-20protein level
1 2 6
2012-10-30protein level
1 2 6
2012-10-07protein level
1 2 6
2012-08-24protein level
1 2 6
2012-07-28protein level
1 2 6
2012-06-08protein level
1 2 6
2012-05-07protein level
1 1 6
2012-04-10protein level
1 1 6
2012-01-13protein level
1 2 6
2011-12-20protein level
1 2 6
2011-11-11protein level
1 2 5
2011-08-23protein level
1 2 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P51965-1
0 3 4 21390.6044
NX_P51965-2
0 2 4 17988.1296
NX_P51965-3
0 2 4 19486.6273
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348546,EBI-2372238 RNF20  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.positive regulation of transcription, DNA-templated
  + 7 more...
.histone binding
.ubiquitin protein ligase binding
.ligase activity
  + 6 more...
.HULC complex
.nucleolus
.nucleoplasm
  + 2 more...
2 EBI-348546,EBI-2607770 PAF1  
  .cellular response to lipopolysaccharide
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of myeloid cell differentiation
  + 13 more...
.chromatin binding
.RNA polymerase II core binding
.Cdc73/Paf1 complex
.membrane
.cytoplasm
3 EBI-348546,EBI-2129250 ZNRF1  
  .protein K48-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.synaptic vesicle membrane
.cell junction
.membrane
  + 3 more...
4 EBI-348546,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood16
bone83
bone marrow61
brain38
cervix41
connective tissue40
ear186
embryonic tissue61
eye57
heart55
intestine60
kidney37
larynx42
liver58
lung47
lymph node66
mammary gland52
muscle75
nerve64
ovary59
pancreas37
parathyroid437
pharynx24
pituitary gland60
placenta77
prostate52
salivary gland98
skin90
spleen18
stomach52
testis22
thymus25
thyroid21
umbilical cord290
uterus86
vascular19
Health State
TissuesTPM*
normal49
adrenal tumor158
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma48
colorectal tumor35
gastrointestinal tumor50
germ cell tumor26
glioma37
head and neck tumor14
kidney tumor14
leukemia52
liver tumor72
non-neoplasia41
ovarian tumor78
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer86
retinoblastoma64
skin tumor71
soft tissue/muscle tissue tumor23
uterine tumor66
Developmental Stage
TissuesTPM*
adult58
embryoid body85
blastocyst81
neonate128
fetus41
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue57.5
adrenal gland53.4
appendix64.3
bone marrow75.6
cerebral cortex76.9
colon69.4
duodenum43.6
esophagus160.5
gallbladder128.5
heart muscle83.1
kidney50.7
liver41.4
lung82
lymph node146.6
ovary92.5
pancreas26.2
placenta81
prostate65.5
salivary gland47.9
skin84.8
small intestine46.4
spleen60.1
stomach53.3
testis61.2
thyroid gland119.1
urinary bladder157.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602916, gene) Ubiquitin-conjugating enzyme e2e 1; UBE2E1OMIM


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