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> Protein (NX_P52306)
Protein (NX_P52306)
Protein
Gene SymbolRAP1GDS1 to neXtProt (NX_P52306)
DescriptionRap1 GTPase-GDP dissociation stimulator 1
Chromosome4
Location4q23 (99182535 ~ 99365012) to Ensembl
Sequene Features : Isoforms 6, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mitochondrial calcium ion concentration
.positive regulation of GTPase activity
.negative regulation of endoplasmic reticulum calcium ion concentration
  + 2 more...
.GTPase activator activity .extracellular exosome
.cytosol
.endoplasmic reticulum
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 76 6
2014-09-19protein level
6 64 6
2014-05-27protein level
6 64 6
2014-02-25protein level
6 63 6
2013-12-09protein level
6 49 6
2013-11-01protein level
6 49 5
2013-09-12protein level
6 49 5
2013-08-17protein level
6 49 5
2013-07-15protein level
4 30 1
2013-06-11protein level
4 30 1
2013-02-12protein level
3 7 6
2012-12-20protein level
3 9 6
2012-10-30protein level
3 9 6
2012-10-07protein level
3 9 2
2012-08-24protein level
3 9 2
2012-07-28protein level
3 9 2
2012-06-08protein level
3 12 2
2012-05-07protein level
3 8 2
2012-04-10protein level
2 8 2
2012-01-13protein level
2 13 2
2011-12-20protein level
2 13 2
2011-11-11protein level
2 13 2
2011-08-23protein level
2 13 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P52306-1
0 30 0 66274.3374
NX_P52306-2
0 27 0 60997.8522
NX_P52306-3
0 27 0 61068.8891
NX_P52306-4
1 29 0 66274.3374
NX_P52306-5
0 30 0 66345.3743
NX_P52306-6
1 25 0 56499.5038
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746389,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
2 EBI-746389,EBI-6447271 PLEKHB1  
  .regulation of cell differentiation
.phototransduction
.multicellular organismal development
.signal transducer activity .integral component of membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder66
blood16
bone111
bone marrow61
brain145
cervix61
connective tissue154
ear124
embryonic tissue9
eye38
heart44
intestine64
kidney142
liver34
lung29
lymph node22
mammary gland33
mouth90
muscle56
ovary9
pancreas14
parathyroid582
pharynx24
pituitary gland181
placenta10
prostate21
skin94
spleen93
stomach62
testis34
thymus50
trachea135
uterus47
vascular96
Health State
TissuesTPM*
normal80
bladder carcinoma56
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma120
colorectal tumor62
gastrointestinal tumor75
germ cell tumor49
glioma65
head and neck tumor22
kidney tumor203
leukemia42
liver tumor52
lung tumor9
lymphoma55
non-neoplasia62
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS55
prostate cancer28
retinoblastoma43
skin tumor47
soft tissue/muscle tissue tumor167
uterine tumor22
Developmental Stage
TissuesTPM*
adult57
embryoid body14
blastocyst16
neonate193
fetus136
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.7
adrenal gland14.2
appendix19.8
bone marrow10.8
cerebral cortex56.8
colon19
duodenum10.6
esophagus24.1
gallbladder15.7
heart muscle8.9
kidney14.5
liver11
lung13.4
lymph node26.2
ovary11.7
pancreas11.7
placenta11.7
prostate11.3
salivary gland9.4
skin13
small intestine12.9
spleen18.8
stomach13.5
testis22.3
thyroid gland22.7
urinary bladder24
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*179502, gene) Rap1, gtpase-gdp dissociation stimulator 1; RAP1GDS1OMIM
2T-cell acute lymphoblastic leukemiaCGP


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