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> Protein (NX_P52597)
Protein (NX_P52597)
Protein
Gene SymbolHNRNPF to neXtProt (NX_P52597)
DescriptionHeterogeneous nuclear ribonucleoprotein F
Chromosome10
Location10q11.21 (43881065 ~ 43904614) to Ensembl
Sequene Features : Isoforms 1, Variants 58, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of RNA splicing
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 58 18
2014-09-19protein level
1 41 18
2014-05-27protein level
1 41 19
2014-02-25protein level
1 41 19
2013-12-09protein level
1 35 19
2013-11-01protein level
1 33 16
2013-09-12protein level
1 33 16
2013-08-17protein level
1 33 16
2013-07-15protein level
1 22 11
2013-06-11protein level
1 22 11
2013-02-12protein level
1 5 12
2012-12-20protein level
1 5 12
2012-10-30protein level
1 7 12
2012-10-07protein level
1 7 12
2012-08-24protein level
1 6 12
2012-07-28protein level
1 6 12
2012-06-08protein level
1 18 12
2012-05-07protein level
1 18 12
2012-04-10protein level
1 18 12
2012-01-13protein level
1 15 12
2011-12-20protein level
1 15 12
2011-11-11protein level
1 15 11
2011-08-23protein level
1 15 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P52597-1
15 0 2 45642.729
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352986,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-352986,EBI-486809 HNRNPM  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.alternative mRNA splicing, via spliceosome
.poly(A) RNA binding
.protein domain specific binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.extracellular exosome
.paraspeckles
  + 7 more...
3 EBI-352986,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
4 EBI-352986,EBI-946029 C1orf94  
  .N/A .N/A .N/A
5 EBI-352986,EBI-948630 DZIP3  
  .protein polyubiquitination .poly(A) RNA binding
.polyubiquitin binding
.phosphatase binding
  + 4 more...
.cytoplasm
6 EBI-352986,EBI-357061 TFG  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.signal transduction
.signal transducer activity .extracellular exosome
.cytoplasm
7 EBI-352986,EBI-3957665 HSFY1  
  .transcription, DNA-templated .sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleus
8 EBI-352986,EBI-1018153 HNRNPUL1  
  .gene expression
.response to virus
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.enzyme binding
.RNA binding
.ribonucleoprotein complex
.nucleoplasm
.nucleus
9 EBI-352986,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
10 EBI-352986,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland212
ascites702
bladder1004
blood449
bone153
bone marrow20
brain204
cervix371
connective tissue234
ear62
embryonic tissue253
esophagus496
eye277
heart245
intestine500
kidney265
larynx383
liver272
lung289
lymph428
lymph node122
mammary gland231
mouth332
muscle65
nerve514
ovary167
pancreas201
parathyroid48
pharynx319
pituitary gland60
placenta286
prostate247
salivary gland1134
skin389
spleen692
stomach282
testis353
thymus1066
thyroid279
tonsil705
trachea521
umbilical cord217
uterus366
vascular755
Health State
TissuesTPM*
normal264
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor268
cervical tumor463
chondrosarcoma132
colorectal tumor577
esophageal tumor521
gastrointestinal tumor472
germ cell tumor452
glioma139
head and neck tumor291
kidney tumor261
leukemia391
liver tumor479
lung tumor301
lymphoma401
non-neoplasia206
ovarian tumor223
pancreatic tumor247
primitive neuroectodermal tumor of the CNS370
prostate cancer260
retinoblastoma559
skin tumor239
soft tissue/muscle tissue tumor183
uterine tumor332
Developmental Stage
TissuesTPM*
adult224
embryoid body257
blastocyst325
neonate1223
fetus179
infant467
juvenile953
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue80.3
adrenal gland64.8
appendix124.2
bone marrow105.4
cerebral cortex35.8
colon111.9
duodenum114.3
esophagus100.5
gallbladder94.9
heart muscle50.1
kidney78.8
liver92.5
lung91.2
lymph node166.7
ovary77.7
pancreas41
placenta104.4
prostate79
salivary gland56.4
skin88.3
small intestine114.3
spleen110.8
stomach108.1
testis95.1
thyroid gland71.6
urinary bladder139.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601037, gene) Heterogeneous nuclear ribonucleoprotein f; HNRNPFOMIM


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