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> Protein (NX_P52735)
Protein (NX_P52735)
Protein
Gene SymbolVAV2 to neXtProt (NX_P52735)
DescriptionGuanine nucleotide exchange factor VAV2
Chromosome9
Location9q34.2 (136627016 ~ 136857726) to Ensembl
Sequene Features : Isoforms 3, Variants 114, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.ephrin receptor signaling pathway
  + 17 more...
.metal ion binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 114 8
2014-09-19protein level
3 95 8
2014-05-27protein level
3 95 8
2014-02-25protein level
3 94 8
2013-12-09protein level
3 70 8
2013-11-01protein level
3 66 8
2013-09-12protein level
3 66 8
2013-08-17protein level
3 66 8
2013-07-15protein level
3 43 8
2013-06-11protein level
3 43 8
2013-02-12protein level
3 28 18
2012-12-20protein level
3 30 18
2012-10-30protein level
3 33 18
2012-10-07protein level
3 33 8
2012-08-24protein level
3 21 8
2012-07-28protein level
3 21 8
2012-06-08protein level
3 24 8
2012-05-07protein level
3 24 8
2012-04-10protein level
3 24 8
2012-01-13protein level
3 7 8
2011-12-20protein level
3 7 8
2011-11-11protein level
3 7 6
2011-08-23protein level
3 7 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P52735-1
2 38 0 101223.4711
NX_P52735-2
0 40 0 99991.8792
NX_P52735-3
0 39 0 96969.5274
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297549,EBI-712991 TOM1L1  
  .negative regulation of mitotic nuclear division
.ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.activation of protein kinase activity
  + 3 more...
.ubiquitin binding
.protein kinase activator activity
.clathrin binding
.protein kinase binding
.extracellular exosome
.endosome membrane
.cytosol
  + 4 more...
2 EBI-297549,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-297549,EBI-476041 NEK3  
  .cell division
.mitotic nuclear division
.protein phosphorylation
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.axon
.cytoplasm
.nucleus
4 EBI-297549,EBI-727062 SH3BP2  
  .positive regulation of signal transduction
.signal transduction
.SH3/SH2 adaptor activity .N/A
5 EBI-297549,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
6 EBI-297549,EBI-375446 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder33
blood8
bone41
brain16
cervix20
connective tissue6
ear62
embryonic tissue51
esophagus148
intestine43
kidney47
larynx42
liver19
lung11
lymph node155
mammary gland26
mouth15
nerve128
ovary59
pancreas28
prostate15
skin14
stomach10
testis25
thymus12
thyroid21
uterus30
Health State
TissuesTPM*
normal24
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma36
colorectal tumor44
esophageal tumor173
gastrointestinal tumor25
germ cell tumor53
head and neck tumor22
kidney tumor43
leukemia84
liver tumor31
lung tumor19
lymphoma13
non-neoplasia10
ovarian tumor78
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
prostate cancer19
skin tumor15
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult17
embryoid body57
blastocyst81
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.4
adrenal gland21.6
appendix10
bone marrow1.8
cerebral cortex5.8
colon10.2
duodenum17.5
esophagus5.5
gallbladder15.2
heart muscle4.9
kidney16.8
liver13.6
lung13.4
lymph node13.6
ovary4
pancreas15.5
placenta11.2
prostate8.2
salivary gland9.8
skin5
small intestine19
spleen11
stomach9.2
testis5.4
thyroid gland17.1
urinary bladder10.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600428, gene) Vav2 oncogene; VAV2OMIM


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