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> Protein (NX_P53350)
Protein (NX_P53350)
Protein
Gene SymbolPLK1 to neXtProt (NX_P53350)
DescriptionSerine/threonine-protein kinase PLK1
Chromosome16
Location16p12.2 (23688977 ~ 23701688) to Ensembl
Sequene Features : Isoforms 1, Variants 84, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 84 17
2014-09-19protein level
1 70 17
2014-05-27protein level
1 70 17
2014-02-25protein level
1 70 17
2013-12-09protein level
1 54 17
2013-11-01protein level
1 53 14
2013-09-12protein level
1 53 13
2013-08-17protein level
1 53 13
2013-07-15protein level
1 34 12
2013-06-11protein level
1 34 12
2013-02-12protein level
1 17 12
2012-12-20protein level
1 18 12
2012-10-30protein level
1 24 12
2012-10-07protein level
1 24 12
2012-08-24protein level
1 24 12
2012-07-28protein level
1 24 12
2012-06-08protein level
1 51 12
2012-05-07protein level
1 44 12
2012-04-10protein level
1 44 12
2012-01-13protein level
1 36 12
2011-12-20protein level
1 36 12
2011-11-11protein level
1 34 13
2011-08-23protein level
1 34 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P53350-1
29 0 0 68211.391
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-476768,EBI-852291 EVI5  
  .cell division
.positive regulation of GTPase activity
.retrograde transport, endosome to Golgi
  + 3 more...
.Rab GTPase binding
.GTPase activator activity
.intracellular membrane-bounded organelle
.cytosol
.spindle
  + 3 more...
2 EBI-476768,EBI-716327 OFD1  
  .negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
.epithelial cilium movement involved in determination of left/right asymmetry
.cilium morphogenesis
  + 5 more...
.gamma-tubulin binding
.alpha-tubulin binding
.ciliary basal body
.centriolar satellite
.membrane
  + 6 more...
3 EBI-476768,EBI-1180783 CHEK2  
  .replicative senescence
.mitotic spindle assembly
.signal transduction involved in intra-S DNA damage checkpoint
  + 18 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.PML body
.Golgi apparatus
.nucleoplasm
4 EBI-476768,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-476768,EBI-629985 HSPA1A  
  .N/A .N/A .N/A
6 EBI-476768,EBI-970310 EIF4B  
  .cellular protein metabolic process
.gene expression
.insulin receptor signaling pathway
  + 5 more...
.poly(A) RNA binding
.translation initiation factor activity
.RNA binding
.nucleotide binding
.eukaryotic translation initiation factor 4F complex
.cytosol
7 EBI-476768,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
8 EBI-476768,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
9 EBI-476768,EBI-494804 FADD  
  .positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 49 more...
.identical protein binding
.death effector domain binding
.tumor necrosis factor receptor superfamily binding
  + 2 more...
.ripoptosome
.membrane raft
.cell body
  + 4 more...
10 EBI-476768,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
11 EBI-476768,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
12 EBI-476768,EBI-1044009 NEK9  
  .cell division
.mitotic nuclear envelope disassembly
.mitotic nuclear division
  + 2 more...
.metal ion binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
13 EBI-476768,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
14 EBI-476768,EBI-1765160 BIRC6  
  .negative regulation of extrinsic apoptotic signaling pathway
.spongiotrophoblast layer development
.labyrinthine layer development
  + 10 more...
.ligase activity
.cysteine-type endopeptidase inhibitor activity
.ubiquitin-protein transferase activity
.midbody
.membrane
.microtubule organizing center
  + 3 more...
15 EBI-476768,EBI-2511327 GTSE1  
  .microtubule-based process
.DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
.N/A .membrane
.cytoplasmic microtubule
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites1004
bladder167
blood114
bone69
bone marrow123
brain77
cervix206
connective tissue80
embryonic tissue98
esophagus99
eye129
heart22
intestine129
kidney99
liver209
lung104
lymph451
lymph node55
mammary gland59
mouth30
muscle75
ovary137
pancreas89
parathyroid97
placenta45
prostate68
salivary gland148
skin204
spleen18
stomach104
testis225
thymus250
thyroid107
tonsil293
trachea19
umbilical cord72
uterus90
vascular77
Health State
TissuesTPM*
normal44
bladder carcinoma113
breast (mammary gland) tumor96
cervical tumor115
chondrosarcoma36
colorectal tumor142
esophageal tumor115
gastrointestinal tumor438
germ cell tumor189
glioma270
head and neck tumor67
kidney tumor232
leukemia179
liver tumor312
lung tumor253
lymphoma332
non-neoplasia62
ovarian tumor118
pancreatic tumor171
primitive neuroectodermal tumor of the CNS456
prostate cancer125
retinoblastoma430
skin tumor319
soft tissue/muscle tissue tumor215
uterine tumor22
Developmental Stage
TissuesTPM*
adult77
embryoid body85
blastocyst146
neonate64
fetus53
infant297
juvenile467
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.3
appendix13.6
bone marrow21.8
cerebral cortex1.8
colon11
duodenum8.9
esophagus6.8
gallbladder2.1
lung1.4
lymph node26.1
placenta7.7
prostate1.3
salivary gland1.1
skin5.9
small intestine8.7
spleen5.1
stomach10.8
testis25.6
urinary bladder5.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602098, gene) Polo-like kinase 1; PLK1OMIM


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