Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P53365)
Protein (NX_P53365)
Protein
Gene SymbolARFIP2 to neXtProt (NX_P53365)
DescriptionArfaptin-2
Chromosome11
Location11p15.4 (6496910 ~ 6502666) to Ensembl
Sequene Features : Isoforms 3, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 29 3
2014-09-19protein level
3 16 3
2014-05-27protein level
3 16 3
2014-02-25protein level
3 15 3
2013-12-09protein level
3 11 3
2013-11-01protein level
3 10 3
2013-09-12protein level
3 10 3
2013-08-17protein level
3 10 3
2013-07-15protein level
2 9 3
2013-06-11protein level
2 9 3
2013-02-12protein level
2 3 1
2012-12-20protein level
2 2 1
2012-10-30protein level
2 5 1
2012-10-07protein level
2 5 1
2012-08-24protein level
2 3 1
2012-07-28protein level
2 3 1
2012-06-08protein level
2 3 1
2012-05-07protein level
2 3 1
2012-04-10protein level
2 3 1
2012-01-13protein level
1 0 1
2011-12-20protein level
1 0 1
2011-11-11protein level
1 0 0
2011-08-23protein level
1 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P53365-1
3 12 0 37832.2507
NX_P53365-2
1 11 0 29025.9631
NX_P53365-3
1 12 0 33761.2944
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-638194,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-638194,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-638194,EBI-638181 ARF6  
  .hepatocyte apoptotic process
.establishment of epithelial cell polarity
.positive regulation of establishment of protein localization to plasma membrane
  + 19 more...
.thioesterase binding
.GTP binding
.GTPase activity
.extracellular exosome
.recycling endosome membrane
.cleavage furrow
  + 11 more...
4 EBI-638194,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
5 EBI-638194,EBI-712105 ITGB3BP  
  .apoptotic signaling pathway
.cell division
.neurotrophin TRK receptor signaling pathway
  + 10 more...
.protein C-terminus binding
.signal transducer activity
.membrane
.cytosol
.cytoplasm
  + 3 more...
6 EBI-638194,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
7 EBI-638194,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
8 EBI-638194,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
9 EBI-638194,EBI-944295 MAL2  
  .N/A .N/A .extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 3 more...
10 EBI-638194,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
11 EBI-638194,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
12 EBI-638194,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites125
bladder33
blood81
bone139
bone marrow20
brain108
cervix247
connective tissue60
embryonic tissue37
esophagus49
eye67
heart33
intestine120
kidney137
larynx42
liver77
lung74
lymph496
lymph node11
mammary gland125
mouth30
muscle47
nerve193
ovary108
pancreas112
parathyroid97
pharynx49
pituitary gland302
placenta141
prostate52
salivary gland148
skin56
spleen112
stomach20
testis112
thymus100
thyroid107
tonsil58
trachea231
uterus86
vascular58
Health State
TissuesTPM*
normal89
bladder carcinoma56
breast (mammary gland) tumor128
cervical tumor231
chondrosarcoma120
colorectal tumor88
esophageal tumor57
gastrointestinal tumor75
germ cell tumor102
glioma139
head and neck tumor59
kidney tumor130
leukemia31
liver tumor104
lung tumor126
lymphoma360
non-neoplasia124
ovarian tumor105
pancreatic tumor190
primitive neuroectodermal tumor of the CNS149
prostate cancer67
retinoblastoma43
skin tumor63
soft tissue/muscle tissue tumor39
uterine tumor77
Developmental Stage
TissuesTPM*
adult99
embryoid body28
blastocyst16
neonate64
fetus70
infant127
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.2
adrenal gland26.8
appendix24.5
bone marrow18.8
cerebral cortex26.2
colon38.4
duodenum38.4
esophagus28.3
gallbladder27
heart muscle13.4
kidney26.9
liver17.5
lung28.2
lymph node24.5
ovary30.3
pancreas28.7
placenta31.8
prostate51.7
salivary gland48
skin30.3
small intestine36
spleen23.6
stomach50.2
testis22.6
thyroid gland38.8
urinary bladder27.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
breastHigh
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
kidneyLow
lungLow
nasopharynxMedium
pancreasMedium
placentaMedium
prostateHigh
rectumMedium
salivary glandHigh
seminal vesicleMedium
skin 1Medium
skin 2Low
small intestineMedium
soft tissue 1Low
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601638, gene) Adp-ribosylation factor-interacting protein 2; ARFIP2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center