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> Protein (NX_P53778)
Protein (NX_P53778)
Protein
Gene SymbolMAPK12 to neXtProt (NX_P53778)
DescriptionMitogen-activated protein kinase 12
Chromosome22
Location22q13.33 (50683879 ~ 50700254) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of muscle cell differentiation
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 14 more...
.ATP binding
.MAP kinase activity
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.mitochondrion
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 2
2014-09-19protein level
2 33 2
2014-05-27protein level
1 33 2
2014-02-25protein level
1 33 2
2013-12-09protein level
1 21 2
2013-11-01protein level
1 21 2
2013-09-12protein level
1 21 2
2013-08-17protein level
1 21 2
2013-07-15protein level
1 16 2
2013-06-11protein level
1 16 2
2013-02-12protein level
1 13 4
2012-12-20protein level
1 12 4
2012-10-30protein level
1 15 4
2012-10-07protein level
1 15 4
2012-08-24protein level
1 15 4
2012-07-28protein level
1 15 4
2012-06-08protein level
1 28 4
2012-05-07protein level
1 28 4
2012-04-10protein level
1 28 4
2012-01-13protein level
1 19 4
2011-12-20protein level
1 19 4
2011-11-11protein level
1 19 4
2011-08-23protein level
1 19 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P53778-1
1 15 2 41913.3225
NX_P53778-2
0 15 2 40781.6958
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-602406,EBI-710431 PTPN4  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity .cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
2 EBI-602406,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
3 EBI-602406,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood220
bone41
brain44
cervix123
connective tissue6
embryonic tissue4
esophagus148
eye14
heart11
kidney23
liver4
lung5
mammary gland6
muscle122
nerve64
pancreas28
placenta24
prostate31
salivary gland98
skin4
spleen18
testis9
trachea19
uterus8
vascular38
Health State
TissuesTPM*
normal20
breast (mammary gland) tumor10
chondrosarcoma36
esophageal tumor173
gastrointestinal tumor8
germ cell tumor18
glioma46
head and neck tumor14
kidney tumor43
leukemia285
liver tumor10
lung tumor19
lymphoma152
pancreatic tumor57
primitive neuroectodermal tumor of the CNS251
prostate cancer48
uterine tumor11
Developmental Stage
TissuesTPM*
adult26
embryoid body14
fetus21
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.5
adrenal gland3.3
appendix5.1
bone marrow2.2
cerebral cortex13
colon2.6
duodenum4.2
esophagus7.1
gallbladder7.6
heart muscle10.2
kidney6.4
liver1.1
lung7.9
lymph node6
ovary6.1
pancreas1.2
placenta5.6
prostate12
salivary gland2.2
skin1.4
small intestine2.8
spleen4.8
stomach3.5
testis5.3
thyroid gland3.1
urinary bladder6.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602399, gene) Mitogen-activated protein kinase 12; MAPK12OMIM


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