Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P53779)
Protein (NX_P53779)
Protein
Gene SymbolMAPK10 to neXtProt (NX_P53779)
DescriptionMitogen-activated protein kinase 10
Chromosome4
Location4q21.3 (86936276 ~ 87515284) to Ensembl
Sequene Features : Isoforms 4, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.stress-activated MAPK cascade
.regulation of sequence-specific DNA binding transcription factor activity
.rhythmic process
  + 21 more...
.ATP binding
.MAP kinase kinase activity
.JUN kinase activity
.plasma membrane
.cytosol
.mitochondrion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 64 5
2014-09-19protein level
4 42 5
2014-05-27protein level
4 42 6
2014-02-25protein level
4 43 6
2013-12-09protein level
4 41 6
2013-11-01protein level
4 40 6
2013-09-12protein level
4 40 5
2013-08-17protein level
4 40 5
2013-07-15protein level
4 21 4
2013-06-11protein level
4 21 4
2013-02-12protein level
4 6 20
2012-12-20protein level
4 6 20
2012-10-30protein level
4 6 20
2012-10-07protein level
4 6 6
2012-08-24protein level
4 0 6
2012-07-28protein level
4 0 6
2012-06-08protein level
4 3 6
2012-05-07protein level
4 11 6
2012-04-10protein level
4 11 6
2012-01-13protein level
4 3 6
2011-12-20protein level
4 1 4
2011-11-11protein level
4 1 4
2011-08-23protein level
2 0 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P53779-1
0 13 12 52551.2596
NX_P53779-2
0 13 12 48522.5295
NX_P53779-3
0 10 12 48097.15
NX_P53779-4
1 7 10 31912.0599
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713543,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
2 EBI-713543,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
3 EBI-713543,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
bladder33
bone13
brain10
connective tissue46
embryonic tissue14
eye71
heart22
intestine12
kidney4
lung8
mammary gland6
mouth45
muscle18
nerve64
ovary9
pancreas46
pharynx24
prostate58
spleen93
stomach20
testis101
thymus12
trachea96
uterus107
Health State
TissuesTPM*
normal8
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma12
gastrointestinal tumor8
germ cell tumor68
glioma9
head and neck tumor22
kidney tumor130
non-neoplasia134
primitive neuroectodermal tumor of the CNS23
prostate cancer28
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult1
blastocyst16
fetus8
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.6
adrenal gland29.9
appendix5.9
cerebral cortex112.9
colon8.2
duodenum5.9
esophagus21.6
gallbladder41.2
heart muscle8.2
kidney32.7
liver2.8
lung12.8
lymph node1.7
ovary27.8
pancreas5.6
placenta2.4
prostate42.1
salivary gland2.8
skin1.6
small intestine8.5
spleen8.9
stomach6.7
testis38.3
thyroid gland45.6
urinary bladder51.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602897, gene) Mitogen-activated protein kinase 10; MAPK10OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center