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> Protein (NX_P54252)
Protein (NX_P54252)
Protein
Gene SymbolATXN3 to neXtProt (NX_P54252)
DescriptionAtaxin-3
Chromosome14
Location14q32.12 (92524896 ~ 92572965) to Ensembl
Sequene Features : Isoforms 5, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to misfolded protein
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
  + 14 more...
.Lys48-specific deubiquitinase activity
.Lys63-specific deubiquitinase activity
.ATPase binding
  + 4 more...
.nuclear inclusion body
.mitochondrial membrane
.nuclear matrix
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 46 6
2014-09-19protein level
5 34 6
2014-05-27protein level
5 34 6
2014-02-25protein level
5 34 6
2013-12-09protein level
5 28 6
2013-11-01protein level
5 27 5
2013-09-12protein level
5 27 5
2013-08-17protein level
5 27 5
2013-07-15protein level
3 19 2
2013-06-11protein level
3 19 2
2013-02-12protein level
3 12 6
2012-12-20protein level
3 11 6
2012-10-30protein level
3 13 6
2012-10-07protein level
3 13 2
2012-08-24protein level
3 12 2
2012-07-28protein level
3 12 2
2012-06-08protein level
3 17 2
2012-05-07protein level
3 17 2
2012-04-10protein level
3 17 2
2012-01-13protein level
3 12 2
2011-12-20protein level
3 12 2
2011-11-11protein level
3 12 2
2011-08-23protein level
3 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P54252-1
2 13 0 41754.379
NX_P54252-2
0 14 0 41224.019
NX_P54252-3
1 11 0 34984.1639
NX_P54252-4
1 13 0 39613.356
NX_P54252-5
0 7 0 20619.9522
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9684323,EBI-716346 PARK2  
  .negative regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.negative regulation of spontaneous neurotransmitter secretion
  + 78 more...
.F-box domain binding
.ubiquitin-specific protease binding
.cullin family protein binding
  + 21 more...
.Parkin-FBXW7-Cul1 ubiquitin ligase complex
.Lewy body
.perinuclear region of cytoplasm
  + 9 more...
2 EBI-946046,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-946046,EBI-712814 HAP1  
  .positive regulation of nonmotile primary cilium assembly
.regulation of organelle transport along microtubule
.negative regulation of beta-amyloid formation
  + 19 more...
.brain-derived neurotrophic factor binding
.ion channel binding
.axon
.cell junction
.inclusion body
  + 8 more...
4 EBI-946046,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
5 EBI-946068,EBI-355164 VCP  
  .positive regulation of Lys63-specific deubiquitinase activity
.positive regulation of protein K63-linked deubiquitination
.error-free translesion synthesis
  + 22 more...
.ubiquitin-specific protease binding
.poly(A) RNA binding
.ADP binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 10 more...
6 EBI-946046,EBI-946080 C16orf70  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood57
bone69
bone marrow20
brain19
embryonic tissue46
esophagus49
eye33
heart33
intestine17
kidney9
liver24
lung35
lymph node89
mammary gland19
muscle37
nerve64
ovary68
pancreas28
pharynx24
placenta42
prostate10
stomach31
testis20
trachea19
uterus47
Health State
TissuesTPM*
normal30
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor32
chondrosarcoma24
colorectal tumor26
esophageal tumor57
gastrointestinal tumor25
germ cell tumor45
glioma18
liver tumor10
non-neoplasia72
ovarian tumor52
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma43
soft tissue/muscle tissue tumor23
uterine tumor55
Developmental Stage
TissuesTPM*
adult31
embryoid body42
blastocyst48
fetus34
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.3
adrenal gland9
appendix11.4
bone marrow11.7
cerebral cortex8.3
colon11.6
duodenum6.4
esophagus14.2
gallbladder10.5
heart muscle6.5
kidney9.9
liver8.6
lung10.5
lymph node11.9
ovary9.4
pancreas3.9
placenta10.3
prostate11.8
salivary gland5.1
skin13.6
small intestine7
spleen9.9
stomach11.8
testis16
thyroid gland9.3
urinary bladder14.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#109150, phenotype) Machado-joseph disease; MJDOMIM
2(*607047, gene) Ataxin 3; ATXN3OMIM


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